Results 101 to 110 of about 25,696 (291)

Rapid and chemically diverse C transfer from trees to mycorrhizal fruit bodies in the forest

Functional Ecology, Volume 39, Issue 6, Page 1343-1357, June 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ectomycorrhizal fungi (EMF) are common belowground tree symbionts, supplying trees with water and nutrients. In return, large amounts of C assimilated by trees can be allocated into EMF. However, the chemical forms in which the C is transferred from trees to fungi under
Alon Rapaport, Stav Livne‐Luzon, Hagar Fox, Yaara Oppenheimer‐Shaanan, Tamir Klein   +4 more
wiley   +1 more source

Purine nucleoside phosphorylase in chronic lymphocytic leukemia (CLL) [PDF]

Blood, 1978
Purine nucleoside phosphorylase (PNP), the enzyme schematically next to adenosine deaminase in the purine salvage pathway, has been demonstrated cytochemically in peripheral blood lymphocytes of healthy subjects and chronic lymphocytic leukemia (CLL) patients. The enzyme activity is confined to the cytosol.
J. De Cree, M. Borgers, W. De Cock, M. De Brabander, Herman Verhaegen, G. Geuens, Fred Thoné   +6 more
openaire   +4 more sources

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, Volume 97, Issue 5, Page 809-825, May 2025.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source

Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency

Egyptian Journal of Medical Human Genetics
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb, Sohilla Lotfy, Rabab E. El Hawary, Safa S. Meshaal, Iman A. Mansour, Nermeen M. Galal, Aisha M. Elmarsafy   +6 more
doaj   +1 more source

Circulating Human Neonatal Naïve B cells are Deficient in CD73 Impairing Purine Salvage

Frontiers in Immunology, 2016
Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate (ATP), are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function
Matthew Aaron Pettengill, Ofer eLevy, Ofer eLevy   +2 more
doaj   +1 more source

Targeted enzyme prodrug therapy for metastatic prostate cancer – a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase

Journal of Biomedical Sciences, 2014
BackgroundEnzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion proteins targeted via annexin V to ...
Katrin P. Guillen, C. Kurkjian, R. Harrison   +2 more
semanticscholar   +1 more source

Novel Approach to Overcome Osimertinib Resistance Using Bromodomain and Extra‐Terminal Domain Inhibitors

Cancer Science, Volume 116, Issue 5, Page 1392-1404, May 2025.
Our study found that epigenetic changes, particularly histone modifications regulating FGF1, contribute to osimertinib resistance. Targeting these modifications with BET inhibitors may offer new therapeutic strategies. ABSTRACT Osimertinib, a third‐generation EGFR‐tyrosine kinase inhibitor, is the first‐line therapy for lung cancer harboring EGFR ...
Yosuke Miyashita, Ken Tajima, Kenta Izumi, Naohisa Matsumoto, Daisuke Hayakawa, Ikuko Takeda Nakamura, Isana Katayama, Adityo Wibowo, Hironari Matsuda, Wira Winardi, Bagus Radityo Amien, Yoichiro Mitsuishi, Fumiyuki Takahashi, Kohta Nakamura, Ken Uchibori, Noriko Yanagitani, Takuo Hayashi, Kazuya Takamochi, Kenji Suzuki, Ryohei Katayama, Kazuhisa Takahashi   +20 more
wiley   +1 more source

Myocardial release of hypoxanthine and lactate during percutaneous transluminal coronary angioplasty [PDF]

, 1989
The response of myocardial lactate and hypoxanthine metabolism during percutaneous transluminal coronary angioplasty was studied in a series of 15 patients undergoing this procedure.
Brand, M.J.B.M. (Marcel) van den, Feyter, P.J. (Pim) de, Harmsen, E., Hugenholtz, P.G. (Paul), Jong, J.W. (Jan Willem) de, Piscione, F., Serruys, P.W.J.C. (Patrick), Suryapranata, H. (Harry)   +7 more
core   +1 more source

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman, Alexandra Emerson, Peter M. Wilson, Karl A. Mulligan, Robert D. Ladner, Melissa J. LaBonte   +5 more
wiley   +1 more source

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Eukaryotic Cell, 2014
The intracellular pathogen Toxoplasma gondii is a purine auxotroph that relies on purine salvage for proliferation. We have optimized T. gondii purine nucleoside phosphorylase (TgPNP) stability and crystallized TgPNP with phosphate and immucillin-H, a ...
T. Donaldson, M. Cassera, M. Ho, C. Zhan, E. Merino, G. Evans, P. Tyler, S. Almo, V. Schramm, Kami Kim   +9 more
semanticscholar   +1 more source