Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology [PDF]
, 2019 Adenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal ...
Albasanz, José Luis +3 more
core +1 more source
Immunodeficiency and autoimmunity: companions not opposites
The Journal of Clinical Investigation, 2022 Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune ...
David A. Fox
doaj +1 more source
Time-Resolved Emission Study of a Thiophene-Modified Fluorescent Nucleoside in Solution and within Multiply-Modified Oligodeoxynucleotides [PDF]
arXiv, 2014 Steady-state and time-resolved emission techniques were employed to study the photophysical properties of 5-(thien-2-yl)-2'-deoxyuridine (dUTh), an isomorphic fluorescent nucleoside analog. We found that the emission lifetime of dUTh is dependent upon the solvent viscosity and obeys the F\"orster-Hoffman relation over a wide range of temperatures in 1 ...
arxiv
The role of adenine nucleotides and their derivatives in the control of liver metabolism [PDF]
, 1980 Imperial Users ...
Sharma, Ravi Janak, Sharma, Ravi Janak
core
Nucleotide degradation and ribose salvage in yeast
Molecular Systems Biology, 2013 Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway.
Yi‐Fan Xu +9 more
doaj +1 more source
Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states [PDF]
, 2009 To represent the evolution of nucleic acid and protein sequence, we express the parallel and Eigen models for molecular evolution in terms of a functional integral representation with an $h$-letter alphabet, lifting the two-state, purine/pyrimidine assumption often made in quasi-species theory. For arbitrary $h$ and a general mutation scheme, we obtain
arxiv +1 more source
Aeromonas hydrophila strains as biocatalysts for transglycosylation [PDF]
, 2010 Microbial transglycosylation is useful as a green alternative in the preparation of purine nucleosides and analogues, especially for those that display pharmacological activities.
Iribarren, Adolfo Marcelo +3 more
core +1 more source
Molecules, 2013 Various forms of purine-nucleoside phosphorylase (PNP) were used as catalysts of enzymatic ribosylation of selected fluorescent 8-azapurines. It was found that the recombinant calf PNP catalyzes ribosylation of 2,6-diamino-8-azapurine in a phosphate-free
Goran Mikleušević +3 more
doaj +1 more source
Nitrogen Substituted Polycyclic Aromatic Hydrocarbon As Capable Interstellar Infrared Spectrum Source Considering Astronomical Chemical Evolution Step To Biological Organic Purine And Adenine [PDF]
arXiv, 2016 In order to find out capable chemical evolution step from astronomically created organic in interstellar space to biological organic on the earth, infrared spectrum of nitrogen substituted carbon pentagon-hexagon coupled polycyclic aromatic hydrocarbon was analyzed by the density functional theory.
arxiv
An Efficient Chemoenzymatic Process for Preparation of Ribavirin
International Journal of Chemical Engineering, 2015 Ribavirin is an important antiviral drug, which is used for treatment of many diseases. The pilot-scale chemoenzymatic process for synthesis of the active pharmaceutical ingredient Ribavirin was developed with 32% overall yield and more than 99.5% purity.
Vladimir Sakharov +4 more
doaj +1 more source