Results 121 to 130 of about 842,442 (245)
Purinergic Signaling in Neuroinflammation
, 2023 It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided
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Biology Open, 2017 Disruption of cellular plasma membranes is a common event in many animal tissues, and the membranes are usually rapidly resealed. Moreover, repeated membrane disruptions within a single cell reseal faster than the initial wound in a protein kinase A (PKA)
Tatsuru Togo
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Unlocking the potential of purinergic signaling in transplantation [PDF]
, 2016 Purinergic signaling has been recognized as playing an important role in inflammation, angiogenesis, malignancy, diabetes and neural transmission.
Robson, Simon C. +9 more
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Mechanisms of astrocytic and microglial purinergic signaling in homeostatic regulation and implications for neurological disease [PDF]
Exploration of NeurosciencePurinergic signaling, mediated by ATP and adenosine receptors, plays a crucial role in cellular communication and homeostasis within the central nervous system (CNS), particularly by regulating synaptic activity, glial cell functions, and neuroplasticity.
Moawiah M Naffaa
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CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
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International Endodontic Journal, EarlyView.ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne +4 more
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Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]
, 2015 The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte +2 more
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Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling
Oral Diseases, EarlyView.ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung +4 more
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Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
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, 2020 © 2016, Springer Science+Business Media Dordrecht.Extracellular ATP is suspected to contribute to migraine pain but regulatory mechanisms controlling pro-nociceptive purinergic mechanisms in the meninges remain unknown.
Yegutkin G. +8 more
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