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Purine Nucleotide Synthesis during Terminal Differentiation
1989A number of human myeloid leukemia cell lines have been established which can not only be maintained as immature blast cells in continuous, self-renewing culture but also be induced to undergo maturation toward either the myeloid or monocytic phenotype1).
H, Tsutani +5 more
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Purine Nucleotide Interconversions
1978The various reactions of purine ribonucleotide synthesis result in the formation of adenylate, inosinate, and guanylate; xanthylate may also be formed, but this seems to be a quantitatively minor process in most mammalian cells. These purine ribonucleoside monophosphates can be metabolized in several different ways; these processes can in general be ...
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Thermodynamics of the purine nucleotide cycle
Biophysical Chemistry, 2006Since the standard Gibbs energies of formation are known for all the species in the purine nucleotide cycle at 298.15 K, the functions of pH and ionic strength that yield the standard transformed Gibbs energies of formation of the ten reactants can be calculated.
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Advances in biochemical psychopharmacology, 1977
The existence of nonadrenergic, noncholinergic nerve components in the autonomic nervous system is now well established. They are strongly represented in the gastrointestinal tract of all vertebrates and have been identified in a variety of other organs, including lung, trachea, bladder, esophagus, eye, seminal vesicles, and possibly parts of the ...
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The existence of nonadrenergic, noncholinergic nerve components in the autonomic nervous system is now well established. They are strongly represented in the gastrointestinal tract of all vertebrates and have been identified in a variety of other organs, including lung, trachea, bladder, esophagus, eye, seminal vesicles, and possibly parts of the ...
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Degradation of Purine Nucleotides
1978Purine nucleotides have a vital role in metabolism. Therefore, the maintenance of a constant nucleotide composition of the cell is essential for normal function. Purine nucleotides are synthesized by purine biosynthesis de novo, by salvage pathways and nucleoside kinases, and by degradation of nucleic acids.
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Purine Nucleotide Restoration in HPRT- Cells
1989Lesch-Nyhan syndrome is caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) (1, 2). This enzyme catalyzes the conversion of the purine bases hypoxanthine and guanine to their respective 5′ribo-nucleotides. It is reasonable to assume that a deficiency of HPRT would cause a decrease in the cellular concentrations of
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Purine Nucleotide Imbalance in Immunodeficiency Disorders
1985In 1972, Dr Hilaire Meuwissen of Albany, New York, sent some blood samples to Eloise Giblett of the Puget Sound Blood Center, Seattle, Washington, for analysis of genetic markers. One of the blood samples was from a patient with severe combined immunodeficiency disease and the other samples were from the patient’s parents Dr.
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The Purine Nucleotide Cycle Revised
International Journal of Sports Medicine, 1990This review is restricted to the operation of the purine cycle in mammalian muscle. A previous review provided a summary of early evidence for the operation of the cycle and of various functions proposed for the cycle. It also provided a brief history of work on ammonia production by muscle and other tissues and of the discovery of the enzymes of the ...
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Pyridine Nucleotide Metabolism: Purine and Pyrimidine Interconnections
1991The role of the pyridine coenzymes NAD and NADP in oxidation-reduction reactions, leading to energy production and to reductive synthesis, is well documented, and the characteristics of the proteins involved have been extensively studied. Since the balance between the oxidised and reduced form of pyridine coenzymes modulates both catabolic and ...
V, Micheli +5 more
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Nucleotide, Nucleoside, Purine, Pyrimidine, Pteridine
1952Die Organe erwachsener Tiere enthalten zumeist mehr Ribonucleotide als Desoxyribonucleotide (Tabelle 159). Der Quotient RN : DRN ist in fetalen Geweben kleiner als in erwachsenen. J. Geschwind und C. H. Li fanden ihn in der fetalen Rattenleber zu 0,9, in der Leber neugeborener Ratten zu 1,9 und in der Leber 40 Tage alter Ratten zu 2,8.
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