Results 41 to 50 of about 9,831 (166)

Immunity to PRRSV: Double-edged sword

Veterinary Microbiology, 1997
The immune system is a double-edged sword for porcine reproductive and respiratory syndrome virus (PRRSV) infection. On one edge PRRSV has a predilection for immune cells and the disease manifestations can be linked directly to changes in the immune system.
Molitor, T.W., Bautista, E.M., Choi, C.S.   +2 more
openaire   +2 more sources

PRRSV Vaccine Strain-Induced Secretion of Extracellular ISG15 Stimulates Porcine Alveolar Macrophage Antiviral Response against PRRSV [PDF]

Viruses, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) has disrupted the global swine industry since the 1980s. PRRSV-host interactions are largely still unknown but may involve host ISG15 protein. In this study, we developed a monoclonal antibody (Mab-3D5E6) specific for swine ISG15 (sISG15) by immunizing mice with recombinant sISG15.
Hongbin Liu, Bingjun Shi, Zhigang Zhang, Bao Zhao, Guangming Zhao, Yijing Li, Yuchen Nan   +6 more
openaire   +3 more sources

Comparative evaluation of 4 commercial modified‐live porcine reproductive and respiratory syndrome virus (PRRSV) vaccines against heterologous dual Korean PRRSV‐1 and PRRSV‐2 challenge [PDF]

Veterinary Medicine and Science, 2020
Abstract Background Four commercial porcine reproductive and respiratory syndrome virus (PRRSV) modified‐live vaccines (MLV) was compared to protect growing pigs against dual challenge of PRRSV‐1 and PRRSV‐2.
Taehwan Oh, Su‐Jin Park, Hyejean Cho, Siyeon Yang, Hee Jin Ham, Chanhee Chae   +5 more
openaire   +2 more sources

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

The FEBS Journal, EarlyView.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt, Richard Strasser, Hong Zhu, Angelo Kaldis, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Porcine reproductive and respiratory syndrome (PRRS) developments: An in-depth review of recent findings

Open Veterinary Journal
The porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) belonging to the Arteriviridae family is the cause of PRRS disease. After being discovered for the first time in the United States in 1987, this illness quickly expanded to Canada ...
Rimayanti Rimayanti, Aswin Rafif Khairullah, Tita Damayanti Lestari, Tatik Hernawati, Sri Mulyati, Suzanita Utama, Ratna Damayanti, Ikechukwu Benjamin Moses, Sheila Marty Yanestria, Muhammad Khaliim Jati Kusala, Ricadonna Raissa, Ima Fauziah, Syahputra Wibowo, Agung Prasetyo, Mo Awwanah, Kartika Afrida Fauzia   +15 more
doaj   +1 more source

MOLECULAR AND PATHOLOGICAL STUDIES OF POST-WEANING MULTI-SYSTEMIC WASTING SYNDROME AMONG PIGLETS IN KERALA, INDIA [PDF]

Exploratory Animal and Medical Research, 2019
Post weaning multi systemic wasting syndrome (PMWS) is an economically important porcine viral associated diseases caused by porcine circovirus 2(PCV2) in weaned piglets worldwide. Recently, the presence of PCV2 was reported in pig population of Kerala.
R. Sairam, B. Dhanush Krishna, K. Krithiga, I. S. Sajitha, P. M. Priya, Chintu Ravishankar, Mammen J. Abraham   +6 more
doaj  

Vectored vaccines to protect against PRRSV

Virus Research, 2010
PRRSV is the causative agent of the most important infectious disease affecting swine herds worldwide, producing great economic losses. Commercially available vaccines are only partially effective in protection against PRRSV. Moreover, modified live vaccines may allow virus shedding, and could revert generating virulent phenotypes.
Cruz, Jazmina L. G., Zuniga, Sonia, Becares, Martina, Sola, Isabel, Ceriani, Juan E., Juanola, Sandra, Plana, Juan, Enjuanes, Luis   +7 more
openaire   +3 more sources

The structural biology of PRRSV

Virus Research, 2010
Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, positive-sense single-stranded RNA virus belonging to the Arteriviridae family. Arteriviruses and coronaviruses are grouped together in the order Nidovirales, based on similarities in genome organization and expression strategy.
openaire   +2 more sources

Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis

BioEssays, Volume 48, Issue 3, March 2026.
NLRP3, a cytosolic innate immune sensor, responds to diverse activators that perturb cellular homeostasis. These disturbances generate molecular scaffolds that, through binding partners such as nucleic acids, lipids, and proteins, recruit and concentrate NLRP3. Scaffold‐mediated NLRP3 clustering promotes NLRP3 inflammasome assembly.
Elvira Boršić‐Mlinarič, Iva Hafner‐Bratkovič   +1 more
wiley   +1 more source