Results 151 to 160 of about 2,435 (185)
ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH
Molecular Therapy, 2023 The role of Abraxas 2 (ABRO1 or KIAA0157), a component of the lysine63-linked deubiquitinating system, in the cardiomyocyte proliferation and myocardial regeneration is unknown. Here, we found that ABRO1 regulates cardiomyocyte proliferation and cardiac regeneration in the postnatal heart by targeting METTL3-mediated m6A methylation of Psph mRNA.
Xin-Zhe Chen, Cui-Yun Liu, Kao-Wen Yan
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Oncogene, 2021 Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples. PSPH knockdown using short hairpin RNAs (shRNAs) blocks melanoma tumor growth and metastasis in both cell culture and ...
Romi Gupta, Xuchen Zhang, Eddy S Yang
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Effect of PSPH on Angiogenesis and Migration of Hepatocellular Carcinoma Cells
2022 14th International Conference on Bioinformatics and Biomedical Technology, 2022Duo Zheng, Fujian Wan
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PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways [PDF]
International Journal of Biological Sciences, 2019 Growing evidence indicates that phosphoserine phosphatase (PSPH) is up-regulated and correlates with prognosis in multiple types of cancer. However, little is known about the roles of PSPH in NSCLC. Thus, the aim of the present study was to demonstrate the expression of PSPH in human NSCLC and reveal its biological functions and the underlying ...
Xinli Zhou, Liang Xiaohua, Li Liao
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Molecular Neurobiology
Diabetes-associated cognitive dysfunction (DACD) has ascended to become the second leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a pivotal rate-limiting enzyme in L-serine biosynthesis, has been documented to instigate the insulin signaling pathway through dephosphorylation.
Hongli Ma, Qiang Wang, Li Yansong
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Diabetes-associated cognitive dysfunction (DACD) has ascended to become the second leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a pivotal rate-limiting enzyme in L-serine biosynthesis, has been documented to instigate the insulin signaling pathway through dephosphorylation.
Hongli Ma, Qiang Wang, Li Yansong
exaly +3 more sources
Biochemical Pharmacology
Increasing evidence indicates that phosphoserine phosphatase (PSPH) promotes tumorigenesis in certain types of cancer. However, its specific role and regulatory mechanism in bladder cancer (BCa) remain unknown. In this study, we found that the expression level of PSPH is significantly upregulated in BCa tissues and patients with high PSPH levels ...
Zhikun Lin
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Increasing evidence indicates that phosphoserine phosphatase (PSPH) promotes tumorigenesis in certain types of cancer. However, its specific role and regulatory mechanism in bladder cancer (BCa) remain unknown. In this study, we found that the expression level of PSPH is significantly upregulated in BCa tissues and patients with high PSPH levels ...
Zhikun Lin
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l-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of l-serine biosynthesis [PDF]
Journal of Dermatological Science, 2011 L-3-Phosphoserine phosphatase (PSPH) is a highly conserved and widely expressed member of the haloacid dehalogenase superfamily and the rate-limiting enzyme in l-serine biosynthesis. We previously found Psph expression to be uniquely upregulated in a α6β4 integrin transgenic mouse model that is predisposed to epidermal hyperproliferation and squamous ...
Michael A, Bachelor +2 more
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Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures
Nature Chemical BiologyTemporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy. Lowering the levels of N-methyl-D-aspartate receptor (NMDAR) ligands has been suggested as a promising therapeutic strategy for TLE. D-Serine gates synaptic NMDARs in the hippocampus but the effect of D-serine on seizure activity remains poorly understood.
Longze Sha, Qi Xu, Yousong Ye
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Comparative analysis of the effects of PSPH and PHGDH inhibitors on tumor cell proliferation
Investigational New DrugsAbstract Serine metabolism plays a critical role in supporting the rapid proliferation of tumor cells, with PHGDH recognized as a key rate-limiting enzyme and therapeutic target. However, whether its antitumor effects are solely dependent on serine metabolism remains under debate. In this study, we systematically compared the effects of
Longze Sha
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