Results 131 to 140 of about 44,500 (210)
Connexin26 and 43 play a role in regulating pro-inflammatory events in the epidermis [PDF]
, 2019 Bartholomew, Christopher +4 more
core +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling +17 more
wiley +1 more source
Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, Volume 78, Issue 4, Page 896-903, April 2026.Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 4, April 2026.The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong +5 more
wiley +1 more source
Red Blood Cell Membrane Mechanics Using Discrete Exterior Calculus (DEC) and Optimization
International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 4, April 2026.We present a novel DEC approach for calculating RBC shapes applicable to other cell types and membrane problems. We derive an energy minimization equation that can be solved semi‐implicitly, and a Lie derivative method to control node spacing. This novel work should aid computational modeling in many biological situations.
Keith C. Afas, Daniel Goldman
wiley +1 more source
Pathological Roles of Astrocytes in Traumatic Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu +7 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao +8 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu +11 more
wiley +1 more source
Protective Effect of Silymarin Against Paclitaxel‐Induced Cardiotoxicity
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Paclitaxel, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis leading to cardiotoxicity. In this study, silymarin supplementation significantly reduced oxidative stress markers, downregulated inflammatory cytokines (IL‐1β, TNF‐α, NF‐κB), and restored the balance between pro‐ and anti‐apoptotic proteins in rat heart ...
Tuğçe Tutar +4 more
wiley +1 more source
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source