Results 211 to 220 of about 1,773,773 (285)

IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension. [PDF]

J Am Heart Assoc
Cai Z, Tu L, Tian S, Deng L, Fu Y, Phan C, van den Bosch TPP, Tran-Lundmark K, Nagy BM, Olschewski H, Li X, Wang S, Wang D, Yan Y, Fu L, Boomars KA, Guignabert C, Merkus D.   +17 more
europepmc   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Metabolic Reprogramming Intermediates of Glucose Regulate Macrophage Polarization: An Important Direction for Ameliorating Pulmonary Vascular Remodeling. [PDF]

J Inflamm Res
Wang J, Yuan R, Zhang S, Xu Z, Song L.
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension. [PDF]

JACC Basic Transl Sci
Shi JZ, Zhu YJ, Zhang MJ, Yan Y, Zhao LL, Zhang HD, Liu Y, Wu WH, Cheng Z, Qiu CG, Kou JJ, Zhou YF, Pang XB, Chen JW, Xie XM, He YY, Jing ZC.   +16 more
europepmc   +1 more source

Mechanical memory in aging: From adaptive sensing to pathological entrenchment

Interdisciplinary Medicine, EarlyView.
Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang, Xiaoyu Ma, Ruiqi Gao, Qichen Miao, Guoqing Wang, Ziyuan Liu, Kun Wang, Ming Luo   +7 more
wiley   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin-Mediated Regulation of ENO1. [PDF]

Adv Sci (Weinh)
Sun N, Wang YB, Huang J, Deng RW, He HY, Gao L, Gao X, Fan YL, Cong Y, Guo YL, Chen YQ, Wang GJ, Fang SH, Gu X, Yu B, Wu BX.   +15 more
europepmc   +1 more source

Association Between MRI‐Derived Right‐to‐Left Ventricular Volume Ratio and Regional Left Ventricular Myocardial Dysfunction in Patients With Pulmonary Arterial Hypertension

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Right ventricular (RV) to left ventricular (LV) end‐diastolic volume ratio (RV/LV) is a validated marker of RV dilation in pulmonary arterial hypertension (PAH), yet its impact on LV myocardial function and the underlying mediating pathway is incompletely characterized.
Han Fang, Yuan Li, Jin Wang, Wei‐Feng Yan, Ke Shi, Shi‐Qin Yu, Xue Li, Wen‐Rong Li, Jia‐Ke Li, Jing‐Yi Guo, Li Jiang, Zhi‐Gang Yang   +11 more
wiley   +1 more source

Does the Reversal and Normalization of Airway and Pulmonary Vascular Remodeling Accompany Asthma Remission? [PDF]

Chest
Mozaffaripour A, Tcherner S, McIntosh MJ, Kooner HK, Bhalla A, Serajeddini H, Yamashita C, Parraga G.   +7 more
europepmc   +1 more source