Results 161 to 170 of about 2,250 (188)
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Effect of PSPH on Angiogenesis and Migration of Hepatocellular Carcinoma Cells
2022 14th International Conference on Bioinformatics and Biomedical Technology, 2022Fujian Wan
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l-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of l-serine biosynthesis [PDF]
Journal of Dermatological Science, 2011 L-3-Phosphoserine phosphatase (PSPH) is a highly conserved and widely expressed member of the haloacid dehalogenase superfamily and the rate-limiting enzyme in l-serine biosynthesis. We previously found Psph expression to be uniquely upregulated in a α6β4 integrin transgenic mouse model that is predisposed to epidermal hyperproliferation and squamous ...
David M Owens
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PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways [PDF]
International Journal of Biological Sciences, 2019 Growing evidence indicates that phosphoserine phosphatase (PSPH) is up-regulated and correlates with prognosis in multiple types of cancer. However, little is known about the roles of PSPH in NSCLC. Thus, the aim of the present study was to demonstrate the expression of PSPH in human NSCLC and reveal its biological functions and the underlying ...
Li Liao, Mengxi Ge, Qiong Zhan
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Comparative analysis of the effects of PSPH and PHGDH inhibitors on tumor cell proliferation
Investigational New DrugsAbstract Serine metabolism plays a critical role in supporting the rapid proliferation of tumor cells, with PHGDH recognized as a key rate-limiting enzyme and therapeutic target. However, whether its antitumor effects are solely dependent on serine metabolism remains under debate. In this study, we systematically compared the effects of
Longze Sha
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International Journal of Biological Macromolecules, 2023
T-2 toxin (T-2) with a molecular weight of 466.52 g/mol is an inevitable mycotoxin in food products and feeds, posing a significant threat to human and animal health. However, the underlying molecular mechanisms of the cytotoxic effects of T-2 exposure on porcine intestinal epithelial cells (IPEC-J2) remain unclear.
Zhengchang Wu +2 more
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T-2 toxin (T-2) with a molecular weight of 466.52 g/mol is an inevitable mycotoxin in food products and feeds, posing a significant threat to human and animal health. However, the underlying molecular mechanisms of the cytotoxic effects of T-2 exposure on porcine intestinal epithelial cells (IPEC-J2) remain unclear.
Zhengchang Wu +2 more
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Meta Gene, 2021
Abstract Male infertility (MI) is mainly caused by spermatogenic failure, and despite long years of assisted reproductive therapy, a significant number of cases remain idiopathic. Oligoasthenozoospermia (OA) is one of the most severe idiopathic MI forms, conditioned with decreased sperm motility and count.
Golnaz Shemshaki +3 more
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Abstract Male infertility (MI) is mainly caused by spermatogenic failure, and despite long years of assisted reproductive therapy, a significant number of cases remain idiopathic. Oligoasthenozoospermia (OA) is one of the most severe idiopathic MI forms, conditioned with decreased sperm motility and count.
Golnaz Shemshaki +3 more
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Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures
Nature Chemical BiologyTemporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy. Lowering the levels of N-methyl-D-aspartate receptor (NMDAR) ligands has been suggested as a promising therapeutic strategy for TLE. D-Serine gates synaptic NMDARs in the hippocampus but the effect of D-serine on seizure activity remains poorly understood.
Longze Sha, Yu Deng, Qi Xu
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Biochemical Pharmacology
Increasing evidence indicates that phosphoserine phosphatase (PSPH) promotes tumorigenesis in certain types of cancer. However, its specific role and regulatory mechanism in bladder cancer (BCa) remain unknown. In this study, we found that the expression level of PSPH is significantly upregulated in BCa tissues and patients with high PSPH levels ...
Chuanchun Han, Zhikun Lin
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Increasing evidence indicates that phosphoserine phosphatase (PSPH) promotes tumorigenesis in certain types of cancer. However, its specific role and regulatory mechanism in bladder cancer (BCa) remain unknown. In this study, we found that the expression level of PSPH is significantly upregulated in BCa tissues and patients with high PSPH levels ...
Chuanchun Han, Zhikun Lin
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Molecular Neurobiology
Diabetes-associated cognitive dysfunction (DACD) has ascended to become the second leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a pivotal rate-limiting enzyme in L-serine biosynthesis, has been documented to instigate the insulin signaling pathway through dephosphorylation.
Shuxuan He +2 more
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Diabetes-associated cognitive dysfunction (DACD) has ascended to become the second leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a pivotal rate-limiting enzyme in L-serine biosynthesis, has been documented to instigate the insulin signaling pathway through dephosphorylation.
Shuxuan He +2 more
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Cancer Gene Therapy
Hepatocellular carcinoma (HCC) progression is tightly linked to metabolic reprogramming and immune evasion. However, the transcriptional networks driving these processes remain misunderstood. Here, we identified a novel regulatory axis wherein the transcription factor SOX4 formed a stress-responsive complex with NRF2, as confirmed by co ...
Chia-Lung Tsai +2 more
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Hepatocellular carcinoma (HCC) progression is tightly linked to metabolic reprogramming and immune evasion. However, the transcriptional networks driving these processes remain misunderstood. Here, we identified a novel regulatory axis wherein the transcription factor SOX4 formed a stress-responsive complex with NRF2, as confirmed by co ...
Chia-Lung Tsai +2 more
exaly +3 more sources