Results 101 to 110 of about 2,325,321 (255)

Decision letter: TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

, 2021
Mohamed Trebak
openalex   +1 more source

Generalised Hodgkin–Huxley model captures human P2X and AMPA receptor currents

The Journal of Physiology, EarlyView.
Abstract figure legend A universal, biophysically interpretable mathematical model for human ionotropic receptors. The generalised Hodgkin–Huxley (gHH) model unifies the mathematical description of all major ligand‐gated ionotropic receptors (P2X1–7, AMPA) across diverse cell types, capturing activation, inactivation, desensitisation and recovery ...
Alireza Poshtkohi, Brian D. Gulbransen
wiley   +1 more source

NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium

Neurobiology of Disease, 2010
In the CNS, ATP is released upon injury and promotes neuroproliferation via purinergic receptors. In the olfactory epithelium, ATP promotes the synthesis and release of neurotrophic factor NPY in neonates and induces neuroproliferation in neonatal and ...
Cuihong Jia, Colleen Cosgrove Hegg
doaj   +1 more source

Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway [PDF]

, 2023
Yuanshui Wu, Xiaoli Huang, Le Yang, Yuanjie Liu   +3 more
openalex   +1 more source

Roles of Purinergic Receptor P2Y, G Protein–Coupled 12 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Arteriosclerosis, Thrombosis and Vascular Biology, 2012
Objective—The aim of the study was to evaluate the role of purinergic receptor P2Y, G protein–coupled 12 (P2Y12), an ADP receptor, in the development of atherosclerotic lesions.
Ding Li, Yanhua Wang, Lin Zhang, Xinping Luo, Jian Li, Xue-jin Chen, Haixia Niu, Kemin Wang, Yueping Sun, Xuefeng Wang, Yan Yan, W. Chai, T. Gartner, Junling Liu   +13 more
semanticscholar   +1 more source

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera, Jason L. Rengo, Grant W. Hennig, Thomas J. Heppner, Alexandria M. Hepp, Maria Sancho, Saul Huerta de la Cruz, Mark T. Nelson, Nicholas R. Klug   +8 more
wiley   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Nerve‐evoked purinergic signalling suppresses action potentials, Ca²⁺ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle [PDF]

, 2009
Thomas J. Heppner, Matthias Werner, Bernhard Nausch, Catherine Vial, Richard J. Evans, Mark T. Nelson   +5 more
openalex   +1 more source

Targeting ecto‐5′‐nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats

The Journal of Physiology, EarlyView.
Abstract figure legend CD73 promotes carotid body hyperactivity in chronically hypoxic animals. Exposure to chronic hypoxia (CH) (FiO2 of 12% for 10 days) increases the proportion of CD73+TH+ cells in the carotid body and induces basal chemoafferent hyperactivity.
Demitris Nathanael, Andrew M. Coney, Dhaifallah Alotaibi, Prem Kumar, Andrew P. Holmes   +4 more
wiley   +1 more source