Results 191 to 200 of about 4,625,876 (321)

Signal transduction mechanism of P2-purinergic receptors in thyroid cells.

, 1991
Fumikazu Okajima, Hideaki Tomura, Kōichi Sato, Martina Nazarea, Kimie Sho, Yoichi Kondo   +5 more
openalex   +1 more source

Purinergic signalling in the immune system. A brief update [PDF]

, 2007
Francesco Di Virgilio
openalex   +1 more source

Activation of Adenosine Phosphate Signaling Promotes Antitumor Immunity in Tumor Microenvironment and Facilitate Immunotherapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
A comprehensive analysis of the purinergic signaling mediated by P2 receptors (P2Rs) was conducted at both bulk, single‐cell, and spatial transcriptomic levels, evaluating the prognostic and predictive value of the adenosine signaling pathway in cancer immunotherapy.
Yantao Xu, Ying Wang, Zixi Jiang, Yi He, Guowei Zhou, Benliang Wei, Jiachen Liu, Xiang Chen   +7 more
wiley   +1 more source

Extracellular purines in lung endothelial permeability and pulmonary diseases

Frontiers in Physiology
The purinergic signaling system is an evolutionarily conserved and critical regulatory circuit that maintains homeostatic balance across various organ systems and cell types by providing compensatory responses to diverse pathologies.
Evgenia Gerasimovskaya, Rahul S. Patil, Adrian Davies, McKenzie E. Maloney, McKenzie E. Maloney, Liselle Simon, Basmah Mohamed, Mary Cherian-Shaw, Alexander D. Verin, Alexander D. Verin   +9 more
doaj   +1 more source

Inositol Triphosphate-Mediated Ca²⁺Signals Direct Purinergic P2Y Receptor Regulation of Neuronal Ion Channels [PDF]

, 2007
Oleg Zaika, Gleb P. Tolstykh, David B. Jaffe, Mark S. Shapiro   +3 more
openalex   +1 more source

Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF‐κB, Bcl‐2, and Caspase‐3 in LPS‐Induced Endotoxemia

Environmental Toxicology, Volume 40, Issue 6, Page 924-934, June 2025.
ABSTRACT Sepsis remains the leading cause of multiple‐organ injury due to endotoxemia. Astaxanthin (ASTA), widely used in marine aquaculture, has an extraordinary potential for antioxidant and anti‐inflammatory activity. Purinergic receptor (e.g., P2X7R) activation is a powerful signaling in the modulation of inflammation.
Seckin Ozkanlar, Yunusemre Ozkanlar, Adem Kara, Elif Dalkilinc   +3 more
wiley   +1 more source

SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling

Acta Physiologica, Volume 241, Issue 6, June 2025.
ABSTRACT Introduction The receptor SorCS2 is involved in the trafficking of membrane receptors and transporters. It has been implicated in brain disorders and has previously been reported to be indispensable for ionotropic glutamatergic neurotransmission in the hippocampus.
Christian Staehr, Hande Login, Elizaveta V. Melnikova, Magdalena Bakun, Ewelina Ziemlinska, Lilian Kisiswa, Simin Berenji Ardestani, Stella Solveig Nolte, Hans Christian Beck, Line Mathilde Brostrup Hansen, Dmitry Postnov, Alexei Verkhratsky, Anna R. Malik, Anders Nykjaer, Vladimir V. Matchkov   +14 more
wiley   +1 more source

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

Neural Regeneration Research
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss, Christine Heuer, Marina Herwerth   +2 more
doaj   +1 more source

Blockade of P2X7 receptors preserves blood retinal barrier integrity by modulating the plasmalemma vesicle‐associated protein: Implications for diabetic retinopathy

British Journal of Pharmacology, Volume 182, Issue 12, Page 2603-2620, June 2025.
Background and Purpose Plasmalemma vesicle‐associated protein (PLVAP) regulates transcytosis in vascular endothelial cells. PLVAP expression is increased in pathological conditions, such as diabetic retinopathy. P2X7 receptor antagonists have been shown to preserve blood‐retinal barrier (BRB) integrity.
Chiara Bianca Maria Platania, Francesca Lazzara, Kenneth Mitton, Naomi Haque, Wendelin Dailey, Federica Conti, Erika Giuffrida, Filippo Drago, Anca Hermenean, Cornel Balta, Hildegard Herman, Alina Ciceu, Maria Consiglia Trotta, Michele D'Amico, Giuseppe Nicosia, Settimio Rossi, Claudio Bucolo   +16 more
wiley   +1 more source

Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review

Purinergic Signalling Purinergic Signalling, 2021
A. Cardoso, Mauro N. O. Silvério, S. F. V. de Oliveira Maciel   +2 more
semanticscholar   +1 more source