Results 71 to 80 of about 7,462 (180)

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener   +2 more
wiley   +1 more source

Generalised Hodgkin–Huxley model captures human P2X and AMPA receptor currents

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A universal, biophysically interpretable mathematical model for human ionotropic receptors. The generalised Hodgkin–Huxley (gHH) model unifies the mathematical description of all major ligand‐gated ionotropic receptors (P2X1–7, AMPA) across diverse cell types, capturing activation, inactivation, desensitisation and recovery ...
Alireza Poshtkohi, Brian D. Gulbransen
wiley   +1 more source

Purinergic Signalling in the Cochlea. [PDF]

open access: yesInt J Mol Sci, 2022
Vlajkovic SM, Thorne PR.
europepmc   +1 more source

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera   +8 more
wiley   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

open access: yes
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil   +11 more
wiley   +1 more source

Targeting ecto‐5′‐nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend CD73 promotes carotid body hyperactivity in chronically hypoxic animals. Exposure to chronic hypoxia (CH) (FiO2 of 12% for 10 days) increases the proportion of CD73+TH+ cells in the carotid body and induces basal chemoafferent hyperactivity.
Demitris Nathanael   +4 more
wiley   +1 more source

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