Results 111 to 120 of about 7,662 (216)

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Burnstock oration - purinergic signalling in kidney transplantation. [PDF]

Purinergic Signal, 2022
Dwyer KM.
europepmc   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Beyond the surface: P2Y receptor downstream pathways, TLR crosstalk and therapeutic implications for infection and autoimmunity

Pharmacological Research
A successful immune response must effectively obtain pathogen clearance upon infection while preventing excessive collateral tissue damage. It is therefore essential to achieve a nuanced fine regulation of pro- and anti-inflammatory signals to ...
Lena Rueschpler, Sebastian Schloer
doaj   +1 more source

Colorectal Cancer and Purinergic Signalling: An Overview. [PDF]

Cancers (Basel), 2022
Roliano GG, Azambuja JH, Brunetto VT, Butterfield HE, Kalil AN, Braganhol E.   +5 more
europepmc   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Exploration of the link between gut microbiota and purinergic signalling. [PDF]

Purinergic Signal, 2023
Li M, Liu B, Li R, Yang P, Leng P, Huang Y.   +5 more
europepmc   +1 more source

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

, 2023
Bo Yang, Nengwei Yu
openalex   +1 more source

A Novel Catalytically Inactive Construct of Botulinum Neurotoxin A (BoNT/A) Directly Inhibits Visceral Sensory Signalling

Toxins
Botulinum neurotoxin A (BoNT/A) is a potent neurotoxin that silences cholinergic neurotransmission through the cleavage of the synaptic protein SNAP-25.
Hodan Ibrahim, Kevin Retailleau, Fraser Hornby, Jacquie Maignel, Matthew Beard, Donna Marie Daly   +5 more
doaj   +1 more source