Results 131 to 140 of about 932,452 (224)
Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity
Glia, Volume 74, Issue 12, December 2026.The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert +2 more
wiley +1 more source
, 2014 This thesis concerns purinergic signaling in renal epithelial cells of normal and polycystic kidneys. The first section discusses first principles of “purinergic signaling ” as they relate to the nephron and the urinary bladder.
J. Michael Wyss +5 more
core
The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 10, Page 977-992, December 2026.Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario +3 more
wiley +1 more source
Purinergic Signaling in Stemness: The Potential Role of CD38 in Leukemia Development
reservedPurinergic signaling is a critical pathway in cell-to-cell communication, influencing various cellular processes such as differentiation and self-renewal.
NASIRI, AYSA
core
Sodium Ions Affect GPR17 Conformational States and Functionality
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 12, Page 1949-1964, December 2026.ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo +6 more
wiley +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Wei Jiang +4 more
wiley +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, Volume 13, Issue 61, 3 November 2026.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha +9 more
wiley +1 more source
Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies
CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han +7 more
wiley +1 more source