Results 101 to 110 of about 25,575 (276)

Circulating Human Neonatal Naïve B cells are Deficient in CD73 Impairing Purine Salvage

Frontiers in Immunology, 2016
Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate (ATP), are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function
Matthew Aaron Pettengill, Ofer eLevy, Ofer eLevy   +2 more
doaj   +1 more source

Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. [PDF]

PLoS ONE, 2011
Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confounded
Shaiju K Vareed, Vadiraja B Bhat, Christopher Thompson, Vihas T Vasu, Damian Fermin, Hyungwon Choi, Chad J Creighton, Sitaram Gayatri, Ling Lan, Nagireddy Putluri, Gagan Singh Thangjam, Punit Kaur, Mohsen Shabahang, Judith G Giri, Alexey I Nesvizhskii, Alexander A A Asea, Anil G Cashikar, Arundhati Rao, James McLoughlin, Arun Sreekumar   +19 more
doaj   +1 more source

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

The antiepileptic potential of nucleosides [PDF]

, 2014
Despite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately one third of patients remain drug refractory. Consequently, there is an urgent need to develop more effective therapeutic approaches to treat epilepsy. A great deal
Dobolyi, Á., Juhász, G., Kovács, Z., Kékesi, K .A.   +3 more
core   +1 more source

Human adenovirus serotype 5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts

The FASEB Journal, Volume 39, Issue 5, 15 March 2025.
Human adenovirus serotype 5 was used to infect HEK293 fibroblasts at low MOI (0.5, 1.0, and 2.0). Infected cells were interrogated by gas chromatography time‐of‐flight mass spectrometry (GC‐TOF‐MS) at 6, 12, 24, and 36 h post‐infection. The total metabolites were evaluated using an untargeted analysis of primary carbons. The results indicate a decrease
Bailey‐J C. Sanchez, Rudy M. Ortiz, Juris A. Grasis   +2 more
wiley   +1 more source

Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency

Egyptian Journal of Medical Human Genetics
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb, Sohilla Lotfy, Rabab E. El Hawary, Safa S. Meshaal, Iman A. Mansour, Nermeen M. Galal, Aisha M. Elmarsafy   +6 more
doaj   +1 more source

Proteomic alterations of Escherichia coli by paraquat [PDF]

, 2010
Paraquat (PQ; a widely used herbicide) exerts its harmful effect to human, mammals and microorganisms upon intracellular conversion to superoxide radical.
Isarankura-Na-Ayudhya, Chartchalerm, Isarankura-Na-Ayudhya, Patcharee, Polprachum, Wilaiwan, Prachayasittikul, Virapong, Roytrakul, Sittiruk, Singhagamol, Watsarach, Thippakorn, Chadinee, Yainoy, Sakda   +7 more
core  

Purine nucleoside phosphorylase in chronic lymphocytic leukemia (CLL) [PDF]

Blood, 1978
Purine nucleoside phosphorylase (PNP), the enzyme schematically next to adenosine deaminase in the purine salvage pathway, has been demonstrated cytochemically in peripheral blood lymphocytes of healthy subjects and chronic lymphocytic leukemia (CLL) patients. The enzyme activity is confined to the cytosol.
J. De Cree, M. Borgers, W. De Cock, M. De Brabander, Herman Verhaegen, G. Geuens, Fred Thoné   +6 more
openaire   +4 more sources

Abiotic Ribonucleoside Formation in Aqueous Microdroplets: Mechanistic Exploration, Acidity, and Electric Field Effects

ChemistryEurope, Volume 3, Issue 2, March 10, 2025.
A computational investigation of the reported abiotic phosphorylation of ribose and the subsequent formation of ribonucleosides reveals that the most plausible reaction mechanism involves the protonation of ribose, followed by carbocation formation and an SN2 substitution step.
Maciej Piejko, Javier E. Alfonso‐Ramos, Joseph Moran, Thijs Stuyver   +3 more
wiley   +1 more source

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties.

PLoS ONE, 2018
Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related to pharmacological potential.
Jefferson A Rocha, Nayra C S Rego, Bruna T S Carvalho, Francisco I Silva, Jose A Sousa, Ricardo M Ramos, Ionara N G Passos, Josué de Moraes, Jose R S A Leite, Francisco C A Lima   +9 more
doaj   +1 more source