Results 171 to 180 of about 1,773,773 (285)

Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

BMEMat, EarlyView.
A nanomotor featuring an “electronic lock” via electron compensation in an Au‐Ag alloy ensures therapeutic precision. Near‐infrared light acts as a key, unlocking on‐demand Ag+ release for synergistic bactericidal action and microenvironment remodeling to potently treat bacterial pneumonia. Abstract Bacterial pneumonia treatment is severely hampered by
Chenglong Xue, Xiaoyu Zhao, Yuqian Wang, Lijin Shi, Qi Shuai   +4 more
wiley   +1 more source

The Role of Platelets in Pulmonary Hypertension: From Activation to Pulmonary Vascular Remodeling-A Review Article. [PDF]

Biomedicines
Wszelaki P, Karczmarska A, Szymoniuk S, Grześk G, Włodarczyk Z, Sikora J.   +5 more
europepmc   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Pulmonary Vascular and Right-Ventricular Remodeling in a Rat Model of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary pressures, irreversible vascular remodeling, and right ventricle (RV) hypertrophy.
Shaikh, Ahmad Rehan
core   +1 more source

Multimodal Framework of Left Heart-Pulmonary Vascular Remodeling Underlying Right Ventricular Failure in PH-HFpEF. [PDF]

Circ Heart Fail
Raza F, Gregorich ZR, Freeman J, Moore B, Houston TW, Garcia-Arango M, Lechuga CG, Chen Y, Sahai A, El Shaer A, Korcarz CE, Cui K, Park Y, Jones K, Tu W, Runo J, Schulte JJ, Nagpal P, Ge Y, Wieben O, Stewart R, Chesler NC, Guo W.   +22 more
europepmc   +1 more source

Early Experience With Evoque Transcatheter Tricuspid Valve Replacement in Carcinoid Heart Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Tricuspid regurgitation (TR) is nearly universal in carcinoid heart disease (CHD), but surgical replacement carries significant risk, and CHD was excluded from the landmark TRISCEND II trial. We present seven patients with CHD undergoing Evoque transcatheter tricuspid valve replacement (TTVR) at two tertiary centers.
Jackson S. Burton, Ben Peterson, Brian Whisenant, Anwar Tandar   +3 more
wiley   +1 more source

Pulmonary Vascular Remodeling in Smokers: A Systematic Review of Quantitative CT and Histologic Evidence. [PDF]

Cureus
Chhabra P, Enissi M, Asif E, Johal LK, Nasrat AK, Azhar N, Dar BA, Oloba MO, Azhar R, Haseeb A, Raza Bhutta A.   +10 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study. [PDF]

Circulation
Dewanjee A, Lamberson V, Yang Y, Giugni FR, Claggett BL, Matsushita K, Blaha MJ, Washko G, San José Estépar R, Nardelli P, San José Estépar R, Shah AM.   +11 more
europepmc   +1 more source