Results 221 to 230 of about 76,319 (326)

A novel molecular switch in plant growth: how adenosine kinase activity modulates plant development and growth pathways. [PDF]

J Exp Bot
Watson KM.
europepmc   +1 more source

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism [PDF]

Cancer Med
ABSTRACT Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current literature on the metabolic adaptation of cancer cells was carried out in the current study. Results The rapidly
Punnasseril J, Auwal A, Gopalan V, Lam A, Islam F.   +4 more
europepmc   +2 more sources

Structure-activity relationship of purine and pyrimidine derivatives on cyclic nucleotide phosphodiesterase activity of rat brain

, 1979
Matsutaro Murakami, Shiro Torninaga, Katsuhiro Watanabe, Hikaru Ozawa   +3 more
openalex   +1 more source

Analysis of the Chicken GPAT/AIRC Bidirectional Promoter for de Novo Purine Nucleotide Synthesis [PDF]

, 1995
Anthony Gavalas, H Zalkin
openalex   +1 more source

Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Min Su, Huan Qin, Jie Shen, Hao An, Yu Cao   +4 more
wiley   +1 more source

Regulatory helix plays a key role in genetic ON-OFF switching for the 2'-deoxyguanosine-sensing mRNA element. [PDF]

J Biol Chem
Chaudhury SN, Jespersen NE, Hennelly SP, Sanbonmatsu KY.   +3 more
europepmc   +1 more source

Mutation in the phosphoribosylpyrophosphate synthetase gene (prs) that results in simultaneous requirements for purine and pyrimidine nucleosides, nicotinamide nucleotide, histidine, and tryptophan in Escherichia coli

, 1988
Bjarne Hove‐Jensen
openalex   +1 more source

Characterization of P2 receptors for purine and pyrimidine nucleotides in human placental cotyledons [PDF]

, 1997
Vera Ralevic, Stephen Burrell, John‏ Kingdom, Geoffrey Burnstock   +3 more
openalex   +1 more source

Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper

Ecology and Evolution, Volume 15, Issue 9, September 2025.
Introduced pathogens exert novel selection on hosts, and some hosts have adapted to highly virulent pathogens. We tested for differential gene expression between (i) avian malaria‐infected and ‐uninfected Hawai'i 'amakihi and (ii) low‐ and high‐elevation 'amakihi.
Loren Cassin‐Sackett, Katherine M. McClure, Taylor E. Callicrate, Eben H. Paxton, Robert C. Fleischer   +4 more
wiley   +1 more source

Unraveling unbreakable hairpins: characterizing RNA secondary structures that are persistent after dinucleotide shuffling. [PDF]

RNA
Pratt AA, Hendrix DA.
europepmc   +1 more source