Results 211 to 220 of about 76,319 (326)

Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease

open access: yesBrain and Behavior, Volume 15, Issue 9, September 2025.
This Mendelian randomization study systematically screened 338 cerebrospinal fluid metabolites and identified several with potential causal effects on Parkinson's disease, offering new insights into disease pathogenesis. ABSTRACT Background Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by motor impairments and ...
Houwen Zhang   +5 more
wiley   +1 more source

The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity. [PDF]

open access: yesJ Clin Invest
Maillard M   +11 more
europepmc   +1 more source

Purine Nucleotide Phosphorylase deficiency

open access: yesPediatric Hematology Oncology Journal
Anirudh Mahajan, Kritika, Vikas
openaire   +2 more sources

THE CATABOLISM OF THE PURINE NUCLEOTIDES [PDF]

open access: yesJournal of Biological Chemistry, 1938
Frank Worthington Allen, John J. Eiler
openaire   +1 more source

ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk

open access: yesBrain and Behavior, Volume 15, Issue 9, September 2025.
Mendelian randomization identifies palmitoylation genes driving generalized anxiety disorder (GAD) risk, notably ZDHHC5 and ZDHHC13. ZDHHC5 promotes GAD pathogenesis by modulating SSC‐A on CD4+ T cells, revealing novel immune‐mediated mechanisms and therapeutic targets for GAD.
Fuqiang Sun   +8 more
wiley   +1 more source

The impact of bacterial purine metabolism on antibiotic efficacy. [PDF]

open access: yesNPJ Antimicrob Resist
Stevens CE, Deventer AT, Hobbs JK.
europepmc   +1 more source

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