Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis. [PDF]
EMBO RepArtes MH +16 more
europepmc +1 more source
RNA-Seq of Gingival Fibroblasts Grown on Collagen Membranes and Hyaluronic Acid. [PDF]
J Funct BiomaterPanahipour L, Huang X, Gruber R.
europepmc +1 more source
LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer. [PDF]
Mol CancerSamuels M +11 more
europepmc +1 more source
Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors [PDF]
Cell Reports, 2022 A major challenge of targeting metabolism for cancer therapy is pathway redundancy, in which multiple sources of critical nutrients can limit the effectiveness of some metabolism-targeted therapies.
Laura Selfors +2 more
exaly +2 more sources
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Abstract Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM) are caused by aberrant mechanistic Target of Rapamycin Complex 1 (mTORC1) activation due to loss of either TSC1 or TSC2 . Cytokine profiling of TSC2-deficient LAM patient-
Wei Shi, John Asara, Elizabeth Henske
exaly +3 more sources
Juvenile-onset PSAT1-related neuropathy: A milder phenotype of serine deficiency disorder
Frontiers in Genetics, 2022 Background: Primary serine deficiency disorders have a broad range of the phenotypic spectrum. As an inborn error of metabolism, individuals with severe phenotype may be easily recognized with Neu-Laxova syndrome. However, late-onset mild phenotypes may be underdiagnosed and will lead to disastrous consequences due to treatment delays.Materials and ...
Deng Jianwen +2 more
exaly +4 more sources
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Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis
Oncogene, 2020An increasing number of enzymes involved in serine biosynthesis have been identified and correlated with malignant evolution in various types of cancer. Here we showed that the overexpression of phosphoserine aminotransferase 1 (PSAT1) is widely found in lung cancer tissues compared with nontumor tissues and predicts a poorer prognosis in patients with
Yung-Chieh Chan +8 more
openaire +2 more sources
Pathogenic PSAT1 Variants and Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Ichthyosis
Pediatric Neurology, 2023Biallelic pathogenic phosphoserine aminotransferase 1 (PSAT1) variants generally cause a severe phenotype predominantly involving the central nervous system. Here, for the first time, we report two patients harboring pathogenic PSAT1 variants only manifested as polyneuropathy and ichthyosis.Two patients from unrelated families presenting with ...
Zhiying Xie, Yanyu Lu
exaly +3 more sources
Circ_0015756 promotes ovarian cancer progression via the miR-145–5p/PSAT1 axis
Reproductive Biology, 2022Circular RNA (circRNA) have been shown to exert vital functions in the pathological progressions of ovarian cancer (OC). Herein, this study aimed to investigate the role and mechanisms of circ_0015756 in OC progression. Levels of circ_0015756, microRNA (miR)- 145-5p and phosphoserine aminotransferase 1 (PSAT1) were detected using quantitative real-time
Yizhen, Pan +4 more
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PSAT1 gene as a biomarker for targeting triple negative breast cancer in presence of Rapamycin
Nucleosides, Nucleotides & Nucleic Acids, 2022The Triple-Negative Breast Cancers (TNBCs) poor survival outcomes are related to not responding to hormonal therapy or targeting HER2 protein. The aim of this study was to introduce a drug among the conventional chemotherapy drugs based on the transcripts of the TNBC patients.
Mehdi Roshanian Bakhsh +3 more
openaire +2 more sources