Results 181 to 190 of about 77,707 (283)

Structure of an initiation complex of mycobacterial helicase-nuclease AdnAB at a blunt double-strand break reveals local melting that engages the 3' tracking strand at the ratchet pawl of the helicase motor. [PDF]

Nucleic Acids Res
Warren GM, Jason de la Cruz M, Goldgur Y, Shuman S.   +3 more
europepmc   +1 more source

Acetyl‐Phosphate Dependent Protein Acetylation in Neisseria gonorrhoeae

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The role of acetyl‐phosphate‐dependent non‐enzymatic protein acetylation in Neisseria gonorrhoeae was investigated through the deletion of the phosphotransacetylase (pta) and the acetate kinase (ackA) genes, this led to a decrease and increase in protein acetylation, respectively.
Ernesto F. D. Parga, Paige A. Wolverson, Mark O. Collins, Oliver Heaney, Joby Cole, Luke R. Green, Jonathan G. Shaw   +6 more
wiley   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau, Nicoletta Luxi, Fabio Riefolo, Martín Solorzano, Irene Pazos, Elena Ballarín, Lise Skovgaard Svingel, Lorenzo Chiusaroli, Elisa Martín‐Merino, Elisa Barbieri, María Lopez‐Lasanta, Sima Mohammadi, Denis Rotta, Alexandra Pacurariu, Catherine Cohet, Miriam Sturkenboom, Carlos E. Durán, on behalf of the SAFETY‐VAC study consortium, Carlos E. Durán, Miriam Sturkenboom, Judit Riera‐Arnau, Nicoletta Luxi, Olaf Klungel, Patrick Souverein, Sima Mohammadi, Fabio Riefolo, Irene Pazos, Rosa Gini, Davide Messina, Giuseppe Roberto, Carlo Giaquinto, Elisa Barbieri, Luca Stona, Felipe Villalobos, Martín Solorzano, Carlo Alberto Bissacco, Antonio Gimeno, Beatriz Poblador, Mercedes Aza, Aida Moreno, Alejandro Santos, Vera Ehrenstein, Lise Skovgaard Svingel, Benjamin Randeris Johannesen, Cécile Droz‐Perroteau, Laure Carcaillon‐Bentata, Anna‐Mija Tolppanen, Sirpa Hartikainen, Thuan Vo, Anne Paakinaho, Blair Rajamaki, Hedvig Nordeng, Saeed Hayati, Mahmoud Zidan, Juan José Carreras Martínez, Arantxa Urchueguía Fornes, Elisa Correcher Martínez, Javier Díez‐Domingo, Mar Martin, Patricia Garcia‐Poza, Airam de Burgos, Belén Castillo‐Cano, Elisa Martín‐Merino   +62 more
wiley   +1 more source

Asymmetry of nucleotide substitutions in tRNAs indicates common descent of modern organisms from a thermophilic ancestor. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Titov II.
europepmc   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Untargeted Metabolomics Investigating the Intracellular Metabolic Alterations of HaCaT Cells Treated with Isotretinoin. [PDF]

Drug Des Devel Ther
Zhu S, He Y, Wu L, Ouyang X, Wei Q, Ye F, Li C.   +6 more
europepmc   +1 more source

Loss of Kv8.2 in the Mouse Retina Is Associated With Altered One‐Carbon Metabolism

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Kv8.2 knockout mice, a model of KCNV2 retinopathy, exhibit impaired potassium homeostasis in photoreceptors and slowly progressive rod degeneration. To investigate metabolic adaptations accompanying this dysfunction, untargeted metabolomic profiling was performed on mouse retinas.
Karina Kruth, Sheila A. Baker
wiley   +1 more source

Global response to antibiotic exposure reveals a critical role for nucleotide metabolism in high-level β-lactam tolerance. [PDF]

NPJ Antimicrob Resist
Keller MR, Kazi MI, Saleh A, Basu U, Shin JH, Rhee K, Dörr T.   +6 more
europepmc   +1 more source

Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background & Aims Hepatoblastoma (HB) is the most common malignant liver tumour in children. Despite improved survival in low‐risk disease, outcomes for advanced or relapsed HB remain poor, emphasising the need for new therapeutic targets.
Luz A. Martínez‐Pérez, M. Ujue Latasa, Iker Uriarte, Amaya López‐Pascual, Jasmin Elurbide, Pavel Strnad, Sona Frankova, Eva Sticova, Ondrej Fabian, Maria Arechederra, Eva Santamaria, Josepmaria Argemi, Bruno Sangro, Beatrice Foglia, Maurizio Parola, Melva Gutiérrez‐Angulo, Stefano Cairo, Ramón Bataller, Pau Sancho‐Bru, Maria L. Martinez‐Chantar, Jose J. G. Marin, Andrea Castaneda, Carolina Armengol, Carmen Berasain, Maite G. Fernandez‐Barrena, Matias A. Ávila   +25 more
wiley   +1 more source

Implication of xanthine oxidoreductase in oxidative stress-related chronic diseases. [PDF]

Front Endocrinol (Lausanne)
Nelson KL, Voruganti VS.
europepmc   +1 more source