Results 51 to 60 of about 15,921 (224)

PRRSV-induced apoptosis at the late stage of infection.

, 2016
(A) The release of cytochrome c in PRRSV-infected MARC-145 cells. PRRSV-infected MARC-145 cells were subjected to mitochondrial/cytosolic fractionation at 8 h, 12 h, 16 h, 24 h, 36 h and 48 h post-infection (pi).
Ning Zhang (23771), Lei Xu (78676), Lei Zhou (19808), Shuaizhen Yuan (2839628), Xinna Ge (573347), Hanchun Yang (67762), Xin Guo (123593)   +6 more
core   +1 more source

Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by two-dimensional fluorescence difference gel electrophoresis [PDF]

, 2010
Background Porcine reproductive and respiratory syndrome with PRRS virus (PRRSV) infection, which causes significant economic losses annually, is one of the most economically important diseases affecting swine industry worldwide.
Qin Limei, Peiqing Cong, Wang Xiaoying, Xiangchun Yu, Li Anning, Xiao Shuqi, Cong Peiqing, Jia Jianyu, Niu Yuna, Xiaohong Liu, Xiaoying Wang, Limei Qin, Yuna Niu, Shuqi Xiao, Yu Xiangchun, Mo Delin, Anning Li, Qiwei Wang, Jianyu Jia, Wang Qiwei, Chen Yaosheng, Liu Xiaohong, Yaosheng Chen, Delin Mo, Kongju Zhu, Zhu Kongju   +25 more
core   +1 more source

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source

Porcine reproductive and respiratory syndrome (PRRS) developments: An in-depth review of recent findings

Open Veterinary Journal
The porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) belonging to the Arteriviridae family is the cause of PRRS disease. After being discovered for the first time in the United States in 1987, this illness quickly expanded to Canada ...
Rimayanti Rimayanti, Aswin Rafif Khairullah, Tita Damayanti Lestari, Tatik Hernawati, Sri Mulyati, Suzanita Utama, Ratna Damayanti, Ikechukwu Benjamin Moses, Sheila Marty Yanestria, Muhammad Khaliim Jati Kusala, Ricadonna Raissa, Ima Fauziah, Syahputra Wibowo, Agung Prasetyo, Mo Awwanah, Kartika Afrida Fauzia   +15 more
doaj   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

High pathogenicity of a Chinese NADC34-like PRRSV on pigs

, 2022
NADC34-like porcine reproductive and respiratory syndrome virus (PRRSV) has been reported to be prevalent in China since 2018 and became one of the main epidemic strains in some areas of China.
Tian, K., Zhu, Z., Liu, P., Lee, Hu Suk, Li, Q., Yu, X., Li, Y., Li, X., Fan, Juan, Hu Suk Lee, Li, Xiangdong, Yuan, L., Fan, J., Tian, Kegong, Sun, Z., Yu, Xiuling, Liu, Panrao, Li, Yanhua, Li, Qun, Sun, Zhe, Yuan, Lili, Zhu, Zhenbang, Panrao Liu, Lili Yuan, Qun Li, Yanhua Li, Juan Fan, Zhe Sun, Xiuling Yu, Kegong Tian, Zhenbang Zhu, Xiangdong Li   +31 more
core   +2 more sources

A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets

Veterinary Research, 2021
Neutralizing antibodies (NAbs) have attracted attention as tools for achieving PRRSV control and prevention, but viral antigenic variation undermines the abilities of NAbs elicited by attenuated PRRSV vaccines to confer full protection against ...
Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou, Yuchen Nan, Chunyan Wu   +11 more
doaj   +1 more source

PRRSv-specific IFNγ response before and after challenge.

, 2019
Spot forming units of 1x106 porcine PBMCs stimulated with RPMI medium (circles) or PRRS virus (squares, MOI of 1.0) were determined before PRRS virus challenge (a) and 10 days after PRRS virus challenge (b) by IFNγ ELISpot. c) Comparison of PRRSv (MOI 1)
Christian Kraft (269160), Michael Gassel (7456340), Rimma Hennies (7456328), Poul Henning Rathkjen (7456337), Marcus Gereke (77888), Karla Dreckmann (7456331), Marta Noguera (7456334)   +6 more
core   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source