Results 91 to 100 of about 14,191 (208)

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]

, 2017
The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C, Ingolia, Nicholas T, Vance, Russell E   +2 more
core   +3 more sources

[Pseudomonas aeruginosa exotoxin].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1983
Different P. aeruginosa strains have been found to differ in exotoxin synthesis. The strain isolated at the Mechnikov Research Institute for Vaccines and Sera (Moscow) and newly isolated cultures obtained from patients with the severe course of the infectious process have been found to possess the highest toxigenic activity and to synthesize exotoxins ...
M N, Ianishevskaia, N S, Kuz'mina, V K, Golshmid   +2 more
openaire   +1 more source

The Immunomodulatory Effect of Recombinant Exotoxin A of Pseudomonas Aeruginosa on Dendritic Cells Extracted from Mice Spleen

Journal of Fasa University of Medical Sciences, 2015
Background & Objective: Dendritic cell (DC) is as a key cell in activation of immune response against microbes and disease. Therefore, the effect of recombinant exotoxin A of Pseudomonas aeruginosa on the maturity and the activation of DCs was evaluated ...
Mohammad Hossein Karimi, Aziz Japoni, Manouchehr Rasouli, Salimeh Ebrahimnezhad   +3 more
doaj  

Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis [PDF]

, 2012
Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action.
Cámara, Miguel, Hurley, M.N., Smyth, Alan R.   +2 more
core   +2 more sources

LRP1B functions as a receptor for Pseudomonas exotoxin

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2005
Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor.
Pastrana, Diana V., Hanson, Alison J., Knisely, Jane, Bu, Guojun, FitzGerald, David J.   +4 more
openaire   +3 more sources

Cloning and expression of the immunogenic moiety of Pseudomonas aeruginosa exotoxin A

Biological Journal of Microorganism, 2013
Introduction: Pseudomonas aeruginosa, as an opportunistic microorganism, is a major cause of nosocomial infections worldwide. Exotoxin A (ETA) is an extracellular enzyme that is produced by most clinical strains of P. aeruginosa.
Sahar Nouri Gharajelar *, Malahat Ahmadi, Bahman Hosseini   +2 more
doaj  

Molecular Detection of Virulence Genes among Pseudomonas aeruginosa Strains Isolated from Clinical Specimens by Multiplex PCR

پزشکی بالینی ابن سینا, 2018
Background and Objective: Pseudomonas aeroginosa is the most common pathogen associated with nosocomial infections and possesses virulence factors which contribute to the bacterial invasion and toxicity such as alginate, exoenzyme S, exotoxin A and ...
Afsoon Shariat, Sajad Alizadeh, Mehdi Jahangiri Hoseinabadi, Mohammad Movagharnejad   +3 more
doaj  

Molecular detection of virulence factors and biofilm formation in Pseudomonas aeruginosa obtained from different clinical specimens in Bandar Abbas

Iranian Journal of Microbiology, 2019
Background and Objectives: Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen. The presence of several virulence factors such as exotoxin and exoenzyme genes and biofilm may contribute to its pathogenicity.
Nima Bahador, Saeed Shoja, Foroogh Faridi, Banafsheh Dozandeh-Mobarrez, Fatemeh Izadpanah Qeshmi, Sedigheh Javadpour, Sedigheh Mokhtary   +6 more
doaj   +1 more source

Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts [PDF]

, 2014
OBJECTIVE: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.
Agreus, Lars, Andreasson, Anna, Assadi, Ghazaleh, Barbara, Giovanni, Barbaro, Raffaella, Bellini, Massimo, Blandizzi, Corrado, Boeckxstaens, Guy, Bresso, Francesca, Burwinkel, Barbara, Camilleri, Michael, Colucci, Rocchina Lucia, D'Amato, Mauro, Daly, Mark J., Dlugosz, Aldona, Ek, Weronica E., Gambaccini, Dario, Gazouli, Maria, Holliday, Elizabeth G., Houghton, Lesley, Karamanolis, George, Karling, Pontus, Li, Ling, Lindberg, Greger, Magnusson, Patrik, Marchi, Santino, Niesler, Beate, Ohlsson, Bodil, Papadaki, Evangelia, Pedersen, Nancy L., Rafter, Joseph, Rappold, Gudrun, Reznichenko, Anna, Ripke, Stephan, Rivera, Natalia V., Schmidt, Peter T., Simren, Magnus, Stanghellini, Vincenzo, Surowy, Harald, Talley, Nicholas J., Tornblom, Hans, Walter, Susanna, Wouters, Mira M., Zucchelli, Marco   +43 more
core   +1 more source

A bacterial exotoxin-triggered plant immune response restricts pathogen growth

Cell Reports
Summary: For optimal growth and development, hosts must promote healthy symbiotic interactions while restricting pathogens. To ask whether hosts can distinguish phylogenetically similar pathogens and beneficial bacteria, we used two closely related plant
David Thoms, Melissa Y. Chen, Yang Liu, Leah Fulton, Youqing Luo, Daniel E. Hiott, Siyu Song, Zayda Morales Moreira, Nicole R. Wang, Diego Zorio, Martin Rejzek, Ryan Potter, Philip Carella, Cara H. Haney   +13 more
doaj   +1 more source