Results 11 to 20 of about 2,359,528 (327)

Targeting Purinergic Receptor P2RX1 Modulates Intestinal Microbiota and Alleviates Inflammation in Colitis

Frontiers in Immunology, 2021
Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases.
Xu Wang, Xiao Yuan, Yuting Su, Jing Hu, Qian Ji, Shengqiao Fu, Rongkun Li, Lipeng Hu, C. Dai   +8 more
semanticscholar   +3 more sources

Purine and purinergic receptors in health and disease

MedComm, 2023
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shi-yu Tang, Jianyuan Tang, N. Chen   +6 more
semanticscholar   +2 more sources

The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection. [PDF]

Front Immunol, 2023
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood.
Lécuyer D, Nardacci R, Tannous D, Gutierrez-Mateyron E, Deva Nathan A, Subra F, Di Primio C, Quaranta P, Petit V, Richetta C, Mostefa-Kara A, Del Nonno F, Falasca L, Marlin R, Maisonnasse P, Delahousse J, Pascaud J, Deprez E, Naigeon M, Chaput N, Paci A, Saada V, Ghez D, Mariette X, Costa M, Pistello M, Allouch A, Delelis O, Piacentini M, Le Grand R, Perfettini JL.   +30 more
europepmc   +3 more sources

Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling. [PDF]

Front Immunol, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Espinosa G, Conejeros I, Rojas-Barón L, Hermosilla CR, Taubert A.   +4 more
europepmc   +2 more sources

Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy. [PDF]

Front Neurosci
Epilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy’s pathophysiology.
Espinosa N, Martín-Suárez S, Lara-Vasquez A, Montero T, Muro-García T, Fernandez G, Encinas-Pérez JM, Fuentealba P.   +7 more
europepmc   +2 more sources

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function [PDF]

, 2016
The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood ...
Acuña, Matias, Aprile García, Fernando, Arzt, Eduardo Simon, Deussing, Jan M., Gerez, Juan Atilio, Hoijman, Esteban, Holsboer, Florian, Liberman, Ana Clara, Metzger, Michael W., Mitkovski, Mišo, Paez Pereda, Marcelo, Panhuysen, Markus, Refojo, Damian, Senin, Sergio Ariel, Stadler, Herbert, Stühmer, Walter   +15 more
core   +16 more sources

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis

Frontiers in Immunology, 2021
Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang   +7 more
doaj   +1 more source

Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile

Purinergic Signalling Purinergic Signalling, 2021
Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype.
J. Merz, A. Nettesheim, S. von Garlen, P. Albrecht, B. S. Saller, J. Engelmann, L. Hertle, I. Schäfer, D. Dimanski, S. König, L. Karnbrock, K. Bulatova, A. Peikert, N. Hoppe, I. Hilgendorf, C. von zur Mühlen, D. Wolf, O. Gross, C. Bode, A. Zirlik, P. Stachon   +20 more
semanticscholar   +1 more source

Painful Purinergic Receptors [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2008
Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and ...
Diana, Donnelly-Roberts, Steve, McGaraughty, Char-Chang, Shieh, Prisca, Honore, Michael F, Jarvis   +4 more
openaire   +2 more sources