Results 91 to 100 of about 15,307 (229)

The GP2a 91/97/98 amino acid substitutions play critical roles in determining PRRSV tropism and infectivity but do not affect immune responses

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) isolates share a restricted cellular tropism. Marc-145 cells derived from African green monkey are one of the few cell lines supporting PRRSV propagation in vitro and are commonly used for PRRS ...
Ming Qiu, Shuai Li, Shubin Li, Zhe Sun, Hong Lin, Shuai Yang, Meng Cui, Yuejia Qiu, Wenhao Qi, Xiuling Yu, Shaobin Shang, Kegong Tian, François Meurens, Jianzhong Zhu, Nanhua Chen   +14 more
doaj   +1 more source

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, Volume 5, Issue 3, June 2026.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source

Immunity to PRRSV: Double-edged sword

Veterinary Microbiology, 1997
The immune system is a double-edged sword for porcine reproductive and respiratory syndrome virus (PRRSV) infection. On one edge PRRSV has a predilection for immune cells and the disease manifestations can be linked directly to changes in the immune system.
Molitor, T.W., Bautista, E.M., Choi, C.S.   +2 more
openaire   +2 more sources

Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by two-dimensional fluorescence difference gel electrophoresis [PDF]

, 2010
Background Porcine reproductive and respiratory syndrome with PRRS virus (PRRSV) infection, which causes significant economic losses annually, is one of the most economically important diseases affecting swine industry worldwide.
Qin Limei, Peiqing Cong, Wang Xiaoying, Xiangchun Yu, Li Anning, Xiao Shuqi, Cong Peiqing, Jia Jianyu, Niu Yuna, Xiaohong Liu, Xiaoying Wang, Limei Qin, Yuna Niu, Shuqi Xiao, Yu Xiangchun, Mo Delin, Anning Li, Qiwei Wang, Jianyu Jia, Wang Qiwei, Chen Yaosheng, Liu Xiaohong, Yaosheng Chen, Delin Mo, Kongju Zhu, Zhu Kongju   +25 more
core   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Vectored vaccines to protect against PRRSV

Virus Research, 2010
PRRSV is the causative agent of the most important infectious disease affecting swine herds worldwide, producing great economic losses. Commercially available vaccines are only partially effective in protection against PRRSV. Moreover, modified live vaccines may allow virus shedding, and could revert generating virulent phenotypes.
Cruz, Jazmina L. G., Zuniga, Sonia, Becares, Martina, Sola, Isabel, Ceriani, Juan E., Juanola, Sandra, Plana, Juan, Enjuanes, Luis   +7 more
openaire   +5 more sources

Improved Vaccine against PRRSV: Current Progress and Future Perspective [PDF]

, 2017
Porcine reproductive and respiratory syndrome virus (PRRSV), one of the most economically significant pathogens worldwide, has caused numerous outbreaks during the past 30 years. PRRSV infection causes reproductive failure in sows and respiratory disease
En-Min Zhou, Guoqian Gu, Chunyan Wu, Yuchen Nan, Weiyao Sun, Yan-Jin Zhang   +5 more
core   +1 more source

Establishment of Systems to Enable Isolation of Porcine Monoclonal Antibodies Broadly Neutralizing the Porcine Reproductive and Respiratory Syndrome Virus

Frontiers in Immunology, 2019
The rapid evolution of porcine reproductive and respiratory syndrome viruses (PRRSV) poses a major challenge to effective disease control since available vaccines show variable efficacy against divergent strains.
David Goldeck, Dana M. Perry, Dana M. Perry, Jack W. P. Hayes, Jack W. P. Hayes, Luke P. M. Johnson, Luke P. M. Johnson, Jordan E. Young, Parimal Roychoudhury, Parimal Roychoudhury, Elle L. McLuskey, Elle L. McLuskey, Katy Moffat, Arjen Q. Bakker, Mark J. Kwakkenbos, Jean-Pierre Frossard, Raymond R. R. Rowland, Michael P. Murtaugh, Simon P. Graham, Simon P. Graham   +19 more
doaj   +1 more source

Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-Modified Live Vaccines Reduce Seminal Shedding of Type 1 PRRSV but not Type 2 PRRSV in Infected Boars

, 2017
The objective of this study was to compare the effects of two commercial type 1 porcine reproductive and respiratory syndrome virus (PRRSV)-modified live vaccines on type 1 and type 2 PRRSV shedding in the semen of experimentally infected boars.
Kang, I., Park, C., Jeong, J., Park, S. -J., Chae, C., Kim, T., Choi, K.   +6 more
core   +1 more source

PRRSV Non-Structural Proteins Orchestrate Porcine E3 Ubiquitin Ligase RNF122 to Promote PRRSV Proliferation

, 2022
Ubiquitination plays a major role in immune regulation after viral infection. An alternatively spliced porcine E3 ubiquitin ligase RNF122 promoted PRRSV infection and upregulated in PRRSV-infected PAM cells was identified.
Ruiqi Sun, Jinhai Huang, Yanyu Guo, Jun Han, Lei Zhang, Lilin Zhang, Ruiqiao Li, Jingxuan Shi, Xiaoyang Li, Zheng Tan   +9 more
core   +1 more source