Results 51 to 60 of about 10,101 (182)

Outbreak of Porcine Reproductive and Respiratory Syndrome Virus 1 in Taiwan

Viruses, 2020
Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses in the swine industry worldwide. The PRRS virus (PRRSV) can be divided into two species, PRRSV 1 (European) and PRRSV 2 (North American).
Wei-Hao Lin, Kraijak Kaewprom, Sheng-Yuan Wang, Chuen-Fu Lin, Cheng-Yao Yang, Ming-Tang Chiou, Chao-Nan Lin   +6 more
doaj   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization

Microbiology Spectrum, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV), a porcine arterivirus, causes severe financial losses to global swine industry. Despite much research, the molecular mechanisms of PRRSV infection remains to be fully elucidated. In the current
Lei Wang, Rui Li, Rui Geng, Longxiang Zhang, Xin-xin Chen, Songlin Qiao, Gaiping Zhang   +6 more
doaj   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

The 2b protein as a minor structural component of PRRSV [PDF]

Virus Research, 2005
Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2 contains an internal ORF that codes for a small non-glycosylated protein known as 2b. Previous work had identified the presence of a 10kDa 2b protein in virus-infected cells and the induction of an anti-2b response in PRRSV-infected pigs, as well as a possible association of 2b with the ...
Wu, Wai-Hong, Fang, Ying, Rowland, Raymond R.R., Lawson, Steven R., Christopher-Hennings, Jane, Yoon, Kyoung-Jin, Nelson, Eric A.   +6 more
openaire   +2 more sources

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets

Veterinary Research, 2021
Neutralizing antibodies (NAbs) have attracted attention as tools for achieving PRRSV control and prevention, but viral antigenic variation undermines the abilities of NAbs elicited by attenuated PRRSV vaccines to confer full protection against ...
Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou, Yuchen Nan, Chunyan Wu   +11 more
doaj   +1 more source

Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT Haematological parameters are important indicators of health, physiological status and resilience. In pigs, these parameters are influenced by both exogenous factors, such as feeding, housing and weaning age and intrinsic factors, including physiological maturity and genetic background.
Kanishka Kapoor, Michael Oster, Henry Reyer, Cornelia C. Metges, Eduard Muráni, Siriluck Ponsuksili, Klaus Wimmers   +6 more
wiley   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9’s Antiviral Effect via Nsp11 Endoribonuclease Activity

Viruses, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry worldwide. Our previous study had indicated that proprotein convertase subtilisin/kexin type 9 (PCSK9) was a responsive gene in ...
Yujiao Zhang, Fei Gao, Liwei Li, Kuan Zhao, Shan Jiang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Changlong Liu, Guangzhi Tong   +9 more
doaj   +1 more source

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

The FEBS Journal, Volume 293, Issue 7, Page 1891-1907, April 2026.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt, Richard Strasser, Hong Zhu, Angelo Kaldis, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source