Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
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Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]
PLoS ONE, 2011 Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera +11 more
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Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice
Neurobiology of Disease, 2012 Inherited defects in purine nucleoside phosphorylase (PNP) cause severe T cell immunodeficiency and progressive neurological dysfunction, yet little is known about the effects of PNP deficiency on the brain.
Alireza Mansouri +9 more
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Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. [PDF]
PLoS ONE, 2014 Deoxyribosyl transferases and functionally related purine nucleoside phosphorylases are used extensively for synthesis of non-natural deoxynucleosides as pharmaceuticals or standards for characterizing and quantitating DNA adducts.
Wenjie Ye +10 more
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Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy [PDF]
, 2013 Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory ...
Dobolyi, Árpád, Kovács, Zsolt
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Energy metabolism during the maturation of reticulocyte in vitro [PDF]
, 1968 1. For the purpose to clarify the mechanism of the revolutional changes in energy metabolism during the reticulocyte maturation the metabolisms of glucose and of the pentose moieties of acid soluble nucleotides have been observed on rabbit reticulocytes ...
Hayashi, Kenji +5 more
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Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster [PDF]
, 2005 The multisubstrate nucleoside kinase of Drosophila melanogaster (Dm-dNK) can be expressed in human solid tumor cells and its unique enzymatic properties makes this enzyme a suicide gene candidate.
Balzarini, J +4 more
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Immunological Investigations, 2019 Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive primary immunodeficiency disorder characterized by decreased numbers of T-cells, variable B-cell abnormalities, decreased amount of serum uric acid and PNP enzyme activity ...
Saba Fekrvand +4 more
semanticscholar +1 more source
Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]
, 2016 BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea +4 more
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Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP
Molecules, 2023 The great interest in studying the structure of human purine nucleoside phosphorylase (hPNP) and the continued search for effective inhibitors is due to the importance of the enzyme as a target in the therapy of T-cell proliferative diseases. In addition,
Anastasia Khandazhinskaya +7 more
doaj +1 more source