Results 151 to 160 of about 2,361 (179)

l-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of l-serine biosynthesis [PDF]

Journal of Dermatological Science, 2011
L-3-Phosphoserine phosphatase (PSPH) is a highly conserved and widely expressed member of the haloacid dehalogenase superfamily and the rate-limiting enzyme in l-serine biosynthesis. We previously found Psph expression to be uniquely upregulated in a α6β4 integrin transgenic mouse model that is predisposed to epidermal hyperproliferation and squamous ...
David M Owens
exaly   +3 more sources

PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways [PDF]

International Journal of Biological Sciences, 2019
Growing evidence indicates that phosphoserine phosphatase (PSPH) is up-regulated and correlates with prognosis in multiple types of cancer. However, little is known about the roles of PSPH in NSCLC. Thus, the aim of the present study was to demonstrate the expression of PSPH in human NSCLC and reveal its biological functions and the underlying ...
Xinli Zhou, Mengxi Ge, Ruofan Huang
exaly   +3 more sources

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Targeting BACH1/PSPH axis suppresses bladder cancer progression and gemcitabine resistance by downregulating S100A2 expression

Biochemical Pharmacology
Increasing evidence indicates that phosphoserine phosphatase (PSPH) promotes tumorigenesis in certain types of cancer. However, its specific role and regulatory mechanism in bladder cancer (BCa) remain unknown. In this study, we found that the expression level of PSPH is significantly upregulated in BCa tissues and patients with high PSPH levels ...
Chuanchun Han, Xishuang Song, Zhikun Lin   +2 more
exaly   +3 more sources

Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice

Molecular Neurobiology
Diabetes-associated cognitive dysfunction (DACD) has ascended to become the second leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a pivotal rate-limiting enzyme in L-serine biosynthesis, has been documented to instigate the insulin signaling pathway through dephosphorylation.
Qiang Wang, Shuxuan He, Haiqing Chang
exaly   +3 more sources

Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures

Nature Chemical Biology
Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy. Lowering the levels of N-methyl-D-aspartate receptor (NMDAR) ligands has been suggested as a promising therapeutic strategy for TLE. D-Serine gates synaptic NMDARs in the hippocampus but the effect of D-serine on seizure activity remains poorly understood.
Yu Deng, Longze Sha, Qi Xu
exaly   +3 more sources

Novel association of PhosphoSerine PHosphatase (PSPH) gene mutations with male infertility identified through whole exome sequencing of South Indians

Meta Gene, 2021
Abstract Male infertility (MI) is mainly caused by spermatogenic failure, and despite long years of assisted reproductive therapy, a significant number of cases remain idiopathic. Oligoasthenozoospermia (OA) is one of the most severe idiopathic MI forms, conditioned with decreased sperm motility and count.
Golnaz Shemshaki, Mohsen Najafi, Ashitha S. Niranjana Murthy, Suttur S. Malini   +3 more
openaire   +1 more source

Integrated of multi-omics and molecular docking reveal PHGDH, PSAT1 and PSPH in the serine synthetic pathway as potential targets of T-2 toxin exposure in pig intestinal tract

International Journal of Biological Macromolecules, 2023
T-2 toxin (T-2) with a molecular weight of 466.52 g/mol is an inevitable mycotoxin in food products and feeds, posing a significant threat to human and animal health. However, the underlying molecular mechanisms of the cytotoxic effects of T-2 exposure on porcine intestinal epithelial cells (IPEC-J2) remain unclear.
Wenbin Bao, Yin Zongjun, Haifei Wang
exaly   +3 more sources

NRF2-SOX4 complex regulates PSPH in hepatocellular carcinoma and modulates M2 macrophage differentiation

Cancer Gene Therapy
Hepatocellular carcinoma (HCC) progression is tightly linked to metabolic reprogramming and immune evasion. However, the transcriptional networks driving these processes remain misunderstood. Here, we identified a novel regulatory axis wherein the transcription factor SOX4 formed a stress-responsive complex with NRF2, as confirmed by co ...
Chi-Neu Tsai, Ming-Chin Yu, Chia-Lung Tsai   +2 more
exaly   +3 more sources

Comparative analysis of the effects of PSPH and PHGDH inhibitors on tumor cell proliferation

Investigational New Drugs
Abstract Serine metabolism plays a critical role in supporting the rapid proliferation of tumor cells, with PHGDH recognized as a key rate-limiting enzyme and therapeutic target. However, whether its antitumor effects are solely dependent on serine metabolism remains under debate. In this study, we systematically compared the effects of
Yanbing, Wang, Longze, Sha
exaly   +3 more sources

PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway

Cell Biology International, 2020
AbstractPhosphoserine phosphatase (PSPH), a key enzyme of the l‐serine synthesis pathway, has been involved in cancer progression and survival. However, limited evidence revealed the PSPH influence on hepatocellular carcinoma (HCC). Herein, we observed that PSPH expression was upregulated in both HCC tissues and cell lines, which was determined by ...
Jianli Zhang, Erhao Wang, Lei Zhang, Bo Zhou   +3 more
openaire   +2 more sources