Results 11 to 20 of about 36,112 (247)

Painful Purinergic Receptors [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2008
Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and ...
Diana, Donnelly-Roberts, Steve, McGaraughty, Char-Chang, Shieh, Prisca, Honore, Michael F, Jarvis   +4 more
openaire   +2 more sources

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Journal of Pharmaceutical Analysis, 2023
Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou   +8 more
doaj   +1 more source

Targeting Purinergic Receptor P2RX1 Modulates Intestinal Microbiota and Alleviates Inflammation in Colitis

Frontiers in Immunology, 2021
Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases.
Xu Wang, Xiao Yuan, Yuting Su, Jing Hu, Qian Ji, Shengqiao Fu, Rongkun Li, Lipeng Hu, Chunhua Dai   +8 more
doaj   +1 more source

Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

Frontiers in Pharmacology, 2021
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso, Vanni Caruso, Mariachiara Zuccarini, Mariachiara Zuccarini, Patrizia Di Iorio, Patrizia Di Iorio, Ishaq Muhammad, Maurizio Ronci, Maurizio Ronci   +8 more
doaj   +1 more source

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders

Brain Sciences, 2023
Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec, Anna Wilkaniec, Marta Matuszewska, Ewelina Pałasz, Magdalena Cieślik, Agata Adamczyk   +5 more
doaj   +1 more source

Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia

Frontiers in Physiology, 2023
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors.
Byeong J. Chun, Surya P. Aryal, Peter Varughese, Bin Sun, Joshua A. Bruno, Chris I. Richards, Adam D. Bachstetter, Peter M. Kekenes-Huskey   +7 more
doaj   +1 more source

Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion

Viruses, 2020
Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1
Tracey L. Freeman, Talia H. Swartz
doaj   +1 more source

Purinergic signaling in infection and autoimmune disease

Biomedical Journal, 2016
Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites.
Luiz Eduardo Baggio Savio, Robson Coutinho-Silva   +1 more
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology.
Kazuaki Yoshioka, Hiroyasu Nakata
doaj   +1 more source

Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?

Frontiers in Allergy, 2021
Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently,
Rebecca J. Thompson, Ian Sayers, Katja Kuokkanen, Ian P. Hall   +3 more
doaj   +1 more source