Results 91 to 100 of about 113,972,927 (185)

Investigation of catalytic loops of Pseudomonas aeruginosa exotoxin A

, 2006
Pseudomonas aeruginosa exotoxin' A (ETA) catalyzes the transfer of the ADP-ribose moiety from NAD+ to its target protein, eukaryotic elongation factor 2 (eEF2).
Liu, Xiaobo
core   +1 more source

Molecular Detection of tox A Gene in Multidrug Resistance Pseudomonas aeruginosa Isolated from Burn Infections

Medical Journal of Babylon
Background: Exotoxin A (ExoA) is the most widespread and toxic virulence agent among pathogenic Pseudomonas aeruginosa species that acquire adenosine diphosphate-ribosyltransferase activity belonging to the class of exotoxins secreted by pathogenic ...
Zahraa Hamza Merza, Rabab Omran
doaj   +1 more source

Pseudomonas aeruginosa exotoxin A as a novel allergen induced Non-TH2 inflammation in a murine model of steroid-insensitive asthma

Heliyon
Background: Despite the immediate in vivo occurrence of anaphylactic and allergic reactions following treatment with Pseudomonas aeruginosa exotoxin A (PEA)-based immunotoxins, the immunological role of PEA in asthma pathogenesis remains unclear ...
Huancheng Xie, Linmei Li, Yuhe Guo, Linghui Zhou, Linyi Ma, Andong He, He Lai, Ying He, Yongping Liu, Huifang Chen, Liping Luo, Yuyi Huang, Xiangyin Sha, Huanping Zhang, Jie Yan, Qingling Zhang, Ailin Tao   +16 more
doaj   +1 more source

Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.

PLoS ONE, 2012
Homologs of the transcriptional regulator PtxS are omnipresent in Pseudomonas, whereas PtxR homologues are exclusively found in human pathogenic Pseudomonas species.
Abdelali Daddaoua, Sandy Fillet, Matilde Fernández, Zulema Udaondo, Tino Krell, Juan L Ramos   +5 more
doaj   +1 more source

Evaluating the influence of common antibiotics on the efficacy of a recombinant immunotoxin in tissue culture

BMC Research Notes, 2019
Objective Recombinant immunotoxins (RITs) are antibody-toxin fusion proteins that can selectively eliminate populations of cells expressing specific surface receptors. They are in evaluation as therapeutic agents for cancer.
Yuyi Zhu, John E. Weldon
doaj   +1 more source

Reduced cytotoxicity by mutation of lysine 590 of Pseudomonas exotoxin can be restored in an optimized, lysine-free immunotoxin. [PDF]

Immunother Adv, 2022
Ammon A, Mellenthin L, Emmerich C, Naschberger E, Stürzl M, Mackensen A, Müller F, Müller F.   +7 more
europepmc   +1 more source

Analysis of the Pseudomonas aeruginosa exotoxin A regulatory gene, ptxS [PDF]

, 2000
Exotoxin A production in Pseudomonas aeruginosa is a complex, highly regulated process which includes both environmental and genetic factors. Several genes have been identified which increase the expression of exotoxin A, the most prominent being regAB ...
Swanson, Britta L.
core  

Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production [PDF]

, 1997
Production of exotoxin A, the most toxic of the virulence factors produced by the opportunistic pathogen Pseudomonas aeruginosa, is a complicated, highly regulated process involving several genes.
Colmer, Jane Ann
core  

Otoprotectant minimizes hearing defects caused by Pseudomonas aeruginosa exotoxin A

, 2000
Exotoxin A, produced by Pseudomonas aeruginosa (PaExoA), penetrates from the middle ear in to the cochlea and causes sensorineural hearing loss (SNHL). In this investigation we studied electrophysiological changes in the albino rat following instillation
Popa, Raul,, Takumida, Masaya,, Anniko, Matti,   +2 more
core   +4 more sources

The cytotoxicity of Pseudomonas exotoxin A, inactivated by modification of the cell-binding domain I, is restored when conjugated to an erythroid cell-specific targeting agent.

, 1990
International audienceTo be capable of selective killing of tumor cells, the non-selective Pseudomonas aeruginosa exotoxin A must have its cell-binding domain inactivated or removed and then be chemically linked to, or genetically fused with, a specific ...
Guinand, M., Durkin, Jp, Whitfield, Jf, Ristic, A., Michel, G., Bourdenet, S., Doyonnas, R., Cozzone, Aj, Fasciotto, B., Vacheron, Mj   +9 more
core   +2 more sources