Results 81 to 90 of about 19,457 (231)

Purine Molecular Interactions Determine Anisotropic Shape of Zebrafish Biogenic Crystals

Small Methods, Volume 9, Issue 9, September 1, 2025.
Many organisms self‐organize crystals for vision, pigmentation, or storage. In zebrafish, iridophores produce anisotropic crystals in iridosomes. Using imaging and genetic tools, crystal growth is shown to favor the b‐axis, shaped by guanine‐to‐hypoxanthine ratios and hydrogen bonding resulting thereof.
Jannik Rothkegel, Sylvia Kaufmann, Michaela Wilsch‐Bräuninger, Catarina Lopes, Rita Mateus   +4 more
wiley   +1 more source

Circulating Human Neonatal Naïve B cells are Deficient in CD73 Impairing Purine Salvage

Frontiers in Immunology, 2016
Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate (ATP), are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function
Matthew Aaron Pettengill, Ofer eLevy, Ofer eLevy   +2 more
doaj   +1 more source

Role of Toll‐Like Receptors in Myeloid Neoplasms: Focuses on the Molecular Mechanisms and Clinical Impact on Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myeloid Leukemia

APMIS, Volume 133, Issue 9, September 2025.
ABSTRACT Toll‐like receptors (TLRs) are essential components of the innate immune system, functioning as pattern recognition receptors (PRRs) to detect pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs). In hematological malignancies, particularly myelodysplastic syndromes (MDS), acute myeloid leukemia (AML),
Clarissa Brenda Alves Cavalcante, Alessandro Cavalcante Chaves, Vanessa Silva de Oliveira, Maria Amanda Silva de Araújo, Thayres Marinho Cunha e Silva, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro‐Junior   +8 more
wiley   +1 more source

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties.

PLoS ONE, 2018
Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related to pharmacological potential.
Jefferson A Rocha, Nayra C S Rego, Bruna T S Carvalho, Francisco I Silva, Jose A Sousa, Ricardo M Ramos, Ionara N G Passos, Josué de Moraes, Jose R S A Leite, Francisco C A Lima   +9 more
doaj   +1 more source

Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism

npj Science of Food
Reducing intestinal absorption by degrading purine nucleosides has been shown to alleviate hyperuricemia (HUA). The probiotic Pediococcus acidilactici GR-5, derived from the traditional food “Jiangshui”, achieved efficient degradation of purine ...
Jing Ji, Zi-Yi An, Aman Khan, Liang Peng, Sourabh Kulshreshtha, El-Sayed Salama, Hui Yun, Pu Liu, Wei-Lin Jin, Xiangkai Li   +9 more
doaj   +1 more source

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients

Annals of Saudi Medicine, 2009
Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive metabolic disorder that results in combined immunodeficiency, neurologic dysfunction and autoimmunity.
Alangari Abdullah, Al-Harbi Abdullah, Al-Ghonaium Abdulaziz, Santisteban Ines, Hershfield Michael   +4 more
doaj  

Targeted enzyme prodrug therapy for metastatic prostate cancer – a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase

Journal of Biomedical Sciences, 2014
BackgroundEnzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion proteins targeted via annexin V to ...
Katrin P. Guillen, C. Kurkjian, R. Harrison   +2 more
semanticscholar   +1 more source

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Eukaryotic Cell, 2014
The intracellular pathogen Toxoplasma gondii is a purine auxotroph that relies on purine salvage for proliferation. We have optimized T. gondii purine nucleoside phosphorylase (TgPNP) stability and crystallized TgPNP with phosphate and immucillin-H, a ...
T. Donaldson, M. Cassera, M. Ho, C. Zhan, E. Merino, G. Evans, P. Tyler, S. Almo, V. Schramm, Kami Kim   +9 more
semanticscholar   +1 more source

Correction: Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors [PDF]

, 1992
S. E. Ealick
openalex   +1 more source

Effects of Different Packaging on the Purine Content and Key Enzymes of Refrigerated Yellow Croaker (Larimichthys crocea)

Foods
In this study, we investigated the effects of air packaging, vacuum packaging and modified atmosphere packaging (CO2/N2: 80/20) on the purine metabolism and enzyme activities of refrigerated large yellow croakers.
Tiansheng Xu, Wenxuan Lu, Bohan Chen, Dapeng Li, Jing Xie   +4 more
doaj   +1 more source