Results 191 to 200 of about 76,319 (326)

Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.

, 1976
Chhabirani Mukherjee, Robert J. Lefkowitz   +1 more
openalex   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

The Purine Nucleotide Cycle

, 1974
Keith Tornheim, John M. Lowenstein
openalex   +1 more source

92 REDUCED PURINE NUCLEOTIDE CONTENT AND POLY(ADP-RIBOSE) SYNTHETASE ACTIVITY IN HPRT-DEFICIENT HUMAN LYMPHOBLASTS [PDF]

, 1988
G. M. McCreanor
openalex   +1 more source

PURINE INCORPORATION INTO PENTOSE NUCLEOTIDES OF THE RAT

Journal of Biological Chemistry, 1951
George Bosworth Brown, Denis H. Marrian, V.L. Spicer, M.E. Balis   +3 more
openaire   +3 more sources

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, Volume 12, Issue 33, September 4, 2025.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology. [PDF]

J Clin Invest
Kager L, Boztug K.
europepmc   +1 more source

PURINE NUCLEOTIDE AND DEOXYNUCLEOTIDE CATABOLISM IN HUMAN T LYMPHOCYTES: 36 [PDF]

, 1985
Amos Cohen, Jerzy Barankiewicz
openalex   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, Volume 12, Issue 34, September 11, 2025.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

66 PURINE NUCLEOTIDE SUPPLY OF THE HUMAN TROPHOBLAST [PDF]

, 1988
Kim Vettenranta, Kari O. Raivio
openalex   +1 more source