Results 11 to 20 of about 2,316,796 (350)

P2X4: A fast and sensitive purinergic receptor

Biomedical Journal, 2017
Extracellular nucleotides have been recognized as important mediators of activation, triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 receptors comprise P2X ionotropic receptors and G protein-coupled P2Y receptors.
J. Suurväli, P. Boudinot, J. Kanellopoulos, S. Rüütel Boudinot   +3 more
semanticscholar   +6 more sources

Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile

Purinergic Signalling Purinergic Signalling, 2021
Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype.
J. Merz, A. Nettesheim, S. von Garlen, P. Albrecht, B. S. Saller, J. Engelmann, L. Hertle, I. Schäfer, D. Dimanski, S. König, L. Karnbrock, K. Bulatova, A. Peikert, N. Hoppe, I. Hilgendorf, C. von zur Mühlen, D. Wolf, O. Gross, C. Bode, A. Zirlik, P. Stachon   +20 more
semanticscholar   +1 more source

Purinergic Receptors in Ocular Inflammation [PDF]

Mediators of Inflammation, 2014
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ.
Ana Guzman-Aranguez, Xavier Gasull, Yolanda Diebold, Jesús Pintor   +3 more
openaire   +5 more sources

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains

International Journal of Molecular Sciences, 2020
Neuroinflammation is considered a key pathological process in neurodegenerative diseases of aging, including Alzheimer’s disease (AD). Many studies have defined phenotypes of reactive microglia, the brain-resident macrophages, with different antigenic ...
D. Walker, Tiffany M. Tang, Anarmaa Mendsaikhan, I. Tooyama, G. Serrano, L. Sue, T. Beach, L. Lue   +7 more
semanticscholar   +1 more source

Painful Purinergic Receptors [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2008
Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and ...
Diana L. Donnelly-Roberts, Char-Chang Shieh, Michael F. Jarvis, Prisca Honore, Steve McGaraughty   +4 more
openaire   +2 more sources

Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

Frontiers in Pharmacology, 2021
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso, Vanni Caruso, Mariachiara Zuccarini, Mariachiara Zuccarini, Patrizia Di Iorio, Patrizia Di Iorio, Ishaq Muhammad, Maurizio Ronci, Maurizio Ronci   +8 more
doaj   +1 more source

The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes

Science Signaling, 2020
Relocalization of P2Y11 purinergic receptors enables the polarization needed for T cell migration. Polarized by purinergic signaling Migration enables T cells to carry out many of their functions. Ledderose et al. found that T cell migration requires the
Carola Ledderose, Sophie Bromberger, Christian J. Slubowski, K. Sueyoshi, Dilan Aytan, Yong Shen, W. Junger   +6 more
semanticscholar   +1 more source

Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia

Frontiers in Physiology, 2023
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors.
Byeong J. Chun, Surya P. Aryal, Peter Varughese, Bin Sun, Joshua A. Bruno, Chris I. Richards, Adam D. Bachstetter, Peter M. Kekenes-Huskey   +7 more
doaj   +1 more source

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders

Brain Sciences, 2023
Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec, Anna Wilkaniec, Marta Matuszewska, Ewelina Pałasz, Magdalena Cieślik, Agata Adamczyk   +5 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source