Results 101 to 110 of about 14,191 (208)

DEVELOPMENT OF THE VACCINE BASED ON THE RECOMBINANT ANTIGENS OF PSEUDOMONAS AERUGINOSA

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Aim. The aim is obtaining, investigation and selection of recombinant antigens for inclusion theirs into the against Pseudomonas vaccine. Materials and methods. The genes encoding of the outer  membrane proteins F, L and I and Exotoxin A were synthesized
N. A. Mihailova, E. M. Zimina, A. V. Soldatenkova, A. A. Kaloshin   +3 more
doaj   +1 more source

Ferric uptake regulator Fur is conditionally essential in Pseudomonas aeruginosa [PDF]

, 2017
In Pseudomonas aeruginosa, the ferric uptake regulator (Fur) protein controls both metabolism and virulence in response to iron availability. Differently from other bacteria, attempts to obtain fur deletion mutants of P. aeruginosa failed, leading to the
Banin, Ehud, Genah, Shirley, Imperi, Francesco, Lo Sciuto, Alessandra, Pasqua, Martina, Visaggio, Daniela, Visca, Paolo   +6 more
core   +1 more source

Molecular Study of the Prevalence of Exotoxin A and Alginate Gene in Pseudomonas Aeruginosa Isolates in Burn Wounds Samples

مجله دانشکده پزشکی اصفهان, 2017
Background: Pseudomonas aeruginosa is one of the major nosocomial pathogens with a vast antibiotic resistance and great ability in adaptation with environment.
Seyed Hamidreza Mortazavi, Mehdi Ghaderi, Mitra Hemmati, Siavash Vaziri, Mohsen Azizi, Mahsa Kashef, Kamal Ahmadi   +6 more
doaj  

A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxin.

PLoS ONE, 2010
Diphtheria toxin (DT), Pseudomonas aeruginosa Exotoxin A (ETA) and cholix toxin from Vibrio cholerae share the same mechanism of toxicity; these enzymes ADP-rybosylate elongation factor-2 (EF-2) on a modified histidine residue called diphthamide, leading
Vincent Roy, Karim Ghani, Manuel Caruso
doaj   +1 more source

Novel Anti-Mesothelin Nanobodies and Recombinant Immunotoxins with Pseudomonas Exotoxin Catalytic Domain for Cancer Therapeutics. [PDF]

Mol Cells, 2023
Nguyen MQ, Kim DH, Shim HJ, Ta HKK, Vu TL, Nguyen TKO, Lim JC, Choe H.   +7 more
europepmc   +1 more source

Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey [PDF]

, 2014
Short linear motifs (SLiMs) are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein–protein interactions.
Ambarnil Ghosh, Catrióna R. Johnston, Daniel Hurley, Denis C. Shields, Heini Ruhanen, Kevin T. O'Brien   +5 more
core   +1 more source

Evaluating the influence of common antibiotics on the efficacy of a recombinant immunotoxin in tissue culture

BMC Research Notes, 2019
Objective Recombinant immunotoxins (RITs) are antibody-toxin fusion proteins that can selectively eliminate populations of cells expressing specific surface receptors. They are in evaluation as therapeutic agents for cancer.
Yuyi Zhu, John E. Weldon
doaj   +1 more source

Efficacy of Hormone-Toxin Fusion Protein in Cell Culture [PDF]

, 2015
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are members of the gonadotropin family and are vital for fertility in animals. Both LH and hCG bind to the luteinizing hormone receptor (LHR), found only in gonadal cells.
Dillard, Morgan
core   +1 more source

The Proteome of Biologically Active Membrane Vesicles from Piscirickettsia salmonis LF-89 Type Strain Identifies Plasmid-Encoded Putative Toxins [PDF]

, 2017
Indexación: Scopus.Piscirickettsia salmonis is the predominant bacterial pathogen affecting the Chilean salmonid industry. This bacterium is the etiological agent of piscirickettsiosis, a significant fish disease.
Artigues, A., Avendaño-Herrera, R., Cortés, M.A., Haro, R.E., Hernández, M.A., Lagos, L.X., Oliver, C., Ruiz, P.A., Sanhueza-Oyarzún, C., Sánchez, P., Tandberg, J.I., Valenzuela, K.N., Villar, M.T., Winther-Larsen, H.C., Yáñez, A.J.   +14 more
core   +1 more source

Pseudomonas aeruginosa exotoxin A as a novel allergen induced Non-TH2 inflammation in a murine model of steroid-insensitive asthma

Heliyon
Background: Despite the immediate in vivo occurrence of anaphylactic and allergic reactions following treatment with Pseudomonas aeruginosa exotoxin A (PEA)-based immunotoxins, the immunological role of PEA in asthma pathogenesis remains unclear ...
Huancheng Xie, Linmei Li, Yuhe Guo, Linghui Zhou, Linyi Ma, Andong He, He Lai, Ying He, Yongping Liu, Huifang Chen, Liping Luo, Yuyi Huang, Xiangyin Sha, Huanping Zhang, Jie Yan, Qingling Zhang, Ailin Tao   +16 more
doaj   +1 more source