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PSAT1 Suppression Drives a Targetable Serine Dependence in AML
BloodFrom antifolates to asparaginase to IDH inhibitors, targeting cancer metabolism has proven useful in heme malignancies. In solid tumors, a therapy with recent momentum is depriving cancer of serine. In vivo, this is done with a serine- and glycine-free (-SG) diet, which is tolerated by mice and can slow tumor ...
Ilias Sinanidis +11 more
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PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
Nature Chemical BiologyTumor cells adapt to the inflammatory tumor microenvironment (TME) and develop resistance to immunotherapy, with ferroptosis being a major form of tumor cell death. However, the mechanisms by which tumor cells coordinate TME stimuli and their unique metabolic traits to evade ferroptosis and develop resistance to immunotherapy remain unclear.
Peixiang Zheng +35 more
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Novel and recurrent PHGDH and PSAT1 mutations in Chinese patients with Neu-Laxova syndrome
European Journal of Dermatology, 2019Neu-Laxova syndrome (NLS) is a rare hereditary disorder featuring intrauterine growth retardation, remarkable oedema with skin restriction, limb contracture, ichthyosis, and craniofacial anomaly. NLS shares multiple overlapping characteristics with several other inheritable refractory diseases: for example, harlequin foetus and restrictive dermopathy ...
Cheng, Ni +6 more
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Targeting FOXM1/PSAT1 axis by Brusatol inhibits lung cancer malignant progression
Pathology - Research and PracticeBrusatol (BRU), an extract from Brucea javanica, has been found to inhibit cancer progression. However, the downstream targets of Brusatol and its underlying mechanisms in lung cancer still not fully elucidate and warrant further investigation. Here, we identified that Brusatol significantly downregulated the mRNA and protein levels of phosphoserine ...
Siyi, Ou +6 more
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Abstract 543: Prevalence and significance of PSAT1 expression in human cancer.
Cancer ResearchAbstract Phosphoserine aminotransferase 1 (PSAT1) is an enzyme involved in de novo biosynthesis of L-serine by catalyzing the conversion of 3-phosphohydroxy-pyruvate to 3-phosphoserine. This reaction simultaneously produces α-ketoglutarate, thereby directly linking serine biosynthesis to glutamine metabolism, the tricarboxylic acid ...
Fiete Gehrisch +24 more
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Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
Autophagy, 2020Edouard Nice, Yuelong Wang, Wei Gao
exaly
miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells
Genes and Genomics, 2022Wang Huiling, Zhang Chaojie, Yaqin Wu
exaly
PSAT1 regulates cyclin D1 degradation and sustains proliferation of non‐small cell lung cancer cells
International Journal of Cancer, 2015Yanbing Li, Yi Yang
exaly