Results 91 to 100 of about 19,457 (231)

Nucleotide degradation and ribose salvage in yeast

Molecular Systems Biology, 2013
Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway.
Yi‐Fan Xu, Fabien Létisse, Farnaz Absalan, Wenyun Lu, Ekaterina Kuznetsova, Greg Brown, Amy A Caudy, Alexander F Yakunin, James R Broach, Joshua D Rabinowitz   +9 more
doaj   +1 more source

The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis

Терапевтический архив, 2010
Aim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. Materials and methods.
Aleksandr Borisovich Zborovskiy, Elena Eduardovna Mozgovaya, Vladislav Fedorovich Martem'yanov, Ol'ga Petrovna Slyusar', Mikhail Yur'evich Stazharov, S A Bedina, A B Zborovsky, E E Mozgovaya, V F Martemyanov, O P Slyusar, M Yu Stazharov, S A Bedina   +11 more
doaj  

Efficient whole-cell biocatalytic synthesis of 2′-deoxy-2′-fluoroadenosine, a key building block for nucleic acid drugs

Synthetic and Systems Biotechnology
2′-Deoxy-2′-fluoroadenosine (2′-F-dA) is a nucleoside analogue used as a key building block for oligonucleotide drugs. It can be biosynthesized from a low-cost 2′-deoxy-2′-fluorouridine via one-pot transglycosylation catalyzed by a thymidine ...
Dandan Feng, Tianshu Zhang, Guan Zhou, Yanli Cao, Quan Luo, Huifang Xu, Xuefeng Lu   +6 more
doaj   +1 more source

An Efficient Chemoenzymatic Process for Preparation of Ribavirin

International Journal of Chemical Engineering, 2015
Ribavirin is an important antiviral drug, which is used for treatment of many diseases. The pilot-scale chemoenzymatic process for synthesis of the active pharmaceutical ingredient Ribavirin was developed with 32% overall yield and more than 99.5% purity.
Vladimir Sakharov, Sergey Baykov, Irina Konstantinova, Roman Esipov, Mikhail Dorogov   +4 more
doaj   +1 more source

Site-Selective Ribosylation of Fluorescent Nucleobase Analogs Using Purine-Nucleoside Phosphorylase as a Catalyst: Effects of Point Mutations

Molecules, 2015
Enzymatic ribosylation of fluorescent 8-azapurine derivatives, like 8-azaguanine and 2,6-diamino-8-azapurine, with purine-nucleoside phosphorylase (PNP) as a catalyst, leads to N9, N8, and N7-ribosides.
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Agnieszka Bzowska, Beata Wielgus-Kutrowska   +3 more
doaj   +1 more source

Oligomeric Symmetry of Purine Nucleoside Phosphorylases

Symmetry
Many enzymes are composed of several identical subunits, which are arranged in a regular fashion and usually comply with some definite symmetry. This symmetry may be approximate or exact and may or may not coincide with the symmetry of crystallographic packing.
Boris Gomaz, Zoran Štefanić
openaire   +2 more sources

Enzymatic Synthesis of Highly Fluorescent 8-Azapurine Ribosides Using a Purine Nucleoside Phosphorylase Reverse Reaction: Variable Ribosylation Sites

Molecules, 2013
Various forms of purine-nucleoside phosphorylase (PNP) were used as catalysts of enzymatic ribosylation of selected fluorescent 8-azapurines. It was found that the recombinant calf PNP catalyzes ribosylation of 2,6-diamino-8-azapurine in a phosphate-free
Goran Mikleušević, Alicja Stachelska-Wierzchowska, Beata Wielgus-Kutrowska, Jacek Wierzchowski   +3 more
doaj   +1 more source

Supplementary Data from Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer

, 2023
Shahraam Afshar V., Tsuneaki Asai, Sherie L. Morrison   +2 more
openalex   +1 more source

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Pharmaceutical and Biomedical Research, 2019
Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash   +9 more
doaj  

Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. [PDF]

Arch Iran Med, 2023
Alizadeh Z, Badalzadeh M, Heydarlou H, Shakerian L, Mahlooji Rad M, Zandieh F, Fazlollahi MR.   +6 more
europepmc   +1 more source