Results 81 to 90 of about 25,696 (291)
Engineering Substrate Promiscuity of Nucleoside Phosphorylase Via an Insertions–Deletions Strategy
JACS AuNucleoside phosphorylases (NPs) are the key enzymes in the nucleoside metabolism pathway and are widely employed for the synthesis of nucleoside analogs, which are difficult to access via conventional synthetic methods.
Gaofei Liu +6 more
semanticscholar +1 more source
Nature Communications, 2015 The study of biomolecular interactions between a drug and its biological target is of paramount importance for the design of novel bioactive compounds.
S. Decherchi +4 more
semanticscholar +1 more source
Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper
Ecology and Evolution, Volume 15, Issue 9, September 2025.Introduced pathogens exert novel selection on hosts, and some hosts have adapted to highly virulent pathogens. We tested for differential gene expression between (i) avian malaria‐infected and ‐uninfected Hawai'i 'amakihi and (ii) low‐ and high‐elevation 'amakihi.
Loren Cassin‐Sackett +4 more
wiley +1 more source
Descriptor-and fragment-based QSAR models for a series of Schistosoma mansoni purine nucleoside inhibitors [PDF]
, 2011 The enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the treatment of major parasitic infectious diseases, with special emphasis on its role in the discovery of new drugs against ...
ANDRICOPULO, Adriano Defini +3 more
core +1 more source
Food Science &Nutrition, Volume 13, Issue 8, August 2025.The peeled Pinellia ternata (Thunb.) Breit tubers were dried with the microwave vacuum drying oven. Then, its drying characteristics, contents of nucleosides, and surface microstructural alterations of dried samples were determined, respectively. Drying parameters were predicted and optimized using four different mathematical models and artificial ...
Pan Wang +10 more
wiley +1 more source
A UV/Vis Spectroscopy-Based Assay for Monitoring of Transformations Between Nucleosides and Nucleobases [PDF]
, 2019 Efficient reaction monitoring is crucial for data acquisition in kinetic and mechanistic studies. However, for conversions of nucleosides to their corresponding nucleobases, as observed in enzymatically catalyzed nucleoside phosphorylation reactions, the
Giessmann, Robert T. +5 more
core +1 more source
Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection
Journal of Medical Virology, Volume 97, Issue 8, August 2025.ABSTRACT Nucleotides are the building blocks of DNA and RNA. They also play essential roles in various other biological processes, including protein glycosylation, ribosome biogenesis, and cytoskeletal function. The significance of the regulation of nucleotide metabolism has recently gained more attention in many physiological and pathological contexts,
Lara Dsouza, Zhilong Yang
wiley +1 more source
Nucleoside-dependent synthesis of organic phosphorus compounds by rat liver nuclei [PDF]
, 1967 a) A modified procedure of the WIDNELL and TATA8 method yields rat liver nuclei manifesting a high degree of purity and activity. b) These nuclei contain a nucleoside-dependent phosphorylating activity that is readily released and apparently unrelated to
Utsumi, Kozo
core +1 more source
Molecular Ecology, Volume 34, Issue 15, August 2025.ABSTRACT Species lacking distinct secondary sex characteristics, such as differences in size or morphology, are often thought to experience lower levels of sex‐specific selection in comparison to highly sexually dimorphic organisms. However, monomorphism in classic visible traits could be a result of genetic or physiological constraints that prevent ...
Nicole M. Tosto +4 more
wiley +1 more source
Proteomic alterations of Escherichia coli by paraquat [PDF]
, 2010 Paraquat (PQ; a widely used herbicide) exerts its harmful effect to human, mammals and microorganisms upon intracellular conversion to superoxide radical.
Isarankura-Na-Ayudhya, Chartchalerm +7 more
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