Results 101 to 110 of about 2,316,796 (350)

Exploration of Fluorinated Pyrazolidine‐3,5‐Diones for Positron Emission Tomography Imaging of the P2Y12 Receptor in the Central Nervous System

ChemMedChem, EarlyView.
Fluorinated pyrazolidine‐3,5‐dione derivatives are developed with the aim to find a positron emission tomography (PET) tracer candidate for imaging of the P2Y12 receptor. All compounds show nanomolar affinity. One compound is radiolabeled with 18F and used in PET imaging studies, revealing rapid metabolism and limited brain uptake.
E. Johanna L. Stéen, Anne van der Schatte Olivier, Berend van der Wildt, Pedro Pereira, Khaled Alkayal, Leopoldo J. Gabella Carena, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Barbara A. Zarzycka, Iwan J. P. de Esch, Albert D. Windhorst   +11 more
wiley   +1 more source

Purinergic receptors in neurogenic processes

Brain Research Bulletin, 2019
Neurogenesis is a process of generating functional neurons, which occurs during embryonic and adult stages in mammals. While neurogenesis during development phase is characterized by intensive proliferation activity in all regions of the brain to form the architecture and neural function of the nervous system, adult neurogenesis occurs with less ...
D.E. Ribeiro, T. Glaser, Á. Oliveira-Giacomelli, H. Ulrich   +3 more
openaire   +2 more sources

mGluR1 receptors contribute to non-purinergic slow excitatory transmission to submucosal VIP neurons of guinea-pig ileum

Frontiers in Neuroscience, 2009
Vasoactive intestinal peptide (VIP) immunoreactive secretomotor neurons in the submucous plexus are involved in mediating bacterial toxin-induced hypersecretion leading to diarrhoea.
Jaime Pei Pei Foong, Joel C Bornstein
doaj   +1 more source

Aspirin-dependent effects on purinergic P2Y1 receptor express [PDF]

, 2019
Chronic treatment with aspirin in healthy volunteers (HVs) is associated with recovery of adenosine diphosphate (ADP)-induced platelet activation. The purinergic P2Y1 receptor exerts its effects via a Gq-protein, which is the same biochemical pathway ...
Alemanno, Laura, Angiolillo, Dominick J, Ceccacci, Andrea, Frati, Luigi, Guarino, Maria Luisa, Guerriero, Raffaella, Mancone, Massimo, Massimi, Isabella, Pulcinelli, Fabio M   +8 more
core   +1 more source

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

PLoS ONE, 2014
Background and Purpose Recent evidence indicates an involvement of P2X7 purinergic receptor (P2X7R) in the fine tuning of immune functions, as well as in driving enteric neuron apoptosis under intestinal inflammation.
L. Antonioli, M. Giron, R. Colucci, C. Pellegrini, Deborah Sacco, V. Caputi, G. Orso, M. Tuccori, C. Scarpignato, C. Blandizzi, M. Fornai   +10 more
semanticscholar   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2014
Extracellular nucleotides via activation of P2 purinergic receptors influence hepatocyte proliferation and liver regeneration in response to 70% partial hepatectomy (PH).
Bryan C Tackett, Hongdan Sun, Y. Mei, J. Maynard, Sayuri Cheruvu, Arunmani Mani, A. Hernandez-Garcia, N. Vigneswaran, S. Karpen, S. Thevananther   +9 more
semanticscholar   +1 more source

A polycystin-type transient receptor potential (Trp) channel that is activated by ATP

Biology Open, 2017
ATP and ADP are ancient extra-cellular signalling molecules that in Dictyostelium amoebae cause rapid, transient increases in cytosolic calcium due to an influx through the plasma membrane.
David Traynor, Robert R. Kay
doaj   +1 more source

ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]

, 2009
Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Fadi AlDehni, Jiraporn Ousingsawat, Joana Almaç, Karl Kunzelmann, Rainer Schreiber, Ralph Witzgall, René   +6 more
core   +2 more sources

Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer.

Cancer Research, 2015
Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of ...
P. Hofman, Julien Cherfils-Vicini, Marie Bazin, M. Ilié, Thierry Juhel, X. Hébuterne, E. Gilson, A. Schmid-Alliana, O. Boyer, S. Adriouch, V. Vouret-Craviari   +10 more
semanticscholar   +1 more source