Results 81 to 90 of about 25,575 (276)

Sexual Selection on Non‐Ornamental Traits Is Underpinned by Evidence of Genetic Constraints on Sex‐Biased Expression in Dusky Pipefish

Molecular Ecology, EarlyView.
ABSTRACT Species lacking distinct secondary sex characteristics, such as differences in size or morphology, are often thought to experience lower levels of sex‐specific selection in comparison to highly sexually dimorphic organisms. However, monomorphism in classic visible traits could be a result of genetic or physiological constraints that prevent ...
Nicole M. Tosto, Emily Rose, Heather D. Mason, Judith E. Mank, Sarah P. Flanagan   +4 more
wiley   +1 more source

Inhibition of free radical generation and improved survival by protection of the hepatic microvascular endothelium by targeted erythrocytes in orthotopic rat liver transplantation [PDF]

, 1990
The capacity of specifically targeted erythrocytes to inhibit free radical—mediated injury to the endothelial cell after cold preservation, and improve liver function was studied in two experimental models: An isolated perfused rat liver (IPRL) system ...
Demetris, AJ, Liu, T, Makowka, L, Mischinger, HJ, Rao, PN, Rubin, RS, Snyder, JT, Starzl, TE, Walsh, TR   +8 more
core   +1 more source

Engineering Substrate Promiscuity of Nucleoside Phosphorylase Via an Insertions–Deletions Strategy

JACS Au
Nucleoside phosphorylases (NPs) are the key enzymes in the nucleoside metabolism pathway and are widely employed for the synthesis of nucleoside analogs, which are difficult to access via conventional synthetic methods.
Gaofei Liu, Jialing Wang, Jianlin Chu, Tianyue Jiang, Song Qin, Zhen Gao, Bingfang He   +6 more
semanticscholar   +1 more source

The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning

Nature Communications, 2015
The study of biomolecular interactions between a drug and its biological target is of paramount importance for the design of novel bioactive compounds.
S. Decherchi, Anna Berteotti, G. Bottegoni, W. Rocchia, A. Cavalli   +4 more
semanticscholar   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, Volume 15, Issue 7, Page 1090-1102, July 2025.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Descriptor-and fragment-based QSAR models for a series of Schistosoma mansoni purine nucleoside inhibitors [PDF]

, 2011
The enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the treatment of major parasitic infectious diseases, with special emphasis on its role in the discovery of new drugs against ...
ANDRICOPULO, Adriano Defini, CASTILHO, Marcelo S, FREITAS, Humberto F, POSTIGO, Matheus P   +3 more
core   +1 more source

Tri-Cyclic Nucleobase Analogs and Their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives

Molecules, 2019
Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Beata Wielgus-Kutrowska   +4 more
doaj   +1 more source

Rapid and chemically diverse C transfer from trees to mycorrhizal fruit bodies in the forest

Functional Ecology, Volume 39, Issue 6, Page 1343-1357, June 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ectomycorrhizal fungi (EMF) are common belowground tree symbionts, supplying trees with water and nutrients. In return, large amounts of C assimilated by trees can be allocated into EMF. However, the chemical forms in which the C is transferred from trees to fungi under
Alon Rapaport, Stav Livne‐Luzon, Hagar Fox, Yaara Oppenheimer‐Shaanan, Tamir Klein   +4 more
wiley   +1 more source

Polymorphisme de la purine nucléoside phosphorylase érythrocytaire bovine [PDF]

, 1984
La distribution de variants électrophorétiques de la purine nucléoside phosphorylase (N.P.) contrôlée par deux allèles NP.H et NP.L a été étudiée sur des hémolysats bovins appartenant à des populations autochtones de zébus ou de taurins (race Baoulé) et ...
Bambara, L., Quéval, Rémy
core  

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, Volume 97, Issue 5, Page 809-825, May 2025.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source