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Circ_0015756 promotes ovarian cancer progression via the miR-145–5p/PSAT1 axis
Reproductive Biology, 2022Circular RNA (circRNA) have been shown to exert vital functions in the pathological progressions of ovarian cancer (OC). Herein, this study aimed to investigate the role and mechanisms of circ_0015756 in OC progression. Levels of circ_0015756, microRNA (miR)- 145-5p and phosphoserine aminotransferase 1 (PSAT1) were detected using quantitative real-time
Yibin Pan
exaly +3 more sources
PSAT1 gene as a biomarker for targeting triple negative breast cancer in presence of Rapamycin
Nucleosides, Nucleotides & Nucleic Acids, 2022The Triple-Negative Breast Cancers (TNBCs) poor survival outcomes are related to not responding to hormonal therapy or targeting HER2 protein. The aim of this study was to introduce a drug among the conventional chemotherapy drugs based on the transcripts of the TNBC patients.
Mehdi Roshanian Bakhsh +3 more
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PSAT1 Suppression Drives a Targetable Serine Dependence in AML
BloodFrom antifolates to asparaginase to IDH inhibitors, targeting cancer metabolism has proven useful in heme malignancies. In solid tumors, a therapy with recent momentum is depriving cancer of serine. In vivo, this is done with a serine- and glycine-free (-SG) diet, which is tolerated by mice and can slow tumor ...
Ilias Sinanidis +11 more
openaire +1 more source
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
Nature Chemical BiologyTumor cells adapt to the inflammatory tumor microenvironment (TME) and develop resistance to immunotherapy, with ferroptosis being a major form of tumor cell death. However, the mechanisms by which tumor cells coordinate TME stimuli and their unique metabolic traits to evade ferroptosis and develop resistance to immunotherapy remain unclear.
Peixiang Zheng +35 more
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Novel and recurrent PHGDH and PSAT1 mutations in Chinese patients with Neu-Laxova syndrome
European Journal of Dermatology, 2019Neu-Laxova syndrome (NLS) is a rare hereditary disorder featuring intrauterine growth retardation, remarkable oedema with skin restriction, limb contracture, ichthyosis, and craniofacial anomaly. NLS shares multiple overlapping characteristics with several other inheritable refractory diseases: for example, harlequin foetus and restrictive dermopathy ...
Cheng, Ni +6 more
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Targeting FOXM1/PSAT1 axis by Brusatol inhibits lung cancer malignant progression
Pathology - Research and PracticeBrusatol (BRU), an extract from Brucea javanica, has been found to inhibit cancer progression. However, the downstream targets of Brusatol and its underlying mechanisms in lung cancer still not fully elucidate and warrant further investigation. Here, we identified that Brusatol significantly downregulated the mRNA and protein levels of phosphoserine ...
Siyi, Ou +6 more
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Abstract 543: Prevalence and significance of PSAT1 expression in human cancer.
Cancer ResearchAbstract Phosphoserine aminotransferase 1 (PSAT1) is an enzyme involved in de novo biosynthesis of L-serine by catalyzing the conversion of 3-phosphohydroxy-pyruvate to 3-phosphoserine. This reaction simultaneously produces α-ketoglutarate, thereby directly linking serine biosynthesis to glutamine metabolism, the tricarboxylic acid ...
Fiete Gehrisch +24 more
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miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells
Genes and Genomics, 2022YaQin Wu, Chaojie Zhang
exaly
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
Autophagy, 2020Edouard C Nice, Yuelong Wang, Wei Gao
exaly