Results 71 to 80 of about 4,625,876 (321)

Control of Gut Inflammation by Modulation of Purinergic Signaling

Frontiers in Immunology, 2020
Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often
M. Vuerich, S. Mukherjee, S. Robson, M. Longhi   +3 more
semanticscholar   +1 more source

Purinergic signalling in osteoblasts

Frontiers in Bioscience, 2012
The skeleton is maintained throughout life via the finely tuned actions of osteoblasts and osteoclasts, with disruption in this balance eventually leading to bone disease. The exact mechanisms balancing these actions are not fully known, although several regulatory systems are known to be involved.
Gartland, Alison, Orriss, Isabel R., Rumney, Robin M.H., Bond, Alistair P., Arnett, Timothy, Gallagher, James A.   +5 more
openaire   +4 more sources

Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]

, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C., Kelly, M. C., Kennedy-Lydon, T. M., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +4 more
core   +2 more sources

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm
The gliotransmitter adenosine 5'‐triphosphate (ATP) and its enzymatic degradation product adenosine play a major role in orchestrating in the hippocampus cognitive and affective functions via P2 purinoceptors (P2X, P2Y) and P1 adenosine receptors (A1 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
doaj   +1 more source

ENTPDase inhibitors: therapeutic potential in infectious, inflammatory, and neuroinflammatory diseases [PDF]

Exploration of Neuroscience
Ectonucleoside triphosphate diphosphohydrolases (ENTPDases), members of the cluster of differentiation 39 (CD39) family, are key regulators of purinergic signaling through the hydrolysis of tri and diphosphate nucleotides.
Isadora Cunha Ribeiro, Amanda Laviola de Andrade, Vitória de Almeida Rodrigues, Markson Suarez Lacôrte Lima, Juliana Lopes Rangel Fietto   +4 more
doaj   +1 more source

P2 Purinergic Signaling in the Distal Lung in Health and Disease

International Journal of Molecular Sciences, 2020
The distal lung provides an intricate structure for gas exchange in mammalian lungs. Efficient gas exchange depends on the functional integrity of lung alveoli.
E. Wirsching, M. Fauler, G. Fois, M. Frick   +3 more
semanticscholar   +1 more source

Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease

Annals of Neurology, EarlyView.
Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira, Mafalda Raposo, Emily D. Shaw, Louisa Liu, João Vasconcelos, Teresa Kay, Conceição Bettencourt, Maria Luiza Saraiva‐Pereira, Laura Bannach Jardim, Maria do Carmo Costa, Manuela Lima   +10 more
wiley   +1 more source

Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design

ChemMedChem, 2020
The purinergic signaling system includes membrane‐bound receptors for extracellular purines and pyrimidines, and enzymes/transporters that regulate receptor activation by endogenous agonists.
V. Salmaso, K. Jacobson
semanticscholar   +1 more source

Dissecting the Purinergic Signaling Puzzle

International Journal of Molecular Sciences, 2021
Purinergic signaling regulates a plethora of physiological processes and is an expanding research field [...]
Raquel Pérez-Sen, Esmerilda G. Delicado
openaire   +4 more sources