Results 171 to 180 of about 8,097,471 (281)

Exercise intolerance and impaired aerobic capacity in heart transplant recipients

Experimental Physiology, EarlyView.
Abstract Heart transplant recipients exhibit reduced exercise tolerance and persistently diminished aerobic capacity despite exercise training. Exercise tolerance depends on integrated oxygen transport and utilization, which are impaired in heart transplant recipients.
Fred W. Kolkhorst, Daniel T. Cannon, Harry B. Rossiter   +2 more
wiley   +1 more source

Arterial tracing-based technique for rapid purification of pulmonary arterial smooth muscle cells from rat lungs. [PDF]

Physiol Rep
Pham L, Pavelich L, Sommer N, Grossman LI, Hüttemann M, Arroum T.   +5 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway. [PDF]

Bioengineered, 2022
Xu J, Zhong Y, Wang Z.
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Correction to: Hypoxia-induced histone lactylation promotes pulmonary arterial smooth muscle cells proliferation in pulmonary hypertension. [PDF]

Mol Cell Biochem
Chen A, Chen Z, Huang B, Lian G, Luo L, Xie L.   +5 more
europepmc   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

Mitochondrial acid-sensing ion channel 1a deficiency induces mitochondrial dysfunction in pulmonary arterial smooth muscle cells. [PDF]

Am J Physiol Lung Cell Mol Physiol
Tuineau MN, Herbert LM, Medina HE, Naik JS, Resta TC, Jernigan NL.   +5 more
europepmc   +1 more source

NF-κB/p65 Competes With Peroxisome Proliferator-Activated Receptor Gamma for Transient Receptor Potential Channel 6 in Hypoxia-Induced Human Pulmonary Arterial Smooth Muscle Cells. [PDF]

Front Cell Dev Biol, 2021
Wang Y, Li N, Wang Y, Zheng G, An J, Liu C, Wang Y, Liu Q.   +7 more
europepmc   +1 more source

Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle

, 2008
BKCa channels regulate pulmonary arterial pressure, and protein kinase C (PKC) inhibits BKCa channels, but little is known about PKC-mediated modulation of BKCa channel activity in pulmonary arterial smooth muscle.
Zhu, Shu, Barman, Scott A., White, Richard E.   +2 more
core