Results 41 to 50 of about 21,006 (273)

The Neuropathic Itch Caused by Pseudorabies Virus [PDF]

Pathogens, 2020
Pseudorabies virus (PRV) is an alphaherpesvirus related to varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV1). PRV is the causative agent of Aujeskzy’s disease in swine. PRV infects mucosal epithelium and the peripheral nervous system (PNS) of its host where it can establish a quiescent, latent infection.
Laval, Kathlyn, Enquist, Lynn W.
openaire   +3 more sources

Tk-deleted pseudorabies virus retains high pathogenicity in rats

Journal of Veterinary Research, 2021
The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion.
Zhang Lirong, Ruan Keyue, Sang Guoju, Xu Zhaoyang, Tong Wu, Yu Hai, Shan Tongling, Gao Fei, Li Liwei, Kong Ning, Tong Guangzhi, Zheng Hao   +11 more
doaj   +1 more source

A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1/Th2 Immune Responses in Mice

Journal of Immunology Research, 2020
Pseudorabies is an important infectious disease of swine, and immunization using attenuated pseudorabies virus (aPrV) vaccine is a routine practice to control this disease in swine herds.
Yong Wang, Xuemei Cui, Lijia Yuan, Babar Maqbool, Wei Xu, Shanshan He, Ran Guan, Songhua Hu   +7 more
doaj   +1 more source

Interferon alpha suppresses alphaherpesvirus immediate early protein levels in sensory neurons, leading to the establishment of a latent infection [PDF]

, 2010
Alphaherpesviruses are a subfamily of the herpesviruses containing closely related human and animal pathogens, including human herpes simplex virus (HSV-1) and porcine pseudorabies virus (PRV)
De Regge, Nick, Favoreel, Herman, Peelman, Luc, Van Opdenbosch, Nina, Van Poucke, Mario   +4 more
core  

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

A gD&gC-substituted pseudorabies virus vaccine strain provides complete clinical protection and is helpful to prevent virus shedding against challenge by a Chinese pseudorabies variant

BMC Veterinary Research, 2019
Background Since 2011, pseudorabies caused by a variant PRV has re-emerged in many Chinese Bartha-K61-vaccinated pig farms. An efficacious vaccine is necessary to control this disease.
Chuanjian Zhang, Yamei Liu, Saisai Chen, Yongfeng Qiao, Mingpeng Guo, Yating Zheng, Mengwei Xu, Zhisheng Wang, Jibo Hou, Jichun Wang   +9 more
doaj   +1 more source

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai, BM Bradley, C Bourdon-Wouters, C Han, D Quan, DH Gilden, DW Wareham, Edward G. Rowan, EM Garry, Esther Grinfeld, Fiona Scott, FS Hasnie, FT Scott, G Ashrafi, G. H. Ashrafi, J Fogh, J Lai, JD Markman, JN Wood, Joseph Charles Glorioso, Judith Breuer, MA Hamza, MH Meisler, MJ Craner, MJ Quinlivan, ML Szpara, N Storey, Paul Montague, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PR Kinchington, R Dabby, R Mahalingam, RG Dalziel, RL Finnen, S Schünemann, SG Waxman, SJ Medhurst, SM Fleetwood-Walker, TR Cummins, W Peng, WA Catterall, X Zhou   +44 more
core   +3 more sources

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

Biotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal, Asingsa W. Arachchige, Annabelle J. Zahn, S. Ranil Wickramasinghe, Xianghong Qian, Andrew L. Zydney   +5 more
wiley   +1 more source

Analysis of differential gene expression in the brain tissue transcriptome of Jiangkou radish piglets infected with porcine pseudorabies virus

SAGE Open Medicine
Background: The research focused on the effects of pseudorabies virus on gene expression in piglet brain tissue. Objectives: The goal was to understand the changes in gene expression in piglet brains due to pseudorabies virus infection. Design: The study
Wei Sun, Shan-Shan Liu, Yu Fan, Sheng-Qing Deng, Hua-Qi Zhang, Fengzhao Zhu, Shi-He Long, Tao-Hua Ren, Ling Bai   +8 more
doaj   +1 more source

Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]

, 2019
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid, Couck, Liesbeth, Favoreel, Herman, Laval, Kathlyn, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien, Van Den Broeck, Wim   +7 more
core   +1 more source