Results 61 to 70 of about 15,921 (224)

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9’s Antiviral Effect via Nsp11 Endoribonuclease Activity

Viruses, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry worldwide. Our previous study had indicated that proprotein convertase subtilisin/kexin type 9 (PCSK9) was a responsive gene in ...
Yujiao Zhang, Fei Gao, Liwei Li, Kuan Zhao, Shan Jiang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Changlong Liu, Guangzhi Tong   +9 more
doaj   +1 more source

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization

Microbiology Spectrum, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV), a porcine arterivirus, causes severe financial losses to global swine industry. Despite much research, the molecular mechanisms of PRRSV infection remains to be fully elucidated. In the current
Lei Wang, Rui Li, Rui Geng, Longxiang Zhang, Xin-xin Chen, Songlin Qiao, Gaiping Zhang   +6 more
doaj   +1 more source

Glycyrrhiza polysaccharides inhibits PRRSV replication

Virology Journal, 2023
Abstract Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the
Youbing Yang, Yongjian Liu, Ran Lou, Ying Lei, Gan Li, Zhiqian Xu, Xiangbin You   +6 more
openaire   +3 more sources

Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-Modified Live Vaccines Reduce Seminal Shedding of Type 1 PRRSV but not Type 2 PRRSV in Infected Boars

, 2017
The objective of this study was to compare the effects of two commercial type 1 porcine reproductive and respiratory syndrome virus (PRRSV)-modified live vaccines on type 1 and type 2 PRRSV shedding in the semen of experimentally infected boars.
Kang, I., Park, C., Jeong, J., Park, S. -J., Chae, C., Kim, T., Choi, K.   +6 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, Volume 13, Issue 57, 14 October 2026.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

EGCG Restricts PRRSV Proliferation by Disturbing Lipid Metabolism

Microbiology Spectrum, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV) infection leads to late-term reproductive failure and respiratory illness that affect the global swine industry.
Peng-Wei Yu, Peng-Fei Fu, Lei Zeng, Yan-Li Qi, Xiu-Qing Li, Qi Wang, Guo-Yu Yang, Hua-Wei Li, Jiang Wang, Bei-Bei Chu, Meng-Di Wang   +10 more
doaj   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

PRRSV-Vaccinated, Seronegative Sows and Maternally Derived Antibodies (I): Impact on PRRSV-1 Challenge Outcomes in Piglets

, 2023
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) remains an infectious agent with high importance in the swine industry. In this study, the influence of maternally derived antibodies (MDAs) on an experimental PRRSV-1 challenge is investigated.
Fiers, Jorian, Mostin, Laurent, Maes, Dominiek, Cay, Ann-Brigitte, Parys, Anna, Lin, Huixing, Zheng, Chunfu, Ann-Brigitte Cay, Anna Parys, Laurent Mostin, Jorian Fiers, L. Mostin, Tignon, Marylène, F. Jorian, Dominiek Maes, A. Parys, M. Laurent, D. Maes, A.B. Cay, M. Tignon, Marylène Tignon, J. Fiers   +21 more
core   +2 more sources

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

The GP2a 91/97/98 amino acid substitutions play critical roles in determining PRRSV tropism and infectivity but do not affect immune responses

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) isolates share a restricted cellular tropism. Marc-145 cells derived from African green monkey are one of the few cell lines supporting PRRSV propagation in vitro and are commonly used for PRRS ...
Ming Qiu, Shuai Li, Shubin Li, Zhe Sun, Hong Lin, Shuai Yang, Meng Cui, Yuejia Qiu, Wenhao Qi, Xiuling Yu, Shaobin Shang, Kegong Tian, François Meurens, Jianzhong Zhu, Nanhua Chen   +14 more
doaj   +1 more source