Results 51 to 60 of about 6,124 (266)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Hierarchical Maneuver Decision Method Based on PG-Option for UAV Pursuit-Evasion Game

Drones, 2023
Aiming at the autonomous decision-making problem in an Unmanned aerial vehicle (UAV) pursuit-evasion game, this paper proposes a hierarchical maneuver decision method based on the PG-option.
Bo Li, Haohui Zhang, Pingkuan He, Geng Wang, Kaiqiang Yue, Evgeny Neretin   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Scalable Pursuit–Evasion Game for Multi-Fixed-Wing UAV Based on Dynamic Target Assignment and Hierarchical Reinforcement Learning

Drones
The unmanned aerial vehicle (UAV) pursuit–evasion game is the fundamental framework for promoting autonomous decision-making and collaborative control of multi-UAV systems.
Mulai Tan, Haocheng Sun, Dali Ding, Huan Zhou, Yongli Liu   +4 more
doaj   +1 more source

Models and Strategies for J2-Perturbed Orbital Pursuit–Evasion Games

Space: Science & Technology, 2023
This paper discusses the modeling and solving of orbital pursuit–evasion games (OPEGs) under J2 perturbation. The optimal long-range maneuver method under J2 perturbation is designed, and it is proved that the effect of eccentricity can be ignored when ...
Hongyu Han, Zhaohui Dang
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Pursuit-evasion games: a tractable framework for antijamming games in aerial attacks

EURASIP Journal on Wireless Communications and Networking, 2017
We solve a communication problem between a UAV and a set of receivers, in the presence of a jamming UAV, using differential game theory tools. We propose a new approach in which this kind of games can be approximated as pursuit-evasion games. The problem
Juan Parras, Santiago Zazo, Jorge del Val, Javier Zazo, Sergio Valcarcel Macua   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Optimal Intermittent Sensing for Pursuit–Evasion Games

IEEE Control Systems Letters, 2023
We consider a class of pursuit-evasion differential games in which the evader has continuous access to the pursuer's location, but not vice-versa. There is a remote sensor (e.g., a radar station) that can sense the evader's location upon a request from the pursuer and communicate that sensed location to the pursuer.
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source