Results 141 to 150 of about 2,325,321 (255)

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Purinergic receptor: a crucial regulator of adipose tissue functions. [PDF]

Purinergic Signal, 2023
Wang D, Zhou J.
europepmc   +1 more source

Epithelial Wounds Induce Differential Phosphorylation Changes in Response to Purinergic and EGF Receptor Activation [PDF]

, 2013
Amanuel Kehasse, Celeste B. Rich, Albert Lee, Mark E. McComb, Catherine E. Costello, Vickery Trinkaus‐Randall   +5 more
openalex   +1 more source

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, Volume 182, Issue 21, Page 5378-5390, November 2025.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source

Dataset related to the article "Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation"

, 2023
Donato Moschetta, Enrico Di Maria, Vincenza Valerio, Ilaria Massaiu, Michele Bozzi, Paola Songia, Yuri D’Alessandra, Veronika A. Myasoedova, Paolo Poggio   +8 more
openalex   +1 more source

Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Both pharmacological blockade and genetic knockdown of astrocytic connexin43 channels in the preBötzinger complex induce a high‐frequency breathing pattern, thereby enhancing respiratory motor output. This effect is mediated by astrocytic activation and subsequent ATP release, which activates P2Y1 receptors on somatostatin‐expressing preBötzinger ...
Xue Zhao, Luo Shi, Yongqiang Chen, Hongxiao Yu, Xiaoyi Wang, Xinyi Jing, Tianjiao Deng, Ke Zhao, Xiang Zhang, Yixian Liu, Fang Yuan, Sheng Wang   +11 more
wiley   +1 more source

Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells

Molecular Pharmacology, 2017
Wayne Stallaert, E. T. van der Westhuizen, Anne-Marie Schönegge, Bianca Plouffe, M. Hogue, V. Lukashova, A. Inoue, S. Ishida, J. Aoki, C. Le Gouill, M. Bouvier   +10 more
semanticscholar   +1 more source

Synaptopathy in the TDP‐43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis

European Journal of Neuroscience, Volume 62, Issue 10, November 2025.
ABSTRACT Sporadic cases of amyotrophic lateral sclerosis (sALS) represent the most common form of motor neuron disease. sALS is characterised by pathological cytoplasmic inclusions of TDP‐43, so‐called reactive astrocyte pathology and motor neuron degeneration.
Ani Ayvazian‐Hancock, Emma Butler, Claire F. Meehan, Gareth B. Miles, Matthew J. Broadhead   +4 more
wiley   +1 more source

Altered purinergic receptor expression in the frontal cortex in schizophrenia. [PDF]

Schizophrenia (Heidelb), 2022
Alnafisah R, Lundh A, Asah SM, Hoeflinger J, Wolfinger A, Hamoud AR, McCullumsmith RE, O'Donovan SM.   +7 more
europepmc   +1 more source

Characterization of purinergic receptor expression in ARPKD cystic epithelia

Purinergic Signalling Purinergic Signalling, 2018
O. Palygin, D. Ilatovskaya, V. Levchenko, C. Klemens, Lashodya V. Dissanayake, A. Williams, T. Pavlov, A. Staruschenko   +7 more
semanticscholar   +1 more source