Results 91 to 100 of about 14,311 (225)

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Linear epitopes of PRRSV-1 envelope proteins ectodomains are not correlated with broad neutralization [PDF]

Background Neutralizing antibodies against PRRSV are capable of conferring protection against viral reinfection, but they tend to be strain specific and usually have poor cross-reactivity.
Simarro Fernández, María Isabel, Prieto Suárez, María Cinta, Frómeta, Raquel, Castro Arganda, José María, Martínez Lobo, Francisco Javier, Castillo Pérez, Jaime José   +5 more
core   +1 more source

Establishment of CD163-truncated gene-edited pigs and evaluation of their anti-PRRSV ability

Huanan Nongye Daxue xuebao
ObjectiveThis study aims to generate Large White pigs with a five-amino acid deletion (Δ525-529, AHFGE) in the SRCR5 domain of CD163 using CRISPR/Cas9 gene editing combined with somatic cell nuclear transfer, and evaluate their resistance to porcine ...
Jiayong TAN, Jian ZHANG, Xiaohui YANG, Haiwen ZHONG, Huaqiang YANG, Gengyuan CAI   +5 more
doaj   +1 more source

Weaning stress induced alterations to the hypothalamic‐pituitary‐thyroid and ‐adrenal axes in swine

Physiological Reports, Volume 14, Issue 12, June 2026.
Abstract Combined modulation of the hypothalamic–pituitary–thyroid (HPT) and hypothalamic–pituitary–adrenal (HPA) axes is known to play a critical role in maintaining physiological stability in response to stress. In this study, stress induced modulation of these axes was examined using 20 pigs/treatment either weaned (WN), weaned with feed/water ...
Isabel B. Walpole, Alyssa A. Smith, Kaylyn G. Rudy, Dayeon Jeon, J. Scott Radcliffe, J. Alex Pasternak   +5 more
wiley   +1 more source

Functional impairment of PRRSV-specific peripheral CD3(+)CD8(high) cells [PDF]

, 2009
The replication of porcine reproductive and respiratory syndrome virus (PRRSV) in lungs and lymphoid tissues of PRRSV-infected pigs is already strongly reduced before the appearance of neutralizing antibodies, indicating that other immune mechanisms are ...
Nauwynck, Hans, Delputte, Peter L., Bruno Goddeeris, Hans J. Nauwynck, Peter L. Delputte, Costers, Sarah, Delputte, Peter, Lefebvre, David J., Goddeeris, Bruno, David J. Lefebvre, Sarah Costers, Lefebvre, David, Nauwynck, Hans J.   +12 more
core   +2 more sources

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by two-dimensional fluorescence difference gel electrophoresis [PDF]

, 2010
Background Porcine reproductive and respiratory syndrome with PRRS virus (PRRSV) infection, which causes significant economic losses annually, is one of the most economically important diseases affecting swine industry worldwide.
Qin Limei, Peiqing Cong, Wang Xiaoying, Xiangchun Yu, Li Anning, Xiao Shuqi, Cong Peiqing, Jia Jianyu, Niu Yuna, Xiaohong Liu, Xiaoying Wang, Limei Qin, Yuna Niu, Shuqi Xiao, Yu Xiangchun, Mo Delin, Anning Li, Qiwei Wang, Jianyu Jia, Wang Qiwei, Chen Yaosheng, Liu Xiaohong, Yaosheng Chen, Delin Mo, Kongju Zhu, Zhu Kongju   +25 more
core   +1 more source

Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT Haematological parameters are important indicators of health, physiological status and resilience. In pigs, these parameters are influenced by both exogenous factors, such as feeding, housing and weaning age and intrinsic factors, including physiological maturity and genetic background.
Kanishka Kapoor, Michael Oster, Henry Reyer, Cornelia C. Metges, Eduard Muráni, Siriluck Ponsuksili, Klaus Wimmers   +6 more
wiley   +1 more source

Impact of a killed PRRSV vaccine on sow longevity in a PRRSV infected swine herd

Journal of Applied Animal Research, 2012
In porcine reproductive and respiratory syndrome virus (PRRSV)-infected farms, there is an increase in the female culling rate, mainly due to reproductive problems and culling of young females. This has significant economic importance, as the low female culling rate is an important management factor.
openaire   +1 more source