Results 11 to 20 of about 2,325,321 (255)
Frontiers in Immunology, 2021 Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases.
Xu Wang +8 more
doaj +2 more sources
Science Translational Medicine, 2022 Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking.
Ingmar Mederacke +21 more
openalex +3 more sources
Purine and purinergic receptors in health and disease
MedComm, 2023 Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai +6 more
doaj +2 more sources
P2 purinergic receptor dysregulation in urologic disease. [PDF]
Purinergic Signal, 2022 P2 purinergic receptors are involved in the normal function of the kidney, bladder, and prostate via signaling that occurs in response to extracellular nucleotides.
Maynard JP, Sfanos KS.
europepmc +2 more sources
Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells [PDF]
International Journal of Molecular Sciences, 2018 The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount ...
Patrick Frank Ottensmeyer +3 more
openalex +2 more sources
The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis
BMB Reports, 2018 Purinergic receptor signaling is increasingly recognized as an important regulator of inflammation. The P2X family purinergic receptors P2X5 and P2X7 have both been implicated in bone biology, and it has been suggested recently that P2X5 may be a ...
Hyunsoo Kim +6 more
openalex +3 more sources
Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7 [PDF]
Mucosal Immunology, 2016 The intestinal environment harbors a large number of activated T cells, which are potentially inflammatory. To prevent inflammatory responses, intestinal T cells are controlled by various tolerogenic mechanisms, including T-cell apoptosis.
Seika Hashimoto‐Hill +3 more
openalex +2 more sources
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile
Purinergic Signalling Purinergic Signalling, 2021 Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype.
J. Merz +20 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2020 Neuroinflammation is considered a key pathological process in neurodegenerative diseases of aging, including Alzheimer’s disease (AD). Many studies have defined phenotypes of reactive microglia, the brain-resident macrophages, with different antigenic ...
D. Walker +7 more
semanticscholar +1 more source
Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
Frontiers in Pharmacology, 2021 The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso +8 more
doaj +1 more source