Results 91 to 100 of about 15,921 (224)

Identification of SNPs Associated With mRNA Expression Differences of the Complement Receptor Type 1‐Like Gene in Landrace Weaned Piglets

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
ABSTRACT Objective The aim of this study is to investigate the association between single nucleotide polymorphisms (SNPs) of porcine complement receptor 1‐like (CR1‐like) gene and its mRNA expression. Methods SNP identification, qRT‐PCR absolute quantification, linkage disequilibrium analysis and dual‐luciferase reporter assay were performed using 392 ...
Wei Yin, Jiachen Cheng, Qiongyu Li, Luyang Xu, Hongquan Li, Kuohai Fan, Zhenbiao Zhang, Na Sun, Panpan Sun, Huizhen Yang   +9 more
wiley   +1 more source

A spatiotemporal risk prediction framework for PRRSV based on multisource data integration

Huanan Nongye Daxue xuebao
ObjectiveTo propose and validate a spatiotemporal risk prediction framework for porcine reproductive and respiratory syndrome virus (PRRSV) by integrating epidemiological, environmental factors, and phylodynamic data, thereby addressing the limitations ...
Jiyu ZHANG, Yankuo SUN
doaj   +1 more source

The impact of respiratory disease on production in the pig industry in Great Britain [PDF]

This thesis presents research on the epidemiology of respiratory diseases in pig herds in GB and their impact on pig morbidity and mortality. The role of management, characteristics of the herd, presence of multiple pathogens and control and ...
Evans, Charlotte Marie
core  

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Establishment of Systems to Enable Isolation of Porcine Monoclonal Antibodies Broadly Neutralizing the Porcine Reproductive and Respiratory Syndrome Virus

Frontiers in Immunology, 2019
The rapid evolution of porcine reproductive and respiratory syndrome viruses (PRRSV) poses a major challenge to effective disease control since available vaccines show variable efficacy against divergent strains.
David Goldeck, Dana M. Perry, Dana M. Perry, Jack W. P. Hayes, Jack W. P. Hayes, Luke P. M. Johnson, Luke P. M. Johnson, Jordan E. Young, Parimal Roychoudhury, Parimal Roychoudhury, Elle L. McLuskey, Elle L. McLuskey, Katy Moffat, Arjen Q. Bakker, Mark J. Kwakkenbos, Jean-Pierre Frossard, Raymond R. R. Rowland, Michael P. Murtaugh, Simon P. Graham, Simon P. Graham   +19 more
doaj   +1 more source

Vectored vaccines to protect against PRRSV

Virus Research, 2010
PRRSV is the causative agent of the most important infectious disease affecting swine herds worldwide, producing great economic losses. Commercially available vaccines are only partially effective in protection against PRRSV. Moreover, modified live vaccines may allow virus shedding, and could revert generating virulent phenotypes.
Cruz, Jazmina L. G., Zuniga, Sonia, Becares, Martina, Sola, Isabel, Ceriani, Juan E., Juanola, Sandra, Plana, Juan, Enjuanes, Luis   +7 more
openaire   +5 more sources

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska, Dorota Sołtys‐Kalina, Audrey Y.‐H. Teh   +2 more
wiley   +1 more source

Tilmicosin inhibits the infections of currently prevalent porcine reproductive and respiratory syndrome viruses via the downregulation of CD163 expression

Virulence
Porcine reproductive and respiratory syndrome virus (PRRSV) has a disastrous impact on the global swine industry. Even though PRRS commercial vaccines can provide homologous protection, broadly effective anti-PRRSV strategies are still in urgent need ...
Ming Qiu, Xinshuai Li, Shuai Li, Shubin Li, Ningjun Xie, Zhe Sun, Hong Lin, Jianzhong Zhu, Kegong Tian, Nanhua Chen   +9 more
doaj   +1 more source

Dijagnostika i karakteristike simultane PRRSV-1 I PRRSV-2 infekcije [PDF]

, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV) was first discovered in Serbia in 2001. PRRSV belongs to the family Arteriviridae and is further classified into two genotypes, genotype PRRSV-1 and PRRSV-2. While PRRSV-1 mainly causes respiratory symptoms, PRRSV-2 leads to reproductive disorders.
Milićević, Vesna, Glišić, Dimitrije, Veljović, Ljubiša, Savić, Božidar, Kureljušić, Branislav   +4 more
openaire  

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

npj Vaccines
More efficacious vaccines are required to improve control of porcine reproductive and respiratory syndrome viruses (PRRSV). One strategy that has shown promise is the use of centralized antigens, generated from consensus sequence data. Here, we evaluated
Rory C. F. de Brito, Yashar Sadigh, Joseph Bowman, Stephanie Clive, Ben Jackson, Miriam Pedrera, Fraser Crofts, Matthieu Bernard, Fabian Z. X. Lean, Alejandro Núñez, Julian Seago, Jean-Pierre Frossard, Simon P. Graham   +12 more
doaj   +1 more source