Results 31 to 40 of about 2,325,321 (255)
Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy
Frontiers in Pharmacology, 2018 Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system.
Ágatha Oliveira-Giacomelli +7 more
doaj +1 more source
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
Nature, 2018 Extracellular ATP (eATP) is an ancient ‘danger signal’ used by eukaryotes to detect cellular damage1. In mice and humans, the release of eATP during inflammation or injury stimulates both innate immune activation and chronic pain through the purinergic ...
Henrique Borges da Silva +16 more
semanticscholar +1 more source
Folia Neuropathologica, 2022 Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec +2 more
doaj +1 more source
Ethanol upregulates the P2X7 purinergic receptor in human macrophages
Fundamental & Clinical Pharmacology, 2018 Alcohol consumption is considered to be the third leading cause of death in the United States. In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain‐like receptor pyrin domain ...
Brendan Le Daré +7 more
semanticscholar +1 more source
Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia
Journal of Neuroinflammation, 2009 Microglia are implicated in multiple neurodegenerative disorders, many of which display sexual dimorphisms and have symptom onsets at different ages. P2 purinergic receptors are critical for regulating various microglial functions, but little is known ...
Nikodemova Maria +2 more
doaj +1 more source
Purinergic signaling in schistosomal infection
Biomedical Journal, 2016 Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life ...
Claudia Lucia Martins Silva
doaj +1 more source
The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2
Frontiers in Immunology, 2022 A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions.
Davide Ferrari +4 more
doaj +1 more source
Scientific Reports, 2017 Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength.
Hyunsook Kim +6 more
semanticscholar +1 more source
mBio, 2017 An exacerbated immune response is one of the main causes of influenza-induced lung damage during infection. The molecular mechanisms regulating the fate of the initial immune response to infection, either as a protective response or as detrimental ...
V. Leyva-Grado +6 more
semanticscholar +1 more source
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
Journal of Experimental Medicine, 2022 Microglia modulate cerebral blood flow (CBF) through complex purinergic actions, which are mediated by dynamic, P2Y12 receptor-driven interactions with the vasculature. Microglial actions are partially independent of nitric oxide.
E. Császár +25 more
semanticscholar +1 more source