Results 91 to 100 of about 12,669 (162)

Novel antagonists reveal the mechanism of PXR inhibition

Trends in Pharmacological Sciences
The pregnane X receptor (PXR) is a key regulator of metabolism, but the mechanisms underlying its antagonism remain unclear. Garcia-Maldonado et al. reported potentnew antagonists and their cocrystal structures, revealing molecular determinants of PXR antagonism and paving the way for developing antagonists as therapeutics and preventing undesirable ...
Pavek, Petr, Kamaraj, Rajamanikkam
openaire   +2 more sources

Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health

Cells
This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic metabolism in liver, emerges as a key regulator influencing intestinal ...
Jeff L. Staudinger, Avina Mahroke, Gauri Patel, Cole Dattel, Sahana Reddy   +4 more
doaj   +1 more source

Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways. [PDF]

Int J Biol Sci
Zhang Y, Lan H, Yu X, Zhuo L, Zhao B, Liu F, An L, Zhang F, Liu Z, Wang C.   +9 more
europepmc   +1 more source

Pregnane X receptor (PXR) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Bisphenol F and Steatotic Liver Disease: Resolving the PXR Paradox Through Stress Pathway Mechanisms. [PDF]

Biomedicines
AbdalHussin EA, Abd Hamid Z, Md Idris MH, Omar MH, Taib IS.   +4 more
europepmc   +1 more source

Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor. [PDF]

Front Immunol
Lin T, Chen Y, Liu L, Wu T, Qian Y, Jin B.   +5 more
europepmc   +1 more source

Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis. [PDF]

Front Pharmacol
Rao S, Mei Y, Shi L, Li H, Zhou M, Meng Z, Zhao Z, Li S, Sun W, Tian Q.   +9 more
europepmc   +1 more source

Bile acid signaling mediates gut microbiota regulation of host lipid metabolism. [PDF]

Front Microbiol
Liu M, He C, Lv X, Zheng W, Yin J, Li Y, Ma J.   +6 more
europepmc   +1 more source

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors. [PDF]

Nat Commun
Huber AD, Lin W, Jung YH, Poudel S, Yang G, Wu J, Carrigan AG, Pagala V, Wang W, Fu Y, Yuan ZF, Byrum SD, Yang K, Gee RRF, Arnold ED, Loughran AJ, Wang J, Pruett-Miller SM, Peng J, Chen T.   +19 more
europepmc   +1 more source

Malignant hypertension and pseudohyperaldosteronism associated with rifampicin therapy. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Szedleski A, Ilbert C, Goncette V, Vroonen L, Huart J.   +4 more
europepmc   +1 more source