Results 211 to 220 of about 4,754,967 (333)

A Novel Catalytically Inactive Construct of Botulinum Neurotoxin A (BoNT/A) Directly Inhibits Visceral Sensory Signalling

Toxins
Botulinum neurotoxin A (BoNT/A) is a potent neurotoxin that silences cholinergic neurotransmission through the cleavage of the synaptic protein SNAP-25.
Hodan Ibrahim, Kevin Retailleau, Fraser Hornby, Jacquie Maignel, Matthew Beard, Donna Marie Daly   +5 more
doaj   +1 more source

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, Volume 182, Issue 13, Page 2950-2967, July 2025.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source

Characterization of an alternative splice variant of human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): A possible modulator of nucleotidase activity and purinergic signaling [PDF]

, 2006
Patrick A. Crawford, Keith J. Gaddie, Thomas M. Smith, Terence L. Kirley   +3 more
openalex   +1 more source

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling. [PDF]

Elife, 2022
Randzavola LO, Mortimer PM, Garside E, Dufficy ER, Schejtman A, Roumelioti G, Yu L, Pardo M, Spirohn K, Tolley C, Brandt C, Harcourt K, Nichols E, Nahorski M, Woods G, Williamson JC, Suresh S, Sowerby JM, Matsumoto M, Santos CXC, Kiar CS, Mukhopadhyay S, Rae WM, Dougan GJ, Grainger J, Lehner PJ, Calderwood MA, Choudhary J, Clare S, Speak A, Santilli G, Bateman A, Smith KGC, Magnani F, Thomas DC.   +34 more
europepmc   +1 more source

Terpene Hydroperoxides as Lipid Peroxidation Inducers: Biomimetic and HaCaT Cell Studies in Allergic Contact Dermatitis

Contact Dermatitis, Volume 93, Issue 1, Page 16-30, July 2025.
Fragrance terpene hydroperoxides from limonene, linalool, and geraniol induced the formation of lipid peroxidation products when incubated with PLPC liposomes or in vitro with HaCaT keratinocytes. Lipid peroxidation products included aldehydes, ketones, and hydroperoxides.
Aaron I. Moore, Ana S. P. Moreira, Tiago Conde, Tânia Melo, Pedro Domingues, Niamh M. O'Boyle, M. Rosário Domingues   +6 more
wiley   +1 more source

Participation of the Lys313-Ile333 Sequence of the Purinergic P2X4 Receptor in Agonist Binding and Transduction of Signals to the Channel Gate [PDF]

, 2006
Zonghe Yan, Zhaodong Liang, Tomáš Obšil, Stanko S. Stojilković   +3 more
openalex   +1 more source

Purinergic signalling in the urinary bladder - When function becomes dysfunction. [PDF]

Auton Neurosci, 2021
Fry CH, McCloskey KD.
europepmc   +1 more source

Connexin26 and 43 play a role in regulating pro-inflammatory events in the epidermis [PDF]

, 2019
Bartholomew, Christopher, García-Vega, Laura, Jan, Afnan, Martin, Patricia E., O'Shaughnessy, Erin M.   +4 more
core   +1 more source

It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus is a primary lymphoid organ for generating a diverse yet self‐tolerant T cell repertoire. Among the thymic stromal cells that create the thymic microenvironment, thymic epithelial cells (TECs) have received the most attention because of their distinctive functions in the repertoire selection of T cells. Other types of thymic stromal
Ryunosuke Muro, Takeshi Nitta
wiley   +1 more source

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma

Molecular Carcinogenesis, Volume 64, Issue 6, Page 1039-1056, June 2025.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Chengzhi Zhao, Yuhao Wang, Zhishen Jiang, Shengzhao Guo, Liru Hu, Jian Pan, Fan Dan   +6 more
wiley   +1 more source