Results 61 to 70 of about 4,625,876 (321)
Purinergic signaling in the ovary [PDF]
Molecular Reproduction and Development, 2015 SUMMARYAdenosine triphosphate (ATP) is released from the cell by multiple mechanisms. The extracellular form of this purine is processed by ectonucleotidases, resulting in a variety of dephosphorylated metabolites that can bind to specific receptors found in the membrane of target cells; such purinergic signaling is important as an autocrine‐paracrine ...
A. S. Martínez-Ramírez +1 more
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The role of purinergic signaling in microglial responses
Stress and Brain, 2021 Microglia, the primary immune cells in the central nervous system (CNS), are key to the maintenance of homeostasis in the brain parenchyma. In the intact brain, microglia continuously survey the microenvironment with ramified processes.
Yaling Hu, Zhihua Gao
doaj +1 more source
Purinergic signalling and immune cells [PDF]
Purinergic Signalling, 2014 This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all
Burnstock, G, Boeynaems, JM
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Purinergic signaling in kidney disease [PDF]
Kidney International, 2017 Nucleotides are key subunits for nucleic acids and provide energy for intracellular metabolism. They can also be released from cells to act physiologically as extracellular messengers or pathologically as danger signals. Extracellular nucleotides stimulate membrane receptors in the P2 and P1 family. P2X are ATP-activated cation channels; P2Y and P1 are
Robert J. Unwin +4 more
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Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]
, 2017 Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi +12 more
core +3 more sources
Highlights in Purinergic Signalling [PDF]
Purinergic Signalling, 2009 It has become increasingly clear that receptors and ion channels in the plasma membrane do not exist and function in isolation, but instead form complexes with other proteins and this can modify their expression and activity. In this study, the authors determined which proteins complex with the P2X2 receptor and characterised the influence of one ...
openaire +4 more sources
The involvement of purinergic signalling in obesity [PDF]
Purinergic Signalling, 2018 Obesity is a growing worldwide health problem, with an alarming increasing prevalence in developed countries, caused by a dysregulation of energy balance. Currently, no wholly successful pharmacological treatments are available for obesity and related adverse consequences.
Geoffrey Burnstock, Daniela Gentile
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Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. [PDF]
, 2012 BACKGROUND: Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. METHODS: Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp ...
Blackman, Michael J +6 more
core +4 more sources
Purinergic Signaling during Inflammation [PDF]
New England Journal of Medicine, 2012 Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.
Michail V. Sitkovsky +2 more
openaire +5 more sources
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
core +3 more sources