Results 81 to 90 of about 15,307 (229)

Identification of SNPs Associated With mRNA Expression Differences of the Complement Receptor Type 1‐Like Gene in Landrace Weaned Piglets

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
ABSTRACT Objective The aim of this study is to investigate the association between single nucleotide polymorphisms (SNPs) of porcine complement receptor 1‐like (CR1‐like) gene and its mRNA expression. Methods SNP identification, qRT‐PCR absolute quantification, linkage disequilibrium analysis and dual‐luciferase reporter assay were performed using 392 ...
Wei Yin, Jiachen Cheng, Qiongyu Li, Luyang Xu, Hongquan Li, Kuohai Fan, Zhenbiao Zhang, Na Sun, Panpan Sun, Huizhen Yang   +9 more
wiley   +1 more source

Dijagnostika i karakteristike simultane PRRSV-1 I PRRSV-2 infekcije [PDF]

, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV) was first discovered in Serbia in 2001. PRRSV belongs to the family Arteriviridae and is further classified into two genotypes, genotype PRRSV-1 and PRRSV-2. While PRRSV-1 mainly causes respiratory symptoms, PRRSV-2 leads to reproductive disorders.
Milićević, Vesna, Glišić, Dimitrije, Veljović, Ljubiša, Savić, Božidar, Kureljušić, Branislav   +4 more
openaire  

Establishment of CD163-truncated gene-edited pigs and evaluation of their anti-PRRSV ability

Huanan Nongye Daxue xuebao
ObjectiveThis study aims to generate Large White pigs with a five-amino acid deletion (Δ525-529, AHFGE) in the SRCR5 domain of CD163 using CRISPR/Cas9 gene editing combined with somatic cell nuclear transfer, and evaluate their resistance to porcine ...
Jiayong TAN, Jian ZHANG, Xiaohui YANG, Haiwen ZHONG, Huaqiang YANG, Gengyuan CAI   +5 more
doaj   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

In vitro characterization of PRRSV isolates with different in vivo virulence using monocyte-derived macrophages [PDF]

, 2019
The recent emergence of highly pathogenic porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) strains has caused severe economic losses. The biological elements defining virulence and pathogenicity are still unclear.
Martelli, Paolo, Sautter, Carmen Alexandra Nadine, Stadejek, Tomasz, Borghetti, Paolo, Summerfield, Artur, Garcia Nicolas, Obdulio, Canelli, Elena, Ogno, Giulia, Sautter, Carmen A., García-Nicolás, Obdulio   +9 more
core   +2 more sources

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska, Dorota Sołtys‐Kalina, Audrey Y.‐H. Teh   +2 more
wiley   +1 more source

The impact of respiratory disease on production in the pig industry in Great Britain [PDF]

This thesis presents research on the epidemiology of respiratory diseases in pig herds in GB and their impact on pig morbidity and mortality. The role of management, characteristics of the herd, presence of multiple pathogens and control and ...
Evans, Charlotte Marie
core  

Functional impairment of PRRSV-specific peripheral CD3(+)CD8(high) cells [PDF]

, 2009
The replication of porcine reproductive and respiratory syndrome virus (PRRSV) in lungs and lymphoid tissues of PRRSV-infected pigs is already strongly reduced before the appearance of neutralizing antibodies, indicating that other immune mechanisms are ...
Nauwynck, Hans, Delputte, Peter L., Bruno Goddeeris, Hans J. Nauwynck, Peter L. Delputte, Costers, Sarah, Delputte, Peter, Lefebvre, David J., Goddeeris, Bruno, David J. Lefebvre, Sarah Costers, Lefebvre, David, Nauwynck, Hans J.   +12 more
core   +1 more source

A spatiotemporal risk prediction framework for PRRSV based on multisource data integration

Huanan Nongye Daxue xuebao
ObjectiveTo propose and validate a spatiotemporal risk prediction framework for porcine reproductive and respiratory syndrome virus (PRRSV) by integrating epidemiological, environmental factors, and phylodynamic data, thereby addressing the limitations ...
Jiyu ZHANG, Yankuo SUN
doaj   +1 more source

Discovery of Novel Viruses and Common Contaminants From Unmapped DNA and RNA in Pigs and Chickens Under Different Housing Conditions

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Unmapped sequencing reads in livestock often contain valuable information about pathogens but are typically discarded. We analyzed blood‐derived DNA and RNA from chickens and pigs kept under high‐ and low‐biosecurity conditions, focusing on unmapped reads.
Martijn F. L. Derks, Bert Dibbits, Richard P. M. A. Crooijmans, Kim Lensing   +3 more
wiley   +1 more source