Results 71 to 80 of about 15,921 (224)

Evaluation of PRRSV vaccine efficacy following infection with PRRSV 1-7-4

Journal of Swine Health and Production, 2021
Our objective was to evaluate whether porcine reproductive and respiratory syndrome virus (PRRSV) vaccination improved mortality and morbidity following experimental infection with a PRRSV restriction fragment length polymorphism 1-7-4. Results indicated that mortality and morbidity were significantly lower for vaccinated pigs as compared to ...
Erin Little, Jenelle Dunkelberger, Dan Hanson, John Eggert, Michael Gonda, Michael MacNeil, Egert Knol, Scott Dee   +7 more
openaire   +1 more source

Diagnostic antibodies at an inflection point: From discovery platforms to design‐oriented engineering

VIEW, Volume 7, Issue 5, October 2026.
This study systematically organizes the evolution of diagnostic antibodies from discovery platforms to design‐oriented engineering and analyzes the strengths and limitations of each approach. Meanwhile, it provides a critical, literature‐driven synthesis of current challenges, proposing integrated strategies for assay‐aware and function‐driven antibody
Qitao Song, Lulai Xu, Weilin Wu, Fei Xie, Yantong Pan, Tiantian Yang, Xiaoxia Xu, Yanyin Lin, Lihua Zhang, Jiahui Zhou, Junyou Zhou, Linping Li, Zhanhui Wang, Weijing Yi, Jing Wang   +14 more
wiley   +1 more source

Role of CD163 in PRRSV infection

Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious agent that poses a significant economic threat to the global swine industry. Efficient viral entry relies on interactions with cellular receptors, with CD163-a cysteine-rich scavenger receptor found on porcine alveolar macrophages (PAMs)-playing a critical role ...
Raymond R.R. Rowland, Alberto Brandariz-Nuñez   +1 more
openaire   +2 more sources

Functional impairment of PRRSV-specific peripheral CD3(+)CD8(high) cells [PDF]

, 2009
The replication of porcine reproductive and respiratory syndrome virus (PRRSV) in lungs and lymphoid tissues of PRRSV-infected pigs is already strongly reduced before the appearance of neutralizing antibodies, indicating that other immune mechanisms are ...
Delputte, Peter L., Bruno Goddeeris, Hans J. Nauwynck, Peter L. Delputte, Costers, Sarah, Lefebvre, David J., Goddeeris, Bruno, David J. Lefebvre, Sarah Costers, Nauwynck, Hans J., Nauwynck, Hans, Delputte, Peter, Lefebvre, David   +12 more
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Outbreak of Porcine Reproductive and Respiratory Syndrome Virus 1 in Taiwan

Viruses, 2020
Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses in the swine industry worldwide. The PRRS virus (PRRSV) can be divided into two species, PRRSV 1 (European) and PRRSV 2 (North American).
Wei-Hao Lin, Kraijak Kaewprom, Sheng-Yuan Wang, Chuen-Fu Lin, Cheng-Yao Yang, Ming-Tang Chiou, Chao-Nan Lin   +6 more
doaj   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Development and Application of an RT-PCR to Differentiate the Prevalent NA-PRRSV Strains in China

, 2017
Background: PRRSV features with genetic diversity and high mutation which leads to the emergence of a multiple of circulating virus strains with different virulence.
Juan Wang, Yingying Li, Guobiao Ji, Xiaodong Xu, Xiangdong Li, Yanlin Li, Feifei Tan   +6 more
core   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

MiR-320 inhibits PRRSV replication by targeting PRRSV ORF6 and porcine CEBPB

Veterinary Research
Abstract Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease caused by Porcine reproductive and respiratory syndrome virus (PRRSV), results in huge economic losses to the world pig industry. MiRNAs have been reported to be involved in regulation of viral infection.
Gao, Xiaoxiao, You, Xiangbin, Wang, Guowei, Liu, Mengtian, Ye, Longlong, Meng, Yufeng, Luo, Gan, Xu, Dequan, Liu, Min   +8 more
openaire   +4 more sources