Results 121 to 130 of about 2,325,321 (255)

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Comprehensive Genome‐Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases

Brain and Behavior, Volume 15, Issue 11, November 2025.
GI and ND GWAS and blood eQTL data were analyzed using LDSC, HDL, LAVA, GPA, PLACO, FUMA, MAGMA, SMR, HEIDI, and two‐sample MR to assess genetic correlations, pleiotropy, functional annotation, shared gene expression, and causal relationships. ABSTRACT Background This study investigates the shared genetic basis between gastrointestinal (GI) diseases ...
Yan Jiang, Yuxiang Zhang, Lei Ma, Chao Li   +3 more
wiley   +1 more source

Glioblastoma Tumor Microenvironment and Purinergic Signaling: Implications for Novel Therapies

Pharmaceuticals
Glial-origin brain tumors, particularly glioblastomas (GBMs), are known for their devastating prognosis and are characterized by rapid progression and fatal outcomes.
Martina Bedeschi, Elena Cavassi, Antonino Romeo, Anna Tesei   +3 more
doaj   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Prevalence and Prognostic Impact of Coronary Chronic Total Occlusions in Patients With Cardiogenic Shock

Catheterization and Cardiovascular Interventions, Volume 106, Issue 5, Page 2805-2815, November 1, 2025.
ABSTRACT Background Mortality in patients with cardiogenic shock (CS) remains high despite advanced treatment strategies in CS patients, underlining the need for the identification of predictors of prognosis in CS patients. Therefore, the present study investigates the prognostic impact of coronary chronic total occlusions (CTO) in patients with CS ...
Michael Behnes, Moritz Schmidberger, Giuseppe Vadalà, Alice Moroni, Juan‐Luis Guiterrez‐Chico, Stylianos Pyxaras, Alexander Bufe, Florian Krötz, Kambis Mashayekhi, Mohamed Ayoub, Jonas Rusnak, Mohammad Abumayyaleh, Jonas Dudda, Kathrin Weidner, Ibrahim Akin, Tobias Schupp   +15 more
wiley   +1 more source

New paradigms in purinergic receptor ligand discovery. [PDF]

Neuropharmacology, 2023
Jacobson KA, Pradhan B, Wen Z, Pramanik A.   +3 more
europepmc   +1 more source

Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation

, 2023
Seyed Hossein Kiaie, Zahra Hatami, Mohammad Sadegh Nasr, Pouya Pazooki, Salar Hemmati, Behzad Baradaran, Hadi Valizadeh   +6 more
openalex   +2 more sources

Effect and Mechanisms of Yiqi Jianpi Xiaoyu Prescription on Kidney Fibrosis on the Basis of Metabolomics and Experimental Validation

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Our results demonstrate that YQJPXY alleviates fibrosis by regulating key metabolites, including adenosine, adenine, and inosine, and activates autophagy through the A2BR/cAMP/AMPK pathway. ABSTRACT The Yiqi Jianpi Xiaoyu prescription (YQJPXY) exhibits ameliorative effects on kidney fibrosis, but the underlying mechanism related to metabolism remains ...
Keda Lu, Liqing Ye, Wenze Jiang, Tianyang Cheng, Hong Xia, Peipei Zhang, Bingbing Zhang   +6 more
wiley   +1 more source

Corrigendum to "New paradigms in purinergic receptor ligand discovery" [Neuropharmacology 230 (2023) 109503]. [PDF]

Neuropharmacology, 2023
Jacobson KA, Pradhan B, Wen Z, Pramanik A.   +3 more
europepmc   +1 more source

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

Glia, Volume 73, Issue 11, Page 2154-2166, November 2025.
Main Points Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols.
Xabier Cuesta‐Puente, Marco Gonzalez‐Dominguez, Marta Pereira‐Iglesias, Nerea Perez‐Arriazu, Patricia Villegas‐Zafra, Paula Ramos‐Gonzalez, Fabio Cavaliere, Nora Bengoa‐Vergniory, Amanda Sierra   +8 more
wiley   +1 more source