Results 171 to 180 of about 3,665 (185)

Targeting FOXM1/PSAT1 axis by Brusatol inhibits lung cancer malignant progression

Pathology - Research and Practice
Brusatol (BRU), an extract from Brucea javanica, has been found to inhibit cancer progression. However, the downstream targets of Brusatol and its underlying mechanisms in lung cancer still not fully elucidate and warrant further investigation. Here, we identified that Brusatol significantly downregulated the mRNA and protein levels of phosphoserine ...
Siyi, Ou, Xiaobo, Wang, Yulan, Sun, Yongfeng, Liang, Jing, Bai, Chuanchun, Han, Jing, Song   +6 more
openaire   +2 more sources

Novel and recurrent PHGDH and PSAT1 mutations in Chinese patients with Neu-Laxova syndrome

European Journal of Dermatology, 2019
Neu-Laxova syndrome (NLS) is a rare hereditary disorder featuring intrauterine growth retardation, remarkable oedema with skin restriction, limb contracture, ichthyosis, and craniofacial anomaly. NLS shares multiple overlapping characteristics with several other inheritable refractory diseases: for example, harlequin foetus and restrictive dermopathy ...
Cheng, Ni, Ru-Hong, Cheng, Jia, Zhang, Jian-Ying, Liang, Ru-Qu, Wei, Ming, Li, Zhi-Rong, Yao   +6 more
openaire   +2 more sources

Abstract 543: Prevalence and significance of PSAT1 expression in human cancer.

Cancer Research
Abstract Phosphoserine aminotransferase 1 (PSAT1) is an enzyme involved in de novo biosynthesis of L-serine by catalyzing the conversion of 3-phosphohydroxy-pyruvate to 3-phosphoserine. This reaction simultaneously produces α-ketoglutarate, thereby directly linking serine biosynthesis to glutamine metabolism, the tricarboxylic acid ...
Fiete Gehrisch, Hendrina Contreras, Maximilian Lennartz, Katharina Möller, Nathalia Gorbokon, Martina Kluth, Claudia Hube-Magg, Maria Christina Tsourlakis, Nina Schraps, Florian Viehweger, David Dum, Andrea Hinsch, Christoph Fraune, Christian Bernreuther, Patrick Lebok, Guido Sauter, Till S. Clauditz, Till Krech, Andreas H. Marx, Ronald Simon, Eike Burandt, Sarah Minner, Stefan Steurer, Ria Schlichter, Seyma Büyücek   +24 more
openaire   +1 more source

miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells

Genes and Genomics, 2022
Yaqin Wu, Wang Huiling, Zhang Chaojie
exaly  

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Autophagy, 2020
Lu Zhang, Yunlong Lei, Yuelong Wang
exaly  

Overexpression of PSAT1 Gene is a Favorable Prognostic Marker in Lower-Grade Gliomas and Predicts a Favorable Outcome in Patients with IDH1 Mutations and Chromosome 1p19q Codeletion

Cancers, 2020
Yung-Chieh Chan, Shang-Yu Huang, Yuan-Feng Lin   +2 more
exaly  

Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer

Clinical and Experimental Metastasis, 2019
Traci Kruer, Nazarul Hasan, Brian F Clem   +2 more
exaly  

Affinity war: PSAT1 outcompetes the rest

Nature Metabolism
openaire   +1 more source

PSAT1 regulates cyclin D1 degradation and sustains proliferation of non‐small cell lung cancer cells

International Journal of Cancer, 2015
Yi Yang, Jueheng Wu, Junchao Cai
exaly  

Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma

Experimental Cell Research
Huayi Feng, Xupeng Zhao, Shouqing Cao
exaly