Results 81 to 90 of about 22,737 (199)

The Role of Peripheral N‐Methyl‐D‐Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review

European Journal of Pain, Volume 29, Issue 7, August 2025.
ABSTRACT Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Emerging evidence suggests that peripheral NMDA receptors contribute to pathological pain and potentially ...
Ryusuke Tanaka, Silvia Lo Vecchio, Giulia Erica Aliotta, Lars Arendt‐Nielsen   +3 more
wiley   +1 more source

Surveilling microglia dampens neuronal activity: operation of a purinergically mediated negative feedback mechanism

Signal Transduction and Targeted Therapy, 2021
Peter Illes, Alexei Verkhratsky, Yong Tang   +2 more
doaj   +1 more source

Potential therapeutic targets in the rapidly expanding field of purinergic signalling [PDF]

, 2002
Geoffrey Burnstock
openalex   +1 more source

The Aquaporin‐4 Expression and Localization in the Olfactory Epithelium Modulate the Odorant‐Evoked Responses and Olfactory‐Driven Behavior

Glia, Volume 73, Issue 8, Page 1642-1659, August 2025.
Main Points AQP4ex and OAP‐forming AQP4M23 are expressed in non‐neuronal cells of the olfactory epithelium. AQP4ex‐KO and OAP‐null mice show reduced cell density, including OSNs, and impaired odor responses and behavior, with AQP4ex emerging as key regulator.
Donatella Lobraico, Pasqua Abbrescia, Maria Grazia Fioriello, Barbara Barile, Claudia Palazzo, Onofrio Valente, Grazia Paola Nicchia, Michele Dibattista, Antonio Frigeri   +8 more
wiley   +1 more source

Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors [PDF]

, 2003
Santina Bruzzone, Svenja Kunerth, Elena Zocchi, Antonio De Flora, Andreas H. Guse   +4 more
openalex   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, Volume 73, Issue 8, Page 1673-1691, August 2025.
Main Points Astroglial CB1 mediate long‐term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amphetamine effects in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
ABSTRACT The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, whereas long‐term control of coronary flow also involves remodelling of the coronary microvasculature ...
Oana Sorop, J. van de Wouw, Daphne Merkus, Dirk J. Duncker   +3 more
wiley   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling [PDF]

, 2008
C. William Davis, Eduardo R. Lazarowski
openalex   +3 more sources

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source