Results 131 to 140 of about 3,887 (161)

miR-424 Targets AKT3 and PSAT1 and Has a Tumor-Suppressive Role in Human Colorectal Cancer [Retraction]. [PDF]

Cancer Manag Res
europepmc   +1 more source

Construction of prognostic risk prediction model of endometrial carcinoma based on bioinformatics analysis. [PDF]

Medicine (Baltimore)
Zhang Y, Zhou G.
europepmc   +1 more source

Proteomics-based investigation of the protective effect and mechanism of Agari-5 in rats with myocardial infarction. [PDF]

World J Cardiol
Zhao YB, Bao ZH, Tu Y, Qiu X, Bao YL, Su M, Qi HJ, Wan Q.   +7 more
europepmc   +1 more source

The Crosstalk Between YAP/TAZ and Cancer Metabolism: From Mechanistic Insights to Drug Discovery. [PDF]

Int J Mol Sci
Gao Y, Chen M, Lin S, Huang M, Jin J.
europepmc   +1 more source

Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors [PDF]

Cell Reports, 2022
A major challenge of targeting metabolism for cancer therapy is pathway redundancy, in which multiple sources of critical nutrients can limit the effectiveness of some metabolism-targeted therapies.
Laura M Selfors, Vipin Rawat, Taru Muranen   +2 more
exaly   +2 more sources

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2021
Abstract Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM) are caused by aberrant mechanistic Target of Rapamycin Complex 1 (mTORC1) activation due to loss of either TSC1 or TSC2 . Cytokine profiling of TSC2-deficient LAM patient-
Wei Shi, John M Asara, Elizabeth P Henske   +2 more
exaly   +3 more sources

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation [PDF]

Cell Metabolism, 2016
Embryonic stem cells (ESCs) undergo coordinated epigenetic and metabolic changes to differentiate properly. However, the precise mechanisms by which these alterations are fine-tuned in the early stages of differentiation have not been identified. In this study, we demonstrate that phosphoserine aminotransferase 1 (Psat1), an Oct4/Sox2/Nanog (OSN ...
Xing Jin, Yoon Kyung Jeon, Hong-Duk Youn
exaly   +3 more sources

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Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis

Oncogene, 2020
An increasing number of enzymes involved in serine biosynthesis have been identified and correlated with malignant evolution in various types of cancer. Here we showed that the overexpression of phosphoserine aminotransferase 1 (PSAT1) is widely found in lung cancer tissues compared with nontumor tissues and predicts a poorer prognosis in patients with
Yung-Chieh Chan, Yu-Chan Chang, Hsiang-Hao Chuang, Yi-Chieh Yang, Yuan-Feng Lin, Ming-Shyan Huang, Michael Hsiao, Chih-Jen Yang, Kuo-Tai Hua   +8 more
openaire   +2 more sources

Pathogenic PSAT1 Variants and Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Ichthyosis

Pediatric Neurology, 2023
Biallelic pathogenic phosphoserine aminotransferase 1 (PSAT1) variants generally cause a severe phenotype predominantly involving the central nervous system. Here, for the first time, we report two patients harboring pathogenic PSAT1 variants only manifested as polyneuropathy and ichthyosis.Two patients from unrelated families presenting with ...
Zhiying Xie, Yanyu Lu
exaly   +3 more sources