Synthesis of 6-Hydroxymethylpterin α- and β-D-Glucosides [PDF]
, 2010 The key precursor, N(2)-(N,N-dimethylaminomethylene)-6-hydroxymethyl-3-[2-(4-nitrophenyl)ethyl]pterin (11) was efficiently prepared from 2,5,6-triamino-4-hydroxypyrimidine (8) in 5 steps.
Baba, Hiroki +3 more
core +1 more source
Theoretical Study on the Relative Energies of Neutral Pterin Tautomers
Pteridines, 2008 Current literature lists the lactam and lactim tautomers as the only major contributors to aqueous pterin structures. Density functional theory calculations were used to determine whether there are other significant neutral tautomers of pterin ...
Soniat Michael, Martin Christopher B.
doaj +1 more source
Tryptophan oxidation photosensitized by pterin
Free Radical Biology and Medicine, 2013 Pterins are normal components of cells and they have been previously identified as good photosensitizers under UV-A irradiation, inducing DNA damage and oxidation of nucleotides. In this work, we have investigated the ability of pterin (Ptr), the parent compound of oxidized pterins, to photosensitize the oxidation of another class of biomolecules ...
Thomas, Andrés +6 more
openaire +4 more sources
7‐Substituted pterins in humans with suspected pterin‐4a‐carbinolamine dehydratase deficiency [PDF]
European Journal of Biochemistry, 1992 A recently described new form of hyperphenylalaninemia is characterized by the excretion of 7‐substituted isomers of biopterin and neopterin and 7‐oxo‐biopterin in the urine of patients. It has been shown that the 7‐substituted isomers of biopterin and neopterin derive from L‐tetrahydrobiopterin and D‐tetrahydroneopterin and are formed during ...
Adler, Carmen +7 more
openaire +3 more sources
Inhibitory Effects of Pteridines on the Cytochrome P-450 Enzyme System
Pteridines, 1997 The effects of 17 different pteridine derivatives on rat liver microsomal cytochrome P-450 catalyzed degradation of aminoantipyrin were studied.
Horejsi Renate +5 more
doaj +1 more source
Identification of YdhV as the first molybdoenzyme binding a Bis-Mo-MPT cofactor in escherichia coli [PDF]
, 2019 The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Dau, Holger +7 more
core +1 more source
Plasma Levels of Neopterin and Biopterin in the Umbilical Vessels and the Maternal Vein
Pteridines, 2003 Tetrahydrobiopterin (BH4) is a highly bioactive pterin required for nitric oxide synthase and monooxygenases of aromatic amino acids, and is involved in the synthesis of nitric oxide, catecholamines and Serotonin.
Iwanaga Naoko +8 more
doaj +1 more source
Immunopterin: A prospective therapy and preventative to fight COVID-19?
Pteridines, 2022 The authors explore the therapeutic and prophylactic efficacies of Immunopterin (calcium pterin-6-carboxylate chelate) against coronavirus colds and as a therapy against COVID-19.
Moheno Phillip B. B., Fuchs Dietmar
doaj +1 more source
Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. [PDF]
, 2010 The crystal structure of Dhaf4260 from Desulfitobacterium hafniense DCB-2 was determined by single-wavelength anomalous diffraction (SAD) to a resolution of 2.01 Å using the semi-automated high-throughput pipeline of the Joint Center for Structural ...
Abdubek, Polat +37 more
core +3 more sources
Molecular architecture of pterin deaminase from Saccharomyces cerevisiae NCIM 3458
Pteridines, 2017 As early as 1974, reports have confirmed the anticancer activity of pterin deaminase isolated from fungi. The enzyme has also been reported in bacteria, fungi and slime mold genera, but the enzyme characterization was effetely done.
Murugesan Thandeeswaran +7 more
doaj +1 more source