Results 111 to 120 of about 4,625,657 (223)

Burnstock oration - purinergic signalling in kidney transplantation. [PDF]

Purinergic Signal, 2022
Dwyer KM.
europepmc   +1 more source

Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors [PDF]

, 2003
Santina Bruzzone, Svenja Kunerth, Elena Zocchi, Antonio De Flora, Andreas H. Guse   +4 more
openalex   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, Volume 73, Issue 8, Page 1673-1691, August 2025.
Main Points Astroglial CB1 mediate long‐term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amphetamine effects in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

Journal of Bone Oncology, 2021
Background: Osteosarcoma (OS) is the most common type of primary bone cancer affecting children and adolescents. OS has a high propensity to spread meaning the disease is often incurable and fatal.
Luke Tattersall, Karan M. Shah, Darren L. Lath, Archana Singh, Jennifer M. Down, Elena De Marchi, Alex Williamson, Francesco Di Virgilio, Dominique Heymann, Elena Adinolfi, William D. Fraser, Darrell Green, Michelle A. Lawson, Alison Gartland   +13 more
doaj  

Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
ABSTRACT The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, whereas long‐term control of coronary flow also involves remodelling of the coronary microvasculature ...
Oana Sorop, J. van de Wouw, Daphne Merkus, Dirk J. Duncker   +3 more
wiley   +1 more source

Role of purinoreceptors in the release of extracellular vesicles and consequences on immune response and cancer progression

Biomedical Journal
Cell-to-cell communication is a major process for accommodating cell functioning to changes in the environments and to preserve tissue and organism homeostasis.
Thomas Duret, Mohammed Elmallah, Jérôme Rollin, Philippe Gatault, Lin-Hua Jiang, Sébastien Roger   +5 more
doaj  

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling [PDF]

, 2008
C. William Davis, Eduardo R. Lazarowski
openalex   +3 more sources

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source