Results 61 to 70 of about 10,101 (182)

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Molecular epidemiology of PRRSV: A phylogenetic perspective

Virus Research, 2010
Since its first discovery two decades ago, porcine reproductive and respiratory syndrome virus (PRRSV) has been the subject of intensive research due to its huge impact on the worldwide swine industry. Thanks to the phylogenetic analyses, much has been learned concerning the genetic diversity and evolution history of the virus.
Faaberg, KS, Hui, RKH, Leung, FCC, Stadejek, T, Murtaugh, MP, Wennblom, T, Lam, TTY, Hon, CC, Shi, M   +8 more
openaire   +4 more sources

Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis

BioEssays, Volume 48, Issue 3, March 2026.
NLRP3, a cytosolic innate immune sensor, responds to diverse activators that perturb cellular homeostasis. These disturbances generate molecular scaffolds that, through binding partners such as nucleic acids, lipids, and proteins, recruit and concentrate NLRP3. Scaffold‐mediated NLRP3 clustering promotes NLRP3 inflammasome assembly.
Elvira Boršić‐Mlinarič, Iva Hafner‐Bratkovič   +1 more
wiley   +1 more source

Establishment of CD163-truncated gene-edited pigs and evaluation of their anti-PRRSV ability

Huanan Nongye Daxue xuebao
ObjectiveThis study aims to generate Large White pigs with a five-amino acid deletion (Δ525-529, AHFGE) in the SRCR5 domain of CD163 using CRISPR/Cas9 gene editing combined with somatic cell nuclear transfer, and evaluate their resistance to porcine ...
Jiayong TAN, Jian ZHANG, Xiaohui YANG, Haiwen ZHONG, Huaqiang YANG, Gengyuan CAI   +5 more
doaj   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source

Hypothalamic–Pituitary–Thyroid and Adrenal Axis Modulation in Response to Fetal Porcine Reproductive and Respiratory Virus Infection

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
This study investigates the impact of fetal porcine reproductive and respiratory virus (PRRSV) infection on the Hypothalamic–Pituitary‐Thyroid/Adrenal axes. We report that infection‐induced nonthyroidal illness syndrome is associated with multitissue dysregulation of key genes involved in the control of endocrine function, providing insights into ...
Alyssa A. Smith, Glenn Hamonic, Graham S. Plastow, John C. S. Harding, J. Alex Pasternak   +4 more
wiley   +1 more source

Impact of a killed PRRSV vaccine on sow longevity in a PRRSV infected swine herd

Journal of Applied Animal Research, 2012
In porcine reproductive and respiratory syndrome virus (PRRSV)-infected farms, there is an increase in the female culling rate, mainly due to reproductive problems and culling of young females. This has significant economic importance, as the low female culling rate is an important management factor.
openaire   +1 more source

The GP2a 91/97/98 amino acid substitutions play critical roles in determining PRRSV tropism and infectivity but do not affect immune responses

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) isolates share a restricted cellular tropism. Marc-145 cells derived from African green monkey are one of the few cell lines supporting PRRSV propagation in vitro and are commonly used for PRRS ...
Ming Qiu, Shuai Li, Shubin Li, Zhe Sun, Hong Lin, Shuai Yang, Meng Cui, Yuejia Qiu, Wenhao Qi, Xiuling Yu, Shaobin Shang, Kegong Tian, François Meurens, Jianzhong Zhu, Nanhua Chen   +14 more
doaj   +1 more source

Pathogenesis and Transmission of a Reassorted H1 Influenza A Virus Detected in North American Swine

Influenza and Other Respiratory Viruses, Volume 20, Issue 2, February 2026.
ABSTRACT Background The USDA influenza A virus in swine national surveillance plan identified an increase in the detection frequency of a group of swine 1A.1.1.3 hemagglutinin (HA) clade viruses. This change was associated with reassortment events that resulted in new neuraminidase (NA) gene pairings.
Débora B. Goulart, Carine K. Souza, Giovana C. Zanella, Celeste A. Snyder, Janice C. Zanella, Alexey Markin, Bailey Arruda, Tavis K. Anderson, Amy L. Baker   +8 more
wiley   +1 more source

Field Evaluation of a Novel Combined Vaccine Against Porcine Circovirus Types 2a/d, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis With an Emphasis on Growth Performance

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
A field trial on three commercial farms evaluated a combined vaccine targeting PCV2a/d, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Vaccinated pigs showed improved average daily weight gain, stronger immune responses against these pathogens, and significantly reduced viral and mycoplasmal loads and lesion severity, supporting its efficacy under
Jeongmin Suh, Sehyeong Ham, Hyejin Na, Ikjae Kang, Taehwan Oh, Youngkook You, Bumsoo Park, Chanhee Chae   +7 more
wiley   +1 more source