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PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway

Cell Biology International, 2020
AbstractPhosphoserine phosphatase (PSPH), a key enzyme of the l‐serine synthesis pathway, has been involved in cancer progression and survival. However, limited evidence revealed the PSPH influence on hepatocellular carcinoma (HCC). Herein, we observed that PSPH expression was upregulated in both HCC tissues and cell lines, which was determined by ...
Jianli Zhang, Erhao Wang, Lei Zhang, Bo Zhou +3 more
openaire +2 more sources

PSPH promotes colorectal cancer growth by triggering autophagy through AMPK-ULK1 activation and enhancing tumor immune evasion

General Physiology and Biophysics
Phosphoserine phosphatase (PSPH), a key enzyme in the L-serine synthesis pathway, has been found to promote cancer progression through autophagy modulation. Here, we explored the functional role and molecular mechanisms of PSPH in colorectal cancer (CRC).
Jiajia, Guan +5 more
exaly +3 more sources

Abstract 773: Overexpression of phosphoserine phosphatase (PSPH) in prostate cancer and in tumor microenvironment promotes tumor cell proliferation

Cancer Research
Abstract Reprogrammed cellular metabolism is one of the key features of cancer and tumor microenvironment. L-3-phosphoserine phosphatase (PSPH) is one of the five rate-limiting enzymes in the biosynthesis of serine from glucose that supports cell proliferation. Here, we aim to study the role of PSPH in prostate cancer (PCa) and its tumor
Liankun Song +10 more
openaire +1 more source

Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan