Results 61 to 70 of about 22,737 (199)

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Journal of Pharmaceutical Analysis, 2023
Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou   +8 more
doaj  

Age- and Experience-Related Plasticity of ATP-Mediated Signaling in the Neocortex

Frontiers in Cellular Neuroscience, 2019
There is growing recognition of the important role of interaction between neurons and glial cells for brain longevity. The extracellular ATP have been shown to bring significant contribution into bi-directional glia-neuron communications, in particular ...
Ulyana Lalo, Alexander Bogdanov, Yuriy Pankratov   +2 more
doaj   +1 more source

Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor

The FEBS Journal, EarlyView.
The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz, Marius Landau, Andrei N. Lupas, Joachim Erdmann Schultz   +3 more
wiley   +1 more source

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, EarlyView.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, EarlyView.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source

Mitogenic Signaling by ATP/P2Y Purinergic Receptors in Astrocytes: Involvement of a Calcium-Independent Protein Kinase C, Extracellular Signal-Regulated Protein Kinase Pathway Distinct from the Phosphatidylinositol-Specific Phospholipase C/Calcium Pathway [PDF]

, 1999
Joseph T. Neary, Yuan Kang, Yurong Bu, Esther J. Yu, Katherine Akong, Christopher M. Peters   +5 more
openalex   +1 more source

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats

The Journal of Physiology, EarlyView.
Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq, Laura Anselmi, Salvatore L. Stella Jr, Steven W. Copp, Victor Ruiz‐Velasco, Marc P. Kaufman   +5 more
wiley   +1 more source