Results 31 to 40 of about 76,319 (326)

Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich

BMC Genomics, 2005
Background Eukaryotic organisms contain mitochondria, organelles capable of producing large amounts of ATP by oxidative phosphorylation. Each cell contains many mitochondria with many copies of mitochondrial DNA in each organelle.
Samuels David C, Rathi Anand, Bradshaw Patrick C   +2 more
doaj   +1 more source

De novo nucleotide biosynthetic pathway and cancer

Genes and Diseases, 2023
De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation.
Jie Chen, Siqi Yang, Yingge Li, Xu Ziwen, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei   +7 more
doaj   +1 more source

Purine metabolism in the light of aerobic and anaerobic capacity of female boxers

Central European Journal of Sport Sciences and Medicine, 2020
The aim of the work was to assess the intensity of purine nucleotide degradation during maximum physical exercise. 5 elite female boxers were the subject of the study.
Katarzyna Domaszewska, Piotr Szewczyk, Jakub Kryściak, Edyta Michalak, Tomasz Podgórski   +4 more
doaj   +1 more source

An Intermediary Role of Adenine Nucleotides on Free Fatty Acids-Induced Hyperglycemia in Obese Mice

Frontiers in Endocrinology, 2019
Increased plasma free fatty acids (FFA) level plays a central role in the development of type 2 diabetes. Our previous studies have shown that plasma 5′-adenosine monophosphate (5′-AMP) elevates and acts as a potential upstream regulator of hyperglycemia
Xiao Yang, Yang Zhao, Qi Sun, Yunxia Yang, Yan Gao, Wenhao Ge, Junhao Liu, Xi Xu, Jianfa Zhang   +8 more
doaj   +1 more source

Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function

iScience, 2020
Summary: The intestinal mucosa requires high levels of nucleotides for energy procurement, proliferation, and innate immunity. This need for nucleotide substrates substantially increases during injury, infection, and wound healing. In the present studies,
J. Scott Lee, Ruth X. Wang, Matthew S. Goldberg, Garrett P. Clifford, Daniel J. Kao, Sean P. Colgan   +5 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases

Frontiers in Immunology, 2018
Ecto-nucleotidase activity is involved in the infection process of Leishmania and various other parasites that enables modulation of host immune responses to promote disease progression.
Nalu Teixeira de Aguiar Peres, Nalu Teixeira de Aguiar Peres, Luana Celina Seraphim Cunha, Meirielly Lima Almeida Barbosa, Márcio Bezerra Santos, Márcio Bezerra Santos, Fabrícia Alvise de Oliveira, Amélia Maria Ribeiro de Jesus, Amélia Maria Ribeiro de Jesus, Roque Pacheco de Almeida, Roque Pacheco de Almeida   +10 more
doaj   +1 more source

The Intersection of Purine and Mitochondrial Metabolism in Cancer

Cells, 2021
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto, Danushka B. Arachchige, Brian C. Richardson, Jarrod B. French   +3 more
doaj   +1 more source

Yeast to Study Human Purine Metabolism Diseases

Cells, 2019
Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
Bertrand Daignan-Fornier, Benoît Pinson
doaj   +1 more source