Results 111 to 120 of about 36,112 (247)

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

New paradigms in purinergic receptor ligand discovery. [PDF]

Neuropharmacology, 2023
Jacobson KA, Pradhan B, Wen Z, Pramanik A.   +3 more
europepmc   +1 more source

Biochemistry of P2y-purinergic receptors.

, 1990
T. Kendall Harden
openalex   +1 more source

Glioblastoma Tumor Microenvironment and Purinergic Signaling: Implications for Novel Therapies

Pharmaceuticals
Glial-origin brain tumors, particularly glioblastomas (GBMs), are known for their devastating prognosis and are characterized by rapid progression and fatal outcomes.
Martina Bedeschi, Elena Cavassi, Antonino Romeo, Anna Tesei   +3 more
doaj   +1 more source

The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis

, 2018
Hyunsoo Kim, Tetsuhiro Kajikawa, Matthew C. Walsh, Noriko Takegahara, Yun Hee Jeong, George Hajishengallis, Yongwon Choi   +6 more
openalex   +2 more sources

Roles of microglial purinergic receptors in inflammatory conditions of the brain

, 2010
Hyun B. Choi
openalex   +1 more source

Corrigendum to "New paradigms in purinergic receptor ligand discovery" [Neuropharmacology 230 (2023) 109503]. [PDF]

Neuropharmacology, 2023
Jacobson KA, Pradhan B, Wen Z, Pramanik A.   +3 more
europepmc   +1 more source

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling [PDF]

, 2019
Fatema Mousawi, Hongsen Peng, Jing Li, Sreenivasan Ponnambalam, Sébastien Roger, Hucheng Zhao, Xuebin Yang, Lin‐Hua Jiang   +7 more
openalex   +1 more source