Results 141 to 150 of about 1,773,773 (285)

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Vascular remodeling in pulmonary hypertension [PDF]

, 2021
openaire   +1 more source

Versican accumulates in vascular lesions in pulmonary arterial hypertension

, 2016
Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance.
Chan, Christina K., Inger Eriksson, Cao, Xiaofang, Ya‐Ting Chang, Tran-Lundmark, Karin,, Xiaofang Cao, Andersson-Sjöland, Annika, Kjellen, Lena,, Kjellén, Lena, Andersson-Sjoland, Annika,, Pamela Y. Johnson, Johansson, Staffan,, Gunilla Westergren‐Thorsson, Johnson, Pamela Y., Ulf Hedin, Karin Tran‐Lundmark, Cao, Xiaofang,, Wight, Thomas N., Westergren-Thorsson, Gunilla, Westöö, Christian, Tran-Lundmark, Karin, Johansson, Staffan, Lena Kjellén, Christian Westöö, Eriksson, Inger,, Annika Andersson‐Sjöland, Christina K. Chan, Thomas N. Wight, Hedin, Ulf,, Wight, Thomas N.,, Christian Norvik, Chang, Ya-Ting,, Chan, Christina K.,, Johnson, Pamela Y.,, Norvik, Christian, Hedin, Ulf, Chang, Ya Ting, Westoo, Christian,, Norvik, Christian,, Westergren-Thorsson, Gunilla,, Staffan Johansson, Eriksson, Inger, Eriksson, I, Andersson-Sjoland, A, Johansson, S, Lund University., Westergren-Thorsson, G, Westoo, C, Cao, X, Chan, CK, Chang, Y-T, Chang, Ya Ting,, Johnson, PY, Norvik, C   +53 more
core   +1 more source

TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer

Advanced Science, EarlyView.
DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia, Shiyu Zhang, Yangbo Tang, Shinuo Chen, Xingxin Zhu, Junran Chen, Suchen Bian, Lei Zheng, Chi Zhang, Haojing Ma, Wengfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Qinglin Li, Penghong Song   +15 more
wiley   +1 more source

LFA‐1‐Engineered Extracellular Vesicles Deliver CD59 to Protect Endothelial Integrity in Acute Lung Injury

Advanced Science, EarlyView.
LFA‐1‐engineered extracellular vesicles preferentially target pulmonary endothelium and deliver CD59, thereby inhibiting membrane attack complex formation, preserving vascular integrity, and attenuating acute lung injury. This strategy reveals a targeted approach for protecting the pulmonary vasculature from complement‐mediated damage.
Yin Zhu, Shravani Etrouth, Payaningal R. Somanath, S. Priya Narayanan, Yutao Liu, Xiaoyun Wang, Duo Zhang   +6 more
wiley   +1 more source

Angiogenesis in Chronic Obstructive Pulmonary Disease [PDF]

, 2012
Angiogenesis is a crucial component of lung pathophysiology, not only in cancer but also in other disorders, such as chronic obstructive pulmonary disease (COPD).
Gaetano Santulli, Alessandro Matarese
core  

Advances in HFpEF Research Based on Characteristics of Older Adults

AGING MEDICINE, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) in older adults is a systemic, age‐related syndrome involving cardiac, vascular, metabolic, and skeletal muscle dysfunction. The interconnected triad of frailty, sarcopenia, and malnutrition contributes to exercise intolerance, functional decline, and adverse clinical outcomes through inflammation,
Rui Li, Rosnani hashim
wiley   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

Advanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò, Semproni Federica, Maselli Martina, Colli Andrea, Cianchetti Matteo, Ciuti Gastone, Stefanini Cesare, Menciassi Arianna   +7 more
wiley   +1 more source

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source