Results 51 to 60 of about 499,109 (301)

Study on Phase Ⅰ Metabolism of 2-(Benzylamino)-1-Phenylheptan-1-One in Human Liver Microsomes Based on Ultra Performance Liquid Chromatography-High Resolution Tandem Mass Spectrometry

Zhongguo sifa jianding
Objective 2-(benzylamino)-1-phenylheptan-1-one is a novel synthetic cathinone derivative that has emerged in recent years, and its metabolic pathways and metabolites remain unclear. This study aims to elucidate its in vitro metabolic characteristics and
SHAN Yabing, WANG Chen, JIA Rui, SONG Chunhui, LI Jiayi, CHEN Ying, ZENG Xianbin, HUA Zhendong, LI Dongmei, LIU Cuimei   +9 more
doaj   +1 more source

Psychedelic Fauna for Psychonaut Hunters: A Mini-Review

Frontiers in Psychiatry, 2018
Currently different classes of psychoactive substances are easily available for abuse, including several hundred novel psychoactive substances (NPS).
Laura Orsolini, Laura Orsolini, Laura Orsolini, Michela Ciccarese, Duccio Papanti, Domenico De Berardis, Domenico De Berardis, Domenico De Berardis, Amira Guirguis, John M. Corkery, Fabrizio Schifano   +10 more
doaj   +1 more source

Genotoxic Aspects of Psychoactive Substances

, 2022
Exposure to psychoactive substances is undoubtedly a serious public health issue that should be carefully analyzed from different perspectives. Regarding the types of toxic effects inflicted by these xenobiotics, it is already known that many of the ...
Ricardo Jorge Dinis-Oliveira, Nuno G. Oliveira   +1 more
core   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

The Bridge Between Classical and “Synthetic”/Chemical Psychoses: Towards a Clinical, Psychopathological, and Therapeutic Perspective

Frontiers in Psychiatry, 2019
The critical spread and dissemination of novel psychoactive substances (NPS), particularly among the most vulnerable youngsters, may pose a further concern about the psychotic trajectories related to the intake of new synthetic drugs.
Laura Orsolini, Laura Orsolini, Laura Orsolini, Stefania Chiappini, Duccio Papanti, Domenico De Berardis, Domenico De Berardis, Domenico De Berardis, John M. Corkery, Fabrizio Schifano   +9 more
doaj   +1 more source

Exploring the Baseline Knowledge and Experience of Healthcare Professionals in the United Kingdom on Novel Psychoactive Substances

Brain Sciences, 2020
Objective: This survey aimed to explore knowledge and experience on novel psychoactive substances (NPS) of healthcare professionals (HCPs). The study also aimed to assess how HCPs would like to improve their knowledge of NPS.
Camille Ramos, Amira Guirguis, Nigel Smeeton, Hadar Zaman, Anna-Marie Felice, Stephanie Bancroft, Rosalind Gittins, Gill Hawksworth, John Martin Corkery, Fabrizio Schifano   +9 more
doaj   +1 more source

New psychoactive substances in Poland. The analysis of policy responses and its effects

, 2017
Introduction : The aim of this article is to analyse the process of creation and implementation of policy on new psychoactive substances (NPS) in Poland in the context of definitional and legal issues, social and market response, implementation of ...
Michał Bujalski, Łukasz Wieczorek, Katarzyna Dąbrowska   +2 more
core   +1 more source

Monitoring risk behaviour in adolescent pupils regarding consumption of psychoactive substances [PDF]

, 2017
Introduction Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. Objectives To estimate the amount and incidence of drug consumption in middle and high school pupils ...
Paulina Wojtyła-Buciora, Ewa Ulatowska-Szostak, Ulatowska-Szostak, Ewa, Marcinkowski, Jerzy T., Andrzej Wojtyła, Bołdowski, Tomasz, Kapka-Skrzypczak, Lucyna Kapka-Skrzypczak, Wojtyła-Buciora, Paulina, Diatczyk, Jarosław, Aneta Klimberg, Jarosław Diatczyk, Tomasz Bołdowski, Klimberg, Aneta, Monika Urbaniak, Jerzy T Marcinkowski, Urbaniak, Monika, Lucyna Kapka-Skrzypczak, Wojtyła, Andrzej   +17 more
core   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source